Polymeric microspheres: a delivery system for osteogenic differentiation

Rajkumar Patel, Madhumita Patel, Jeonghun Kwak, Arun K. Iyer, Rajshekhar Karpoormath, Shrojal Desai, Vimal Rarh

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Advanced drug delivery systems employing controlled release technology are being developed to address many of the difficulties associated with traditional methods of drug administration. Controlled release technology involves the use of devices such as polymer-based disks, rods, pellets, or microspheres (MSs) that encapsulate drugs, genes, cytokines, and growth factors and release them in specific location within the body in a controlled fashion, for relatively long periods of time. Among these, microencapsulation is one of the core technologies used in polymer-based drug delivery systems. In this regard, MS serves as microcarriers for sustain drug release facilitating their use for invasive or minimally invasive treatment. MS has significant potential for the application in bone repair, intra-articular treatment of osteoarthritis, and biological bone growth. The present review compiles the recent advances in polymeric MS for application in bone and cartilage regeneration.

Original languageEnglish
Pages (from-to)1595-1609
Number of pages15
JournalPolymers for Advanced Technologies
Volume28
Issue number12
DOIs
Publication statusPublished - 2017 Dec

Bibliographical note

Publisher Copyright:
Copyright © 2017 John Wiley & Sons, Ltd.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics

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