Polygonum aviculare L. is a member of the Polygonaceae family of plants, which has been known for its antioxidant and anti-obesity effects. However, the wound healing function of P. aviculare extract has not been assessed. In this study, we identified a novel property of P. aviculare extract as a Wnt/β-catenin pathway activator based on a screen of 350 plant extracts using HEK293-TOP cells retaining the Wnt/β-catenin signaling reporter gene. P. aviculare extract accelerated the migration of HaCaT keratinocytes without showing significant cytotoxicity. Moreover, P. aviculare extract efficiently re-epithelized wounds generated on mice. Additionally, ingredients of P. aviculare extract, such as quercitrin hydrate, caffeic acid, and rutin, also accelerated the motility of HaCaT keratinocytes with the activation of Wnt/β-catenin signaling. Therefore, based on our findings, P. aviculare extract and its active ingredients could be potential therapeutic agents for wound healing.
Bibliographical noteFunding Information:
This work was supported by grants from the National Research Foundation (NRF), funded by the Ministry of Future Creation and Science (MFCS) of Korea; Mid-career Researcher Program (2012R1A2A1A01010285); and Translational Research Center for Protein Function Control (2009-0083522). This work was also partly supported by a grant from Handok Pharmaceuticals Co., Ltd. Seol Hwa Seo was supported by a BK21 PLUS studentship from the National Research Foundation.
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