Polyion complex micelles for photodynamic therapy: Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property

Woo Dong Jang, Yoshinori Nakagishi, Nobuhiro Nishiyama, Satoko Kawauchi, Yuji Morimoto, Makoto Kikuchi, Kazunori Kataoka

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(l-lysine) block copolymers (PEG-b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic light scattering studies indicated that the DPcZn/m system has a relevant size of 50 nm for intravenous administration. Under light irradiation, either DPcZn or DPcZn/m exhibited efficient consumption of dissolved oxygen in a medium to generate reactive oxygen species and an irradiation-time-dependent increase in photocytotoxicity. The photodynamic efficacy of the DPcZn was drastically improved by the incorporation into the polymeric micelles, typically exhibiting more than two orders of magnitude higher photocytotoxicity compared with the free DPcZn at 60-min photoirradiation.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalJournal of Controlled Release
Volume113
Issue number1
DOIs
Publication statusPublished - 2006 Jun 12

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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