Polymer-metal complex micelles for the combination of sustained drug releasing and photodynamic therapy

Jongsu Kim; Hee Jae Yoon; Suhyun Kim; Kangkyun Wang; Takehiko Ishii; Yong Rok Kim; Woo Dong Jang

doi:10.1039/b904224e

Polymer-metal complex micelles for the combination of sustained drug releasing and photodynamic therapy

Jongsu Kim, Hee Jae Yoon, Suhyun Kim, Kangkyun Wang, Takehiko Ishii, Yong Rok Kim, Woo Dong Jang

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Polymer-metal complex micelles (PMCMs) containing cisplatin (cis-dichlorodiammineplatinum(ii), CDDP), an anticancer drug, were prepared by a coordination bond of CDDP to dendrimer phthalocyanine (DPc) and poly(ethylene glycol)-block-poly(l-aspartic acid) (PEG-PLAn; molecular weight of PEG segment = 12000 g mol^-1; polymerization degrees of aspartic acid segment n = 68, 96). Transmission electron microscopy (TEM) and laser light scattering (LLS) exhibited formation of unimodal PMCM₆₈ and PMCM₉₆ with average sizes of 108 and 135 nm, respectively. PMCMs were very stable in 10 mM phosphate buffer solution (PBS) without NaCl to maintain their shape and size over a month. However, PMCMs slowly released CDDP when they were incubated in physiological saline PBS solution at 37 °C. Upon laser light irradiation, generation of singlet oxygen was detected by photo-luminescence observation. The PMCMs would be effective nano-devices for anticancer drug carriers with sustained drug release and photodynamic therapy (PDT).

Original language	English
Pages (from-to)	4627-4631
Number of pages	5
Journal	Journal of Materials Chemistry
Volume	19
Issue number	26
DOIs	https://doi.org/10.1039/b904224e
Publication status	Published - 2009

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Chemistry

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title = "Polymer-metal complex micelles for the combination of sustained drug releasing and photodynamic therapy",

abstract = "Polymer-metal complex micelles (PMCMs) containing cisplatin (cis-dichlorodiammineplatinum(ii), CDDP), an anticancer drug, were prepared by a coordination bond of CDDP to dendrimer phthalocyanine (DPc) and poly(ethylene glycol)-block-poly(l-aspartic acid) (PEG-PLAn; molecular weight of PEG segment = 12000 g mol-1; polymerization degrees of aspartic acid segment n = 68, 96). Transmission electron microscopy (TEM) and laser light scattering (LLS) exhibited formation of unimodal PMCM68 and PMCM96 with average sizes of 108 and 135 nm, respectively. PMCMs were very stable in 10 mM phosphate buffer solution (PBS) without NaCl to maintain their shape and size over a month. However, PMCMs slowly released CDDP when they were incubated in physiological saline PBS solution at 37 °C. Upon laser light irradiation, generation of singlet oxygen was detected by photo-luminescence observation. The PMCMs would be effective nano-devices for anticancer drug carriers with sustained drug release and photodynamic therapy (PDT).",

author = "Jongsu Kim and Yoon, {Hee Jae} and Suhyun Kim and Kangkyun Wang and Takehiko Ishii and Kim, {Yong Rok} and Jang, {Woo Dong}",

year = "2009",

doi = "10.1039/b904224e",

language = "English",

volume = "19",

pages = "4627--4631",

journal = "Journal of Materials Chemistry",

issn = "0959-9428",

publisher = "Royal Society of Chemistry",

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T1 - Polymer-metal complex micelles for the combination of sustained drug releasing and photodynamic therapy

AU - Kim, Jongsu

AU - Yoon, Hee Jae

AU - Kim, Suhyun

AU - Wang, Kangkyun

AU - Ishii, Takehiko

AU - Kim, Yong Rok

AU - Jang, Woo Dong

PY - 2009

Y1 - 2009

N2 - Polymer-metal complex micelles (PMCMs) containing cisplatin (cis-dichlorodiammineplatinum(ii), CDDP), an anticancer drug, were prepared by a coordination bond of CDDP to dendrimer phthalocyanine (DPc) and poly(ethylene glycol)-block-poly(l-aspartic acid) (PEG-PLAn; molecular weight of PEG segment = 12000 g mol-1; polymerization degrees of aspartic acid segment n = 68, 96). Transmission electron microscopy (TEM) and laser light scattering (LLS) exhibited formation of unimodal PMCM68 and PMCM96 with average sizes of 108 and 135 nm, respectively. PMCMs were very stable in 10 mM phosphate buffer solution (PBS) without NaCl to maintain their shape and size over a month. However, PMCMs slowly released CDDP when they were incubated in physiological saline PBS solution at 37 °C. Upon laser light irradiation, generation of singlet oxygen was detected by photo-luminescence observation. The PMCMs would be effective nano-devices for anticancer drug carriers with sustained drug release and photodynamic therapy (PDT).

AB - Polymer-metal complex micelles (PMCMs) containing cisplatin (cis-dichlorodiammineplatinum(ii), CDDP), an anticancer drug, were prepared by a coordination bond of CDDP to dendrimer phthalocyanine (DPc) and poly(ethylene glycol)-block-poly(l-aspartic acid) (PEG-PLAn; molecular weight of PEG segment = 12000 g mol-1; polymerization degrees of aspartic acid segment n = 68, 96). Transmission electron microscopy (TEM) and laser light scattering (LLS) exhibited formation of unimodal PMCM68 and PMCM96 with average sizes of 108 and 135 nm, respectively. PMCMs were very stable in 10 mM phosphate buffer solution (PBS) without NaCl to maintain their shape and size over a month. However, PMCMs slowly released CDDP when they were incubated in physiological saline PBS solution at 37 °C. Upon laser light irradiation, generation of singlet oxygen was detected by photo-luminescence observation. The PMCMs would be effective nano-devices for anticancer drug carriers with sustained drug release and photodynamic therapy (PDT).

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DO - 10.1039/b904224e

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JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 26

ER -

Polymer-metal complex micelles for the combination of sustained drug releasing and photodynamic therapy

Abstract

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