Polymorphism in the cagA EPIYA motif impacts development of gastric cancer

Kathleen R. Jones, Young Min Joo, Sungil Jang, Yun Jung Yoo, Hak Sung Lee, In Sik Chung, Cara H. Olsen, Jeannette M. Whitmire, D. Scott Merrell, Jeong Heon Cha

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Abstract

Helicobacter pylori causes diseases ranging from gastritis to peptic ulcer disease to gastric cancer. Geographically, areas with high incidences of H. pylori infection often overlap with areas with high incidences of gastric cancer, which remains one of the leading causes of cancer-related deaths worldwide. Strains of H. pylori that carry the virulence factor cytotoxin-associated gene A (cagA) are much more likely to be associated with the development of gastric cancer. Moreover, particular C-terminal polymorphisms in CagA vary by geography and have been suggested to influence disease development. We conducted a large-scale molecular epidemiologic analysis of South Korean strains and herein report a statistical link between the East Asian CagA EPIYA-ABD genotype and the development of gastric cancer. Characterization of a subset of the Korean isolates showed that all strains from cancer patients expressed and delivered phosphorylatable CagA to host cells, whereas the presence of the cagA gene did not strictly correlate to expression and delivery of CagA in all noncancer strains.

Original languageEnglish
Pages (from-to)959-968
Number of pages10
JournalJournal of Clinical Microbiology
Volume47
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

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    Jones, K. R., Joo, Y. M., Jang, S., Yoo, Y. J., Lee, H. S., Chung, I. S., Olsen, C. H., Whitmire, J. M., Merrell, D. S., & Cha, J. H. (2009). Polymorphism in the cagA EPIYA motif impacts development of gastric cancer. Journal of Clinical Microbiology, 47(4), 959-968. https://doi.org/10.1128/JCM.02330-08