A modular approach to 5-acylated naphtho[2,1-b]benzofurans was developed where Sonogashira cross-coupling and intramolecular alkyne carbonyl metathesis were sequentially employed to build the aromatic benzene C ring of naphtho[2,1-b]benzofuran with an acyl group at the C5 position.
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation of Korea grant funded by the Korea government (MSIP) (2014R1A2A1A11050491).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry