Portal hypertensive gastropathy: Correlation with portal hypertension and prognosis in cirrhosis

Moon Young Kim, Hoon Choi, Soon Koo Baik, Chang Jin Yea, Chan Sik Won, Jong Won Byun, So Yeon Park, Yong Hwan Kwon, Jae Woo Kim, Hyun Soo Kim, Sang Ok Kwon, Young Ju Kim, Seung Hwan Cha, Sei Jin Chang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis. Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated. Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030). Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.

Original languageEnglish
Pages (from-to)3561-3567
Number of pages7
JournalDigestive diseases and sciences
Volume55
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Portal Hypertension
Fibrosis
Venous Pressure
Survival
Liver
End Stage Liver Disease
Kaplan-Meier Estimate
Liver Diseases
Regression Analysis
Confidence Intervals
Mortality

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Kim, Moon Young ; Choi, Hoon ; Baik, Soon Koo ; Yea, Chang Jin ; Won, Chan Sik ; Byun, Jong Won ; Park, So Yeon ; Kwon, Yong Hwan ; Kim, Jae Woo ; Kim, Hyun Soo ; Kwon, Sang Ok ; Kim, Young Ju ; Cha, Seung Hwan ; Chang, Sei Jin. / Portal hypertensive gastropathy : Correlation with portal hypertension and prognosis in cirrhosis. In: Digestive diseases and sciences. 2010 ; Vol. 55, No. 12. pp. 3561-3567.
@article{995e2a20ae724052aa6be9dd483e274e,
title = "Portal hypertensive gastropathy: Correlation with portal hypertension and prognosis in cirrhosis",
abstract = "Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis. Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8{\%}; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated. Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5{\%}) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95{\%} confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030). Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.",
author = "Kim, {Moon Young} and Hoon Choi and Baik, {Soon Koo} and Yea, {Chang Jin} and Won, {Chan Sik} and Byun, {Jong Won} and Park, {So Yeon} and Kwon, {Yong Hwan} and Kim, {Jae Woo} and Kim, {Hyun Soo} and Kwon, {Sang Ok} and Kim, {Young Ju} and Cha, {Seung Hwan} and Chang, {Sei Jin}",
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doi = "10.1007/s10620-010-1221-6",
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Kim, MY, Choi, H, Baik, SK, Yea, CJ, Won, CS, Byun, JW, Park, SY, Kwon, YH, Kim, JW, Kim, HS, Kwon, SO, Kim, YJ, Cha, SH & Chang, SJ 2010, 'Portal hypertensive gastropathy: Correlation with portal hypertension and prognosis in cirrhosis', Digestive diseases and sciences, vol. 55, no. 12, pp. 3561-3567. https://doi.org/10.1007/s10620-010-1221-6

Portal hypertensive gastropathy : Correlation with portal hypertension and prognosis in cirrhosis. / Kim, Moon Young; Choi, Hoon; Baik, Soon Koo; Yea, Chang Jin; Won, Chan Sik; Byun, Jong Won; Park, So Yeon; Kwon, Yong Hwan; Kim, Jae Woo; Kim, Hyun Soo; Kwon, Sang Ok; Kim, Young Ju; Cha, Seung Hwan; Chang, Sei Jin.

In: Digestive diseases and sciences, Vol. 55, No. 12, 01.12.2010, p. 3561-3567.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Portal hypertensive gastropathy

T2 - Correlation with portal hypertension and prognosis in cirrhosis

AU - Kim, Moon Young

AU - Choi, Hoon

AU - Baik, Soon Koo

AU - Yea, Chang Jin

AU - Won, Chan Sik

AU - Byun, Jong Won

AU - Park, So Yeon

AU - Kwon, Yong Hwan

AU - Kim, Jae Woo

AU - Kim, Hyun Soo

AU - Kwon, Sang Ok

AU - Kim, Young Ju

AU - Cha, Seung Hwan

AU - Chang, Sei Jin

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis. Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated. Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030). Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.

AB - Background: Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis. Methods: The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated. Results: The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030). Conclusions: PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.

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U2 - 10.1007/s10620-010-1221-6

DO - 10.1007/s10620-010-1221-6

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AN - SCOPUS:78649311188

VL - 55

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EP - 3567

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

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