TY - JOUR
T1 - Polyion complex micelles for photodynamic therapy
T2 - Incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property
AU - Jang, Woo Dong
AU - Nakagishi, Yoshinori
AU - Nishiyama, Nobuhiro
AU - Kawauchi, Satoko
AU - Morimoto, Yuji
AU - Kikuchi, Makoto
AU - Kataoka, Kazunori
N1 - Funding Information:
This study was supported by Industrial Technology Research Grant Program in 2004 from New Energy and Industrial Technology Development Organization (NEDO) of Japan.
PY - 2006/6/12
Y1 - 2006/6/12
N2 - A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(l-lysine) block copolymers (PEG-b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic light scattering studies indicated that the DPcZn/m system has a relevant size of 50 nm for intravenous administration. Under light irradiation, either DPcZn or DPcZn/m exhibited efficient consumption of dissolved oxygen in a medium to generate reactive oxygen species and an irradiation-time-dependent increase in photocytotoxicity. The photodynamic efficacy of the DPcZn was drastically improved by the incorporation into the polymeric micelles, typically exhibiting more than two orders of magnitude higher photocytotoxicity compared with the free DPcZn at 60-min photoirradiation.
AB - A polymeric micelle (DPcZn/m) system, which is formed via an electrostatic interaction of anionic dendrimer phthalocyanine (DPcZn) and poly(ethylene glycol)-poly(l-lysine) block copolymers (PEG-b-PLL), was prepared for use as an effective photosensitizer for photodynamic therapy. DPcZn/m exhibited strong Q band absorption around 650 nm, a useful wavelength for high tissue penetration. Dynamic light scattering studies indicated that the DPcZn/m system has a relevant size of 50 nm for intravenous administration. Under light irradiation, either DPcZn or DPcZn/m exhibited efficient consumption of dissolved oxygen in a medium to generate reactive oxygen species and an irradiation-time-dependent increase in photocytotoxicity. The photodynamic efficacy of the DPcZn was drastically improved by the incorporation into the polymeric micelles, typically exhibiting more than two orders of magnitude higher photocytotoxicity compared with the free DPcZn at 60-min photoirradiation.
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U2 - 10.1016/j.jconrel.2006.03.009
DO - 10.1016/j.jconrel.2006.03.009
M3 - Article
C2 - 16701915
AN - SCOPUS:33744536976
SN - 0168-3659
VL - 113
SP - 73
EP - 79
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -