Polyion complex micelle formed from tetraphenylethene containing block copolymer

Seong Min Lee, Woo Dong Jang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle. Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy. Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light.

Original languageEnglish
Article number17
JournalBiomaterials Research
Volume21
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Micelles
Block copolymers
Polyetherimides
Polyethylene glycols
Agglomeration
Dynamic light scattering
Transmission Electron Microscopy
Transmission electron microscopy
Light
Dendrimers
Halogens
Porphyrins
Light transmission
Lighting
Drug delivery
Electric lamps
HeLa Cells
Functional groups

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Medicine (miscellaneous)

Cite this

@article{e2cb8a3c8db24926b053e04a533c1fa5,
title = "Polyion complex micelle formed from tetraphenylethene containing block copolymer",
abstract = "Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle. Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy. Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light.",
author = "Lee, {Seong Min} and Jang, {Woo Dong}",
year = "2017",
month = "1",
day = "1",
doi = "10.1186/s40824-017-0103-9",
language = "English",
volume = "21",
journal = "Biomaterials Research",
issn = "2055-7124",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

Polyion complex micelle formed from tetraphenylethene containing block copolymer. / Lee, Seong Min; Jang, Woo Dong.

In: Biomaterials Research, Vol. 21, No. 1, 17, 01.01.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polyion complex micelle formed from tetraphenylethene containing block copolymer

AU - Lee, Seong Min

AU - Jang, Woo Dong

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle. Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy. Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light.

AB - Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle. Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy. Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light.

UR - http://www.scopus.com/inward/record.url?scp=85030983030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030983030&partnerID=8YFLogxK

U2 - 10.1186/s40824-017-0103-9

DO - 10.1186/s40824-017-0103-9

M3 - Article

AN - SCOPUS:85030983030

VL - 21

JO - Biomaterials Research

JF - Biomaterials Research

SN - 2055-7124

IS - 1

M1 - 17

ER -