Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery

Yun Jeong Son, In Soo Yoon, Jong Hyuk Sung, Hyun Jong Cho, Suk Jae Chung, Chang Koo Shim, Dae Duk Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The aim of this study is to evaluate the feasibility of hyaluronic acid/sodium alginate (HA/SA) scaffold-based interpenetrating polymeric network (IPN) for the proliferation and chondrogenic differentiation of the human adipose-derived stem cells (hADSCs). The hADSCs cultured in HA/SA IPN scaffold exhibited enhanced cell adhesion and proliferation compared to the HA scaffold. Superior chondrogenic differentiation of hADSCs in HA/SA IPN scaffold, compared to HA-based scaffold, was confirmed by measuring expression levels of chondrogenic markers. These results suggested that HA/SA IPN scaffold could provide a desirable environment for the cell adhesion, proliferation and chondrogenic differentiation of hADSCs.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume61
DOIs
Publication statusPublished - 2013 Oct 1

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Hyaluronic Acid
Stem cells
Scaffolds
Stem Cells
Scaffolds (biology)
Cell adhesion
Composite materials
Cell Adhesion
Cell Proliferation
Cell proliferation
alginic acid

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

Cite this

Son, Yun Jeong ; Yoon, In Soo ; Sung, Jong Hyuk ; Cho, Hyun Jong ; Chung, Suk Jae ; Shim, Chang Koo ; Kim, Dae Duk. / Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery. In: International Journal of Biological Macromolecules. 2013 ; Vol. 61. pp. 175-181.
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Porous hyaluronic acid/sodium alginate composite scaffolds for human adipose-derived stem cells delivery. / Son, Yun Jeong; Yoon, In Soo; Sung, Jong Hyuk; Cho, Hyun Jong; Chung, Suk Jae; Shim, Chang Koo; Kim, Dae Duk.

In: International Journal of Biological Macromolecules, Vol. 61, 01.10.2013, p. 175-181.

Research output: Contribution to journalArticle

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