Poor prediction of potentially drug-resistant pathogens using current criteria of health care-associated pneumonia

Seon Cheol Park, Young Ae Kang, Byung Hoon Park, Eun Young Kim, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Ji Ye Jung

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Abstract

Background: Health care-associated pneumonia (HCAP) includes a broad range of patients having frequent or chronic contact with health care systems. However, the relationship between current defining criteria for HCAP and the risk of potentially drug-resistant (PDR) pathogens is controversial. Methods: We retrospectively evaluated patients admitted to Severance Hospital in South Korea with culture-positive pneumonia from January 2008 to December 2009. We analyzed the associations between risk factors for HCAP and infection with PDR pathogens, and developed a new scoring system to predict infection with PDR pathogens. Results: Among 339 patients, PDR pathogens were observed in 122 (36.0%). PDR pathogens were more common in HCAP than community-acquired pneumonia (CAP) (48.5% versus 23.8%, P < 0.001). In a logistic regression, prior hospitalization within 90 days of pneumonia (OR = 2.51, P = 0.003), recent treatment with antimicrobials (OR = 2.35, P = 0.039), and nasogastric tube feeding (OR = 15.28, P < 0.001) were independently associated with PDR pathogens. For the prediction of PDR pathogens, the sensitivity and specificity of current HCAP criteria were 66.4% and 60.4%, respectively, and 68.0% and 67.3%, respectively, for the new scoring system. Moreover, the new scoring system showed better diagnostic accuracy than current HCAP criteria (area under curve = 0.711 versus 0.634, P < 0.001). Conclusions: The current HCAP criteria are poor predictors of PDR pathogens and all patients with HCAP should not be empirically treated for these pathogens. To avoid excessive antibiotic use, individual risk stratification approaches should be considered.

Original languageEnglish
Pages (from-to)1311-1319
Number of pages9
JournalRespiratory Medicine
Volume106
Issue number9
DOIs
Publication statusPublished - 2012 Sep 1

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Pneumonia
Delivery of Health Care
Pharmaceutical Preparations
Republic of Korea
Enteral Nutrition
Cross Infection
Area Under Curve
Hospitalization
Logistic Models
Anti-Bacterial Agents
Sensitivity and Specificity
Infection

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Park, Seon Cheol ; Kang, Young Ae ; Park, Byung Hoon ; Kim, Eun Young ; Park, Moo Suk ; Kim, Young Sam ; Kim, Se Kyu ; Chang, Joon ; Jung, Ji Ye. / Poor prediction of potentially drug-resistant pathogens using current criteria of health care-associated pneumonia. In: Respiratory Medicine. 2012 ; Vol. 106, No. 9. pp. 1311-1319.
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abstract = "Background: Health care-associated pneumonia (HCAP) includes a broad range of patients having frequent or chronic contact with health care systems. However, the relationship between current defining criteria for HCAP and the risk of potentially drug-resistant (PDR) pathogens is controversial. Methods: We retrospectively evaluated patients admitted to Severance Hospital in South Korea with culture-positive pneumonia from January 2008 to December 2009. We analyzed the associations between risk factors for HCAP and infection with PDR pathogens, and developed a new scoring system to predict infection with PDR pathogens. Results: Among 339 patients, PDR pathogens were observed in 122 (36.0{\%}). PDR pathogens were more common in HCAP than community-acquired pneumonia (CAP) (48.5{\%} versus 23.8{\%}, P < 0.001). In a logistic regression, prior hospitalization within 90 days of pneumonia (OR = 2.51, P = 0.003), recent treatment with antimicrobials (OR = 2.35, P = 0.039), and nasogastric tube feeding (OR = 15.28, P < 0.001) were independently associated with PDR pathogens. For the prediction of PDR pathogens, the sensitivity and specificity of current HCAP criteria were 66.4{\%} and 60.4{\%}, respectively, and 68.0{\%} and 67.3{\%}, respectively, for the new scoring system. Moreover, the new scoring system showed better diagnostic accuracy than current HCAP criteria (area under curve = 0.711 versus 0.634, P < 0.001). Conclusions: The current HCAP criteria are poor predictors of PDR pathogens and all patients with HCAP should not be empirically treated for these pathogens. To avoid excessive antibiotic use, individual risk stratification approaches should be considered.",
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Poor prediction of potentially drug-resistant pathogens using current criteria of health care-associated pneumonia. / Park, Seon Cheol; Kang, Young Ae; Park, Byung Hoon; Kim, Eun Young; Park, Moo Suk; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Jung, Ji Ye.

In: Respiratory Medicine, Vol. 106, No. 9, 01.09.2012, p. 1311-1319.

Research output: Contribution to journalArticle

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AU - Kang, Young Ae

AU - Park, Byung Hoon

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AU - Park, Moo Suk

AU - Kim, Young Sam

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Jung, Ji Ye

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N2 - Background: Health care-associated pneumonia (HCAP) includes a broad range of patients having frequent or chronic contact with health care systems. However, the relationship between current defining criteria for HCAP and the risk of potentially drug-resistant (PDR) pathogens is controversial. Methods: We retrospectively evaluated patients admitted to Severance Hospital in South Korea with culture-positive pneumonia from January 2008 to December 2009. We analyzed the associations between risk factors for HCAP and infection with PDR pathogens, and developed a new scoring system to predict infection with PDR pathogens. Results: Among 339 patients, PDR pathogens were observed in 122 (36.0%). PDR pathogens were more common in HCAP than community-acquired pneumonia (CAP) (48.5% versus 23.8%, P < 0.001). In a logistic regression, prior hospitalization within 90 days of pneumonia (OR = 2.51, P = 0.003), recent treatment with antimicrobials (OR = 2.35, P = 0.039), and nasogastric tube feeding (OR = 15.28, P < 0.001) were independently associated with PDR pathogens. For the prediction of PDR pathogens, the sensitivity and specificity of current HCAP criteria were 66.4% and 60.4%, respectively, and 68.0% and 67.3%, respectively, for the new scoring system. Moreover, the new scoring system showed better diagnostic accuracy than current HCAP criteria (area under curve = 0.711 versus 0.634, P < 0.001). Conclusions: The current HCAP criteria are poor predictors of PDR pathogens and all patients with HCAP should not be empirically treated for these pathogens. To avoid excessive antibiotic use, individual risk stratification approaches should be considered.

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