Polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications

Hongsik Yoon, Emma J. Dell, Jessica L. Freyer, Luis M. Campos, Woo Dong Jang

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Oppositely charged polyelectrolytes can be used to form various types of self-assembled structures directed by multivalent ionic interactions. The supramolecular architectures that result are often referred to as polyion complexes (PICs). Synthetic polyion complexes are exciting candidates for biomedical applications. Their self-assembly capabilities give rise to hierarchical mesoscopic platforms such as micelles, membranes, and capsules through simple mixing processes. These complexes are also ideal candidates for the transport and delivery of biological agents since biomolecules, such as DNA and proteins can be easily incorporated through ionic interactions. PICs have therefore found use in drug delivery, diagnostics, gene therapy, biosensors and microreactors. In this paper, we briefly review examples of polymeric supramolecular assemblies based on multivalent ionic interactions for biomedical applications.

Original languageEnglish
Pages (from-to)453-464
Number of pages12
Journalpolymer
Volume55
Issue number2
DOIs
Publication statusPublished - 2014 Jan 30

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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