Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy

Jung Rim Yoon, Eun Joo Lee, HeungDong Kim, Jae Hwan Lee, hoonchul kang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The ketogenic diet (KD) is a high-fat, low-carbohydrate diet with an established efficacy for treating medically refractory epilepsy in children. Fatty acids are the most important constituent of the KD in all aspects of efficacy and complications. Among fatty acids, polyunsaturated fatty acids (PUFAs) increase anticonvulsant properties and reduce the complications associated with the high-fat diet. Here, we report a 7-year-old boy with Lennox-Gastaut syndrome combined with mitochondrial respiratory chain complex I deficiency, whose medically intractable seizures have been successfully controlled with a PUFA-enriched modified Atkins diet without any significant adverse events. The diet consists of canola oil and diverse menu items like fish and nuts instead of olive oil and has an ideal 1:2.8 ratio of omega-3 to omega-6. In addition, fractionation of this boy's plasma showed normal levels of fatty acids, including omega-3 (alpha-linoleic acid, eicosapentaenoic acid) and omega-6 (linoleic acid, arachidonic acid) as well as monounsaturated fatty acids (oleic acid). Plasma docosahexanoic acid remained low after PUFA-enriched diet therapy. PUFA-enriched diet therapy is likely to increase the efficacy of diet therapy and reduce complications of a high-fat diet in children with refractory epilepsy.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalBrain and Development
Volume36
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

Fingerprint

Diet Therapy
Unsaturated Fatty Acids
Epilepsy
Ketogenic Diet
Carbohydrate-Restricted Diet
High Fat Diet
Linoleic Acid
Fatty Acids
Electron Transport Complex I
Monounsaturated Fatty Acids
Nuts
Eicosapentaenoic Acid
Omega-3 Fatty Acids
Oleic Acid
Electron Transport
Arachidonic Acid
Anticonvulsants
Fishes
Seizures
Fats

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Developmental Neuroscience
  • Pediatrics, Perinatology, and Child Health

Cite this

Yoon, Jung Rim ; Lee, Eun Joo ; Kim, HeungDong ; Lee, Jae Hwan ; kang, hoonchul. / Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy. In: Brain and Development. 2014 ; Vol. 36, No. 2. pp. 163-166.
@article{1c047dea101a4b5b978c1e3053bcfbc2,
title = "Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy",
abstract = "The ketogenic diet (KD) is a high-fat, low-carbohydrate diet with an established efficacy for treating medically refractory epilepsy in children. Fatty acids are the most important constituent of the KD in all aspects of efficacy and complications. Among fatty acids, polyunsaturated fatty acids (PUFAs) increase anticonvulsant properties and reduce the complications associated with the high-fat diet. Here, we report a 7-year-old boy with Lennox-Gastaut syndrome combined with mitochondrial respiratory chain complex I deficiency, whose medically intractable seizures have been successfully controlled with a PUFA-enriched modified Atkins diet without any significant adverse events. The diet consists of canola oil and diverse menu items like fish and nuts instead of olive oil and has an ideal 1:2.8 ratio of omega-3 to omega-6. In addition, fractionation of this boy's plasma showed normal levels of fatty acids, including omega-3 (alpha-linoleic acid, eicosapentaenoic acid) and omega-6 (linoleic acid, arachidonic acid) as well as monounsaturated fatty acids (oleic acid). Plasma docosahexanoic acid remained low after PUFA-enriched diet therapy. PUFA-enriched diet therapy is likely to increase the efficacy of diet therapy and reduce complications of a high-fat diet in children with refractory epilepsy.",
author = "Yoon, {Jung Rim} and Lee, {Eun Joo} and HeungDong Kim and Lee, {Jae Hwan} and hoonchul kang",
year = "2014",
month = "2",
day = "1",
doi = "10.1016/j.braindev.2013.01.017",
language = "English",
volume = "36",
pages = "163--166",
journal = "Brain and Development",
issn = "0387-7604",
publisher = "Elsevier",
number = "2",

}

Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy. / Yoon, Jung Rim; Lee, Eun Joo; Kim, HeungDong; Lee, Jae Hwan; kang, hoonchul.

In: Brain and Development, Vol. 36, No. 2, 01.02.2014, p. 163-166.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polyunsaturated fatty acid-enriched diet therapy for a child with epilepsy

AU - Yoon, Jung Rim

AU - Lee, Eun Joo

AU - Kim, HeungDong

AU - Lee, Jae Hwan

AU - kang, hoonchul

PY - 2014/2/1

Y1 - 2014/2/1

N2 - The ketogenic diet (KD) is a high-fat, low-carbohydrate diet with an established efficacy for treating medically refractory epilepsy in children. Fatty acids are the most important constituent of the KD in all aspects of efficacy and complications. Among fatty acids, polyunsaturated fatty acids (PUFAs) increase anticonvulsant properties and reduce the complications associated with the high-fat diet. Here, we report a 7-year-old boy with Lennox-Gastaut syndrome combined with mitochondrial respiratory chain complex I deficiency, whose medically intractable seizures have been successfully controlled with a PUFA-enriched modified Atkins diet without any significant adverse events. The diet consists of canola oil and diverse menu items like fish and nuts instead of olive oil and has an ideal 1:2.8 ratio of omega-3 to omega-6. In addition, fractionation of this boy's plasma showed normal levels of fatty acids, including omega-3 (alpha-linoleic acid, eicosapentaenoic acid) and omega-6 (linoleic acid, arachidonic acid) as well as monounsaturated fatty acids (oleic acid). Plasma docosahexanoic acid remained low after PUFA-enriched diet therapy. PUFA-enriched diet therapy is likely to increase the efficacy of diet therapy and reduce complications of a high-fat diet in children with refractory epilepsy.

AB - The ketogenic diet (KD) is a high-fat, low-carbohydrate diet with an established efficacy for treating medically refractory epilepsy in children. Fatty acids are the most important constituent of the KD in all aspects of efficacy and complications. Among fatty acids, polyunsaturated fatty acids (PUFAs) increase anticonvulsant properties and reduce the complications associated with the high-fat diet. Here, we report a 7-year-old boy with Lennox-Gastaut syndrome combined with mitochondrial respiratory chain complex I deficiency, whose medically intractable seizures have been successfully controlled with a PUFA-enriched modified Atkins diet without any significant adverse events. The diet consists of canola oil and diverse menu items like fish and nuts instead of olive oil and has an ideal 1:2.8 ratio of omega-3 to omega-6. In addition, fractionation of this boy's plasma showed normal levels of fatty acids, including omega-3 (alpha-linoleic acid, eicosapentaenoic acid) and omega-6 (linoleic acid, arachidonic acid) as well as monounsaturated fatty acids (oleic acid). Plasma docosahexanoic acid remained low after PUFA-enriched diet therapy. PUFA-enriched diet therapy is likely to increase the efficacy of diet therapy and reduce complications of a high-fat diet in children with refractory epilepsy.

UR - http://www.scopus.com/inward/record.url?scp=84891631736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891631736&partnerID=8YFLogxK

U2 - 10.1016/j.braindev.2013.01.017

DO - 10.1016/j.braindev.2013.01.017

M3 - Article

C2 - 23465587

AN - SCOPUS:84891631736

VL - 36

SP - 163

EP - 166

JO - Brain and Development

JF - Brain and Development

SN - 0387-7604

IS - 2

ER -