Polymer-metal complex micelles for the combination of sustained drug releasing and photodynamic therapy

Jongsu Kim, Hee Jae Yoon, Suhyun Kim, Kangkyun Wang, Takehiko Ishii, Yong Rok Kim, Woo Dong Jang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Polymer-metal complex micelles (PMCMs) containing cisplatin (cis-dichlorodiammineplatinum(ii), CDDP), an anticancer drug, were prepared by a coordination bond of CDDP to dendrimer phthalocyanine (DPc) and poly(ethylene glycol)-block-poly(l-aspartic acid) (PEG-PLAn; molecular weight of PEG segment = 12000 g mol-1; polymerization degrees of aspartic acid segment n = 68, 96). Transmission electron microscopy (TEM) and laser light scattering (LLS) exhibited formation of unimodal PMCM68 and PMCM96 with average sizes of 108 and 135 nm, respectively. PMCMs were very stable in 10 mM phosphate buffer solution (PBS) without NaCl to maintain their shape and size over a month. However, PMCMs slowly released CDDP when they were incubated in physiological saline PBS solution at 37 °C. Upon laser light irradiation, generation of singlet oxygen was detected by photo-luminescence observation. The PMCMs would be effective nano-devices for anticancer drug carriers with sustained drug release and photodynamic therapy (PDT).

Original languageEnglish
Pages (from-to)4627-4631
Number of pages5
JournalJournal of Materials Chemistry
Volume19
Issue number26
DOIs
Publication statusPublished - 2009 Jul 9

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Chemistry

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