Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery

Yun Jeong Son, In Soo Yoon, Jong Hyuk Sung, Hyun Jong Cho, Suk Jae Chung, Chang Koo Shim, Dae Duk Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume61
DOIs
Publication statusPublished - 2013 Oct 1

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

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