Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis

Kyung Wook Jo, Kyeongman Jeon, Young Ae Kang, Won Jung Koh, Kyung Chan Kim, Yee Hyung Kim, Kwang Ha Yoo, Seung Heon Lee, Jae Joon Yim, Sang Bong Choi, Won Il Choi, Jae Chol Choi, Yong Il Hwang, Tae Sun Shim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background and Objective: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). Methods: Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. Results: Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29). Conclusion: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination. There was a discrepancy between results of TSTs and QFT-GIT assays in close contacts of patients with multidrug-resistant tuberculosis, particularly those who had received BCG vaccination. These findings were similar to those from studies reporting poor correlation between these tests in close contacts of South Korean patients with drug-susceptible tuberculosis.

Original languageEnglish
Pages (from-to)1125-1130
Number of pages6
JournalRespirology
Volume17
Issue number7
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Multidrug-Resistant Tuberculosis
Tuberculin Test
Skin Tests
Gold
Interferons
Vaccination
Tuberculosis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Jo, Kyung Wook ; Jeon, Kyeongman ; Kang, Young Ae ; Koh, Won Jung ; Kim, Kyung Chan ; Kim, Yee Hyung ; Yoo, Kwang Ha ; Lee, Seung Heon ; Yim, Jae Joon ; Choi, Sang Bong ; Choi, Won Il ; Choi, Jae Chol ; Hwang, Yong Il ; Shim, Tae Sun. / Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis. In: Respirology. 2012 ; Vol. 17, No. 7. pp. 1125-1130.
@article{6467fabfb5ca409f86dbc18568421827,
title = "Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis",
abstract = "Background and Objective: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). Methods: Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2{\%}) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. Results: Forty-eight subjects (47.5{\%}) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5{\%}) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8{\%}) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5{\%}) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29). Conclusion: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination. There was a discrepancy between results of TSTs and QFT-GIT assays in close contacts of patients with multidrug-resistant tuberculosis, particularly those who had received BCG vaccination. These findings were similar to those from studies reporting poor correlation between these tests in close contacts of South Korean patients with drug-susceptible tuberculosis.",
author = "Jo, {Kyung Wook} and Kyeongman Jeon and Kang, {Young Ae} and Koh, {Won Jung} and Kim, {Kyung Chan} and Kim, {Yee Hyung} and Yoo, {Kwang Ha} and Lee, {Seung Heon} and Yim, {Jae Joon} and Choi, {Sang Bong} and Choi, {Won Il} and Choi, {Jae Chol} and Hwang, {Yong Il} and Shim, {Tae Sun}",
year = "2012",
month = "10",
day = "1",
doi = "10.1111/j.1440-1843.2012.02218.x",
language = "English",
volume = "17",
pages = "1125--1130",
journal = "Respirology",
issn = "1323-7799",
publisher = "Wiley-Blackwell",
number = "7",

}

Jo, KW, Jeon, K, Kang, YA, Koh, WJ, Kim, KC, Kim, YH, Yoo, KH, Lee, SH, Yim, JJ, Choi, SB, Choi, WI, Choi, JC, Hwang, YI & Shim, TS 2012, 'Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis', Respirology, vol. 17, no. 7, pp. 1125-1130. https://doi.org/10.1111/j.1440-1843.2012.02218.x

Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis. / Jo, Kyung Wook; Jeon, Kyeongman; Kang, Young Ae; Koh, Won Jung; Kim, Kyung Chan; Kim, Yee Hyung; Yoo, Kwang Ha; Lee, Seung Heon; Yim, Jae Joon; Choi, Sang Bong; Choi, Won Il; Choi, Jae Chol; Hwang, Yong Il; Shim, Tae Sun.

In: Respirology, Vol. 17, No. 7, 01.10.2012, p. 1125-1130.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Poor correlation between tuberculin skin tests and interferon-γ assays in close contacts of patients with multidrug-resistant tuberculosis

AU - Jo, Kyung Wook

AU - Jeon, Kyeongman

AU - Kang, Young Ae

AU - Koh, Won Jung

AU - Kim, Kyung Chan

AU - Kim, Yee Hyung

AU - Yoo, Kwang Ha

AU - Lee, Seung Heon

AU - Yim, Jae Joon

AU - Choi, Sang Bong

AU - Choi, Won Il

AU - Choi, Jae Chol

AU - Hwang, Yong Il

AU - Shim, Tae Sun

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background and Objective: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). Methods: Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. Results: Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29). Conclusion: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination. There was a discrepancy between results of TSTs and QFT-GIT assays in close contacts of patients with multidrug-resistant tuberculosis, particularly those who had received BCG vaccination. These findings were similar to those from studies reporting poor correlation between these tests in close contacts of South Korean patients with drug-susceptible tuberculosis.

AB - Background and Objective: The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB). Methods: Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients. Results: Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29). Conclusion: The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination. There was a discrepancy between results of TSTs and QFT-GIT assays in close contacts of patients with multidrug-resistant tuberculosis, particularly those who had received BCG vaccination. These findings were similar to those from studies reporting poor correlation between these tests in close contacts of South Korean patients with drug-susceptible tuberculosis.

UR - http://www.scopus.com/inward/record.url?scp=84866680220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866680220&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1843.2012.02218.x

DO - 10.1111/j.1440-1843.2012.02218.x

M3 - Article

C2 - 22758779

AN - SCOPUS:84866680220

VL - 17

SP - 1125

EP - 1130

JO - Respirology

JF - Respirology

SN - 1323-7799

IS - 7

ER -