Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction

J. B. Lee; C. W. Mun; H. H. Choi; J. C. Park; J. B. Choi; Jeong Koo Kim

doi:10.1007/978-3-540-68017-8_33

Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction

J. B. Lee, C. W. Mun, H. H. Choi, J. C. Park, J. B. Choi, Jeong Koo Kim

Department of Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

PLGA (75:25)/hydroxyapatite (HA) composite films were fabricated by solvent-casting method to investigate the effect of various hydroxyapatite content ratio to the PLGA for mechanical properties, cellular attachment and proliferation. Mechanical property of the composite film was characterized by tensile test. The ultimate tensile strength of 10 wt% HA content film was two-fold higher than control group. Surface of the film was characterized by contact angle measurement and scanning electron microscope (SEM). The PLGA/HA composites were more hydrophilic than control. Chondrocyte responses to the composite films were measured in vitro by cellular attachment and proliferation test. The attached and proliferated cells were significantly higher on PLGA/HA (10 wt%) composite film than control group (1.44 times higher in attachment test and 1.31 times higher for 6thday at culture in proliferation assaying, p<0.05).

Original language	English
Title of host publication	3rd Kuala Lumpur International Conference on Biomedical Engineering 2006
Editors	Fatimah Ibrahim, Noor Azuan Abu Osman, Juliana Usman, Nahrizul Adib Kadri
Publisher	Springer Verlag
Pages	130-133
Number of pages	4
ISBN (Electronic)	9783540680161
DOIs	https://doi.org/10.1007/978-3-540-68017-8_33
Publication status	Published - 2007
Event	3rd Kuala Lumpur International Conference on Biomedical Engineering, Biomed 2006 - Kuala Lumpur, Malaysia Duration: 2006 Dec 11 → 2006 Dec 14

Publication series

Name	IFMBE Proceedings
Volume	15
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Other

Other	3rd Kuala Lumpur International Conference on Biomedical Engineering, Biomed 2006
Country/Territory	Malaysia
City	Kuala Lumpur
Period	06/12/11 → 06/12/14

Bibliographical note

Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2007.

All Science Journal Classification (ASJC) codes

Bioengineering
Biomedical Engineering

Access to Document

10.1007/978-3-540-68017-8_33

Cite this

Lee, J. B., Mun, C. W., Choi, H. H., Park, J. C., Choi, J. B., & Kim, J. K. (2007). Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction. In F. Ibrahim, N. A. Abu Osman, J. Usman, & N. A. Kadri (Eds.), 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006 (pp. 130-133). (IFMBE Proceedings; Vol. 15). Springer Verlag. https://doi.org/10.1007/978-3-540-68017-8_33

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title = "Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction",

abstract = "PLGA (75:25)/hydroxyapatite (HA) composite films were fabricated by solvent-casting method to investigate the effect of various hydroxyapatite content ratio to the PLGA for mechanical properties, cellular attachment and proliferation. Mechanical property of the composite film was characterized by tensile test. The ultimate tensile strength of 10 wt% HA content film was two-fold higher than control group. Surface of the film was characterized by contact angle measurement and scanning electron microscope (SEM). The PLGA/HA composites were more hydrophilic than control. Chondrocyte responses to the composite films were measured in vitro by cellular attachment and proliferation test. The attached and proliferated cells were significantly higher on PLGA/HA (10 wt%) composite film than control group (1.44 times higher in attachment test and 1.31 times higher for 6thday at culture in proliferation assaying, p<0.05).",

author = "Lee, {J. B.} and Mun, {C. W.} and Choi, {H. H.} and Park, {J. C.} and Choi, {J. B.} and Kim, {Jeong Koo}",

note = "Publisher Copyright: {\textcopyright} Springer-Verlag Berlin Heidelberg 2007.; 3rd Kuala Lumpur International Conference on Biomedical Engineering, Biomed 2006 ; Conference date: 11-12-2006 Through 14-12-2006",

year = "2007",

doi = "10.1007/978-3-540-68017-8_33",

language = "English",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

pages = "130--133",

editor = "Fatimah Ibrahim and {Abu Osman}, {Noor Azuan} and Juliana Usman and Kadri, {Nahrizul Adib}",

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Lee, JB, Mun, CW, Choi, HH, Park, JC, Choi, JB & Kim, JK 2007, Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction. in F Ibrahim, NA Abu Osman, J Usman & NA Kadri (eds), 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006. IFMBE Proceedings, vol. 15, Springer Verlag, pp. 130-133, 3rd Kuala Lumpur International Conference on Biomedical Engineering, Biomed 2006, Kuala Lumpur, Malaysia, 06/12/11. https://doi.org/10.1007/978-3-540-68017-8_33

Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction. / Lee, J. B.; Mun, C. W.; Choi, H. H. et al.

3rd Kuala Lumpur International Conference on Biomedical Engineering 2006. ed. / Fatimah Ibrahim; Noor Azuan Abu Osman; Juliana Usman; Nahrizul Adib Kadri. Springer Verlag, 2007. p. 130-133 (IFMBE Proceedings; Vol. 15).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction

AU - Lee, J. B.

AU - Mun, C. W.

AU - Choi, H. H.

AU - Park, J. C.

AU - Choi, J. B.

AU - Kim, Jeong Koo

N1 - Publisher Copyright: © Springer-Verlag Berlin Heidelberg 2007.

PY - 2007

Y1 - 2007

N2 - PLGA (75:25)/hydroxyapatite (HA) composite films were fabricated by solvent-casting method to investigate the effect of various hydroxyapatite content ratio to the PLGA for mechanical properties, cellular attachment and proliferation. Mechanical property of the composite film was characterized by tensile test. The ultimate tensile strength of 10 wt% HA content film was two-fold higher than control group. Surface of the film was characterized by contact angle measurement and scanning electron microscope (SEM). The PLGA/HA composites were more hydrophilic than control. Chondrocyte responses to the composite films were measured in vitro by cellular attachment and proliferation test. The attached and proliferated cells were significantly higher on PLGA/HA (10 wt%) composite film than control group (1.44 times higher in attachment test and 1.31 times higher for 6thday at culture in proliferation assaying, p<0.05).

AB - PLGA (75:25)/hydroxyapatite (HA) composite films were fabricated by solvent-casting method to investigate the effect of various hydroxyapatite content ratio to the PLGA for mechanical properties, cellular attachment and proliferation. Mechanical property of the composite film was characterized by tensile test. The ultimate tensile strength of 10 wt% HA content film was two-fold higher than control group. Surface of the film was characterized by contact angle measurement and scanning electron microscope (SEM). The PLGA/HA composites were more hydrophilic than control. Chondrocyte responses to the composite films were measured in vitro by cellular attachment and proliferation test. The attached and proliferated cells were significantly higher on PLGA/HA (10 wt%) composite film than control group (1.44 times higher in attachment test and 1.31 times higher for 6thday at culture in proliferation assaying, p<0.05).

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T3 - IFMBE Proceedings

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EP - 133

BT - 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006

A2 - Ibrahim, Fatimah

A2 - Abu Osman, Noor Azuan

A2 - Usman, Juliana

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PB - Springer Verlag

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Y2 - 11 December 2006 through 14 December 2006

ER -

Lee JB, Mun CW, Choi HH, Park JC, Choi JB, Kim JK. Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction. In Ibrahim F, Abu Osman NA, Usman J, Kadri NA, editors, 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006. Springer Verlag. 2007. p. 130-133. (IFMBE Proceedings). doi: 10.1007/978-3-540-68017-8_33

Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction

Abstract

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Bibliographical note

All Science Journal Classification (ASJC) codes

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