Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction

J. B. Lee, C. W. Mun, H. H. Choi, J. C. Park, J. B. Choi, Jeong Koo Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

PLGA (75:25)/hydroxyapatite (HA) composite films were fabricated by solvent-casting method to investigate the effect of various hydroxyapatite content ratio to the PLGA for mechanical properties, cellular attachment and proliferation. Mechanical property of the composite film was characterized by tensile test. The ultimate tensile strength of 10 wt% HA content film was two-fold higher than control group. Surface of the film was characterized by contact angle measurement and scanning electron microscope (SEM). The PLGA/HA composites were more hydrophilic than control. Chondrocyte responses to the composite films were measured in vitro by cellular attachment and proliferation test. The attached and proliferated cells were significantly higher on PLGA/HA (10 wt%) composite film than control group (1.44 times higher in attachment test and 1.31 times higher for 6thday at culture in proliferation assaying, p<0.05).

Original languageEnglish
Title of host publication3rd Kuala Lumpur International Conference on Biomedical Engineering 2006
EditorsFatimah Ibrahim, Noor Azuan Abu Osman, Juliana Usman, Nahrizul Adib Kadri
PublisherSpringer Verlag
Pages130-133
Number of pages4
ISBN (Electronic)9783540680161
Publication statusPublished - 2007 Jan 1
Event3rd Kuala Lumpur International Conference on Biomedical Engineering, Biomed 2006 - Kuala Lumpur, Malaysia
Duration: 2006 Dec 112006 Dec 14

Publication series

NameIFMBE Proceedings
Volume15
ISSN (Print)1680-0737

Other

Other3rd Kuala Lumpur International Conference on Biomedical Engineering, Biomed 2006
CountryMalaysia
CityKuala Lumpur
Period06/12/1106/12/14

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All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Lee, J. B., Mun, C. W., Choi, H. H., Park, J. C., Choi, J. B., & Kim, J. K. (2007). Poly (Lactic–co–glycolic acid) and hydroxyapatite composite films for cartilage reconstruction. In F. Ibrahim, N. A. Abu Osman, J. Usman, & N. A. Kadri (Eds.), 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006 (pp. 130-133). (IFMBE Proceedings; Vol. 15). Springer Verlag.