Background: Polyamines (PAs) are important modulators of physiological condition, and are associated with neurodegenerative disease. Thus, we investigated the change of PA concentration in the cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Methods: CSF samples from patients with PD and MSA were examined by gas chromatography-mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/. N-pentafluoropropyonyl derivatives. Results: PA concentrations were significantly different in patients with PD and MSA compared with those in the normal group. In the PD group, as compared with the MSA group, concentrations of putrescine, N1-acetylspermidine, and putrescine spermidine-1 were significantly increased, whereas the concentration of spermidine was significantly reduced. Conclusions: These results could be helpful for understanding the complexity of biochemical events in patients with PD and MSA, and may serve as metabolic markers for diagnosis of PD and MSA.
Bibliographical noteFunding Information:
T his work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2007-313-H00012) to G.L., Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093826), and the Korea Research Foundation (KRF) grant funded by the Korea government (MEST) (No. 2010-0016256) to S.C.
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Biochemistry, medical