Polyphosphate blocks tumour metastasis via anti-angiogenic activity

Kyu Yeon Han, Bok Sil Hong, Yae Jin Yoon, Chang Min Yoon, Yoon Keun Kim, Young Guen Kwon, Yong Song Gho

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

PolyP (inorganic polyphosphate) is a linear polymer of many tens or hundreds of orthophosphate residues found in a wide range of organisms, including bacteria, fungi, insects, plants and vertebrates. Despite its wide distribution in mammalian tissues and plasma, the biological functions of polyP on tumour metastasis and angiogenesis have not been previously examined. In the present study, we have shown that polyP effectively blocked in vivo pulmonary metastasis of B16BL6 cells by suppression of neovascularization, whereas it did not affect proliferation or adhesion to extracellular matrix proteins. PolyP not only inhibited bFGF (basic fibroblast growth factor)-induced proliferation and ERK (extracellular-signal-regulated kinase)/p38 MAPK (mitogen-activated protein kinase) activation of human endothelial cells, but also blocked the binding of bFGF to its cognate cell-surface receptor. Furthermore, polyP inhibited bFGF-induced in vitro and in vivo angiogenesis, suggesting that polyP possesses an anti-angiogenic activity. Since neovascularization is essential for tumour metastasis, our present findings clearly indicate that polyP has an in vivo anti-metastatic activity via its anti-angiogenic activity. Taken together with the fact that angiogenesis occurs under various normal and pathological conditions, our observations suggest that endogenous polyP may play a critical role during embryonic development, wound healing and inflammation, as well as in the progress of pathological diseases such as rheumatoid arthritis and cancer.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalBiochemical Journal
Volume406
Issue number1
DOIs
Publication statusPublished - 2007 Aug 15

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Polyphosphates
Fibroblast Growth Factor 2
Polyps
Tumors
Neoplasm Metastasis
Neoplasms
Extracellular Matrix Proteins
Extracellular Signal-Regulated MAP Kinases
Endothelial cells
Cell Surface Receptors
p38 Mitogen-Activated Protein Kinases
Fungi
Bacteria
Polymers
Adhesion
Chemical activation
Phosphates
Tissue
Plasmas
Wound Healing

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Han, K. Y., Hong, B. S., Yoon, Y. J., Yoon, C. M., Kim, Y. K., Kwon, Y. G., & Gho, Y. S. (2007). Polyphosphate blocks tumour metastasis via anti-angiogenic activity. Biochemical Journal, 406(1), 49-55. https://doi.org/10.1042/BJ20061542
Han, Kyu Yeon ; Hong, Bok Sil ; Yoon, Yae Jin ; Yoon, Chang Min ; Kim, Yoon Keun ; Kwon, Young Guen ; Gho, Yong Song. / Polyphosphate blocks tumour metastasis via anti-angiogenic activity. In: Biochemical Journal. 2007 ; Vol. 406, No. 1. pp. 49-55.
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Han, KY, Hong, BS, Yoon, YJ, Yoon, CM, Kim, YK, Kwon, YG & Gho, YS 2007, 'Polyphosphate blocks tumour metastasis via anti-angiogenic activity', Biochemical Journal, vol. 406, no. 1, pp. 49-55. https://doi.org/10.1042/BJ20061542

Polyphosphate blocks tumour metastasis via anti-angiogenic activity. / Han, Kyu Yeon; Hong, Bok Sil; Yoon, Yae Jin; Yoon, Chang Min; Kim, Yoon Keun; Kwon, Young Guen; Gho, Yong Song.

In: Biochemical Journal, Vol. 406, No. 1, 15.08.2007, p. 49-55.

Research output: Contribution to journalArticle

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T1 - Polyphosphate blocks tumour metastasis via anti-angiogenic activity

AU - Han, Kyu Yeon

AU - Hong, Bok Sil

AU - Yoon, Yae Jin

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AU - Gho, Yong Song

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