Positive association between short-term ambient air pollution exposure and children blood pressure in China–Result from the Seven Northeast Cities (SNEC) study

Xiao Wen Zeng, Zhengmin (Min) Qian, Michael George Vaughn, Erik J. Nelson, Shyamali C. Dharmage, Gayan Bowatte, Jennifer Perret, Duo Hong Chen, Huimin Ma, Shao Lin, Benjamin de Foy, Li Wen Hu, Bo Yi Yang, Shu Li Xu, Chuan Zhang, Yan Peng Tian, Min Nian, Jia Wang, Xiang Xiao, Wen Wen Bao & 2 others Ya Zhi Zhang, Guang Hui Dong

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Abstract

The impact of ambient air pollution on health causes concerns in China. However, little is known about the association of short-term air pollution exposure with blood pressure (BP) in children. The goal of present study was to assess the association between short-term air pollution and BP in children from a highly polluted area in China. This study enrolled 9354 children in 24 elementary and middle schools (aged 5–17 years) from the Seven Northeast Cities (SNEC) study, respectively, during the period of 2012–2013. Ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2) and ozone (O3) on the days (1–5 days) preceding BP examination were collected from local air monitoring stations. Generalized additive models and two-level regression analyses were used to evaluate the relationship between air pollution and BP after adjusting for other covariates. Results showed that with an interquartile range (IQR) increase in PM10 (50.0 μg/m3) and O3 (53.0 μg/m3) level during the 5-day mean exposure, positive associations with elevated BP were observed, with an odds ratio of 2.17 (95% CI, 1.61–2.93) for PM10 and 2.77 (95% CI, 1.94–3.95) for O3. Both systolic BP and diastolic BP levels were positively associated with an IQR increase of four air pollutants at different lag times. Specifically, an IQR increase in the 5-day mean of PM10 and O3 was associated with elevation of 2.07 mmHg (95% CI, 1.71–2.44) and 3.29 mmHg (95% CI, 2.86–3.72) in systolic BP, respectively. When stratified by sex, positive relationships were observed for elevated BP with NO2 exposure only in males. This is the first report on the relationship between ambient short-term air pollution exposure and children BP in China. Findings indicate a need to control air pollutants and protect children from heavy air pollution exposure in China.

Original languageEnglish
Pages (from-to)698-705
Number of pages8
JournalEnvironmental Pollution
Volume224
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Blood pressure
Air Pollution
Air pollution
Blood Pressure
Air Pollutants
China
Air Pressure
Air
Nitrogen Dioxide
Sulfur Dioxide
Particulate Matter
Ozone
Sulfur dioxide
Aerodynamics
Health
Nitrogen
Monitoring
Odds Ratio
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Zeng, Xiao Wen ; Qian, Zhengmin (Min) ; Vaughn, Michael George ; Nelson, Erik J. ; Dharmage, Shyamali C. ; Bowatte, Gayan ; Perret, Jennifer ; Chen, Duo Hong ; Ma, Huimin ; Lin, Shao ; de Foy, Benjamin ; Hu, Li Wen ; Yang, Bo Yi ; Xu, Shu Li ; Zhang, Chuan ; Tian, Yan Peng ; Nian, Min ; Wang, Jia ; Xiao, Xiang ; Bao, Wen Wen ; Zhang, Ya Zhi ; Dong, Guang Hui. / Positive association between short-term ambient air pollution exposure and children blood pressure in China–Result from the Seven Northeast Cities (SNEC) study. In: Environmental Pollution. 2017 ; Vol. 224. pp. 698-705.
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abstract = "The impact of ambient air pollution on health causes concerns in China. However, little is known about the association of short-term air pollution exposure with blood pressure (BP) in children. The goal of present study was to assess the association between short-term air pollution and BP in children from a highly polluted area in China. This study enrolled 9354 children in 24 elementary and middle schools (aged 5–17 years) from the Seven Northeast Cities (SNEC) study, respectively, during the period of 2012–2013. Ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2) and ozone (O3) on the days (1–5 days) preceding BP examination were collected from local air monitoring stations. Generalized additive models and two-level regression analyses were used to evaluate the relationship between air pollution and BP after adjusting for other covariates. Results showed that with an interquartile range (IQR) increase in PM10 (50.0 μg/m3) and O3 (53.0 μg/m3) level during the 5-day mean exposure, positive associations with elevated BP were observed, with an odds ratio of 2.17 (95{\%} CI, 1.61–2.93) for PM10 and 2.77 (95{\%} CI, 1.94–3.95) for O3. Both systolic BP and diastolic BP levels were positively associated with an IQR increase of four air pollutants at different lag times. Specifically, an IQR increase in the 5-day mean of PM10 and O3 was associated with elevation of 2.07 mmHg (95{\%} CI, 1.71–2.44) and 3.29 mmHg (95{\%} CI, 2.86–3.72) in systolic BP, respectively. When stratified by sex, positive relationships were observed for elevated BP with NO2 exposure only in males. This is the first report on the relationship between ambient short-term air pollution exposure and children BP in China. Findings indicate a need to control air pollutants and protect children from heavy air pollution exposure in China.",
author = "Zeng, {Xiao Wen} and Qian, {Zhengmin (Min)} and Vaughn, {Michael George} and Nelson, {Erik J.} and Dharmage, {Shyamali C.} and Gayan Bowatte and Jennifer Perret and Chen, {Duo Hong} and Huimin Ma and Shao Lin and {de Foy}, Benjamin and Hu, {Li Wen} and Yang, {Bo Yi} and Xu, {Shu Li} and Chuan Zhang and Tian, {Yan Peng} and Min Nian and Jia Wang and Xiang Xiao and Bao, {Wen Wen} and Zhang, {Ya Zhi} and Dong, {Guang Hui}",
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Zeng, XW, Qian, ZM, Vaughn, MG, Nelson, EJ, Dharmage, SC, Bowatte, G, Perret, J, Chen, DH, Ma, H, Lin, S, de Foy, B, Hu, LW, Yang, BY, Xu, SL, Zhang, C, Tian, YP, Nian, M, Wang, J, Xiao, X, Bao, WW, Zhang, YZ & Dong, GH 2017, 'Positive association between short-term ambient air pollution exposure and children blood pressure in China–Result from the Seven Northeast Cities (SNEC) study', Environmental Pollution, vol. 224, pp. 698-705. https://doi.org/10.1016/j.envpol.2017.02.054

Positive association between short-term ambient air pollution exposure and children blood pressure in China–Result from the Seven Northeast Cities (SNEC) study. / Zeng, Xiao Wen; Qian, Zhengmin (Min); Vaughn, Michael George; Nelson, Erik J.; Dharmage, Shyamali C.; Bowatte, Gayan; Perret, Jennifer; Chen, Duo Hong; Ma, Huimin; Lin, Shao; de Foy, Benjamin; Hu, Li Wen; Yang, Bo Yi; Xu, Shu Li; Zhang, Chuan; Tian, Yan Peng; Nian, Min; Wang, Jia; Xiao, Xiang; Bao, Wen Wen; Zhang, Ya Zhi; Dong, Guang Hui.

In: Environmental Pollution, Vol. 224, 01.01.2017, p. 698-705.

Research output: Contribution to journalArticle

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T1 - Positive association between short-term ambient air pollution exposure and children blood pressure in China–Result from the Seven Northeast Cities (SNEC) study

AU - Zeng, Xiao Wen

AU - Qian, Zhengmin (Min)

AU - Vaughn, Michael George

AU - Nelson, Erik J.

AU - Dharmage, Shyamali C.

AU - Bowatte, Gayan

AU - Perret, Jennifer

AU - Chen, Duo Hong

AU - Ma, Huimin

AU - Lin, Shao

AU - de Foy, Benjamin

AU - Hu, Li Wen

AU - Yang, Bo Yi

AU - Xu, Shu Li

AU - Zhang, Chuan

AU - Tian, Yan Peng

AU - Nian, Min

AU - Wang, Jia

AU - Xiao, Xiang

AU - Bao, Wen Wen

AU - Zhang, Ya Zhi

AU - Dong, Guang Hui

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The impact of ambient air pollution on health causes concerns in China. However, little is known about the association of short-term air pollution exposure with blood pressure (BP) in children. The goal of present study was to assess the association between short-term air pollution and BP in children from a highly polluted area in China. This study enrolled 9354 children in 24 elementary and middle schools (aged 5–17 years) from the Seven Northeast Cities (SNEC) study, respectively, during the period of 2012–2013. Ambient air pollutants, including particulate matter with an aerodynamic diameter of ≤10 μm (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2) and ozone (O3) on the days (1–5 days) preceding BP examination were collected from local air monitoring stations. Generalized additive models and two-level regression analyses were used to evaluate the relationship between air pollution and BP after adjusting for other covariates. Results showed that with an interquartile range (IQR) increase in PM10 (50.0 μg/m3) and O3 (53.0 μg/m3) level during the 5-day mean exposure, positive associations with elevated BP were observed, with an odds ratio of 2.17 (95% CI, 1.61–2.93) for PM10 and 2.77 (95% CI, 1.94–3.95) for O3. Both systolic BP and diastolic BP levels were positively associated with an IQR increase of four air pollutants at different lag times. Specifically, an IQR increase in the 5-day mean of PM10 and O3 was associated with elevation of 2.07 mmHg (95% CI, 1.71–2.44) and 3.29 mmHg (95% CI, 2.86–3.72) in systolic BP, respectively. When stratified by sex, positive relationships were observed for elevated BP with NO2 exposure only in males. This is the first report on the relationship between ambient short-term air pollution exposure and children BP in China. Findings indicate a need to control air pollutants and protect children from heavy air pollution exposure in China.

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