Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy

Man Jeong Paik, Young Hwan Ahn, Phil Hyu Lee, Hyunseung Kang, Chan Bae Park, Sangdun Choi, Gwang Lee

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Methods: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/. N-pentafluoropropyonyl derivatives. Results: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N1-acetylspermidine, and putrescine spermidine-1 were significantly increased, whereas the concentration of spermidine was significantly reduced. Conclusions: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.

Original languageEnglish
Pages (from-to)1532-1535
Number of pages4
JournalClinica Chimica Acta
Volume411
Issue number19-20
DOIs
Publication statusPublished - 2010 Oct 1

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Cerebrospinal fluid
Multiple System Atrophy
Polyamines
Parkinson Disease
Cerebrospinal Fluid
Putrescine
Spermidine
Neurodegenerative diseases
Neurodegenerative Diseases
Gas chromatography
Gas Chromatography-Mass Spectrometry
Modulators
Mass spectrometry
Ions
Derivatives
Monitoring

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Paik, Man Jeong ; Ahn, Young Hwan ; Lee, Phil Hyu ; Kang, Hyunseung ; Park, Chan Bae ; Choi, Sangdun ; Lee, Gwang. / Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy. In: Clinica Chimica Acta. 2010 ; Vol. 411, No. 19-20. pp. 1532-1535.
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Polyamine patterns in the cerebrospinal fluid of patients with Parkinson's disease and multiple system atrophy. / Paik, Man Jeong; Ahn, Young Hwan; Lee, Phil Hyu; Kang, Hyunseung; Park, Chan Bae; Choi, Sangdun; Lee, Gwang.

In: Clinica Chimica Acta, Vol. 411, No. 19-20, 01.10.2010, p. 1532-1535.

Research output: Contribution to journalArticle

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AU - Paik, Man Jeong

AU - Ahn, Young Hwan

AU - Lee, Phil Hyu

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AU - Park, Chan Bae

AU - Choi, Sangdun

AU - Lee, Gwang

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AB - Background: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Methods: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/. N-pentafluoropropyonyl derivatives. Results: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N1-acetylspermidine, and putrescine spermidine-1 were significantly increased, whereas the concentration of spermidine was significantly reduced. Conclusions: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.

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