Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan

Xiao Di Qin, Zhengmin Qian, Michael G. Vaughn, Jin Huang, Patrick Ward, Xiao Wen Zeng, Yang Zhou, Yu Zhu, Ping Yuan, Meng Li, Zhipeng Bai, Gunther Paul, Yuan Tao Hao, Wen Chen, Pau Chung Chen, Guang Hui Dong, Yungling Leo Lee

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26 Citations (Scopus)


To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalEnvironmental Pollution
Publication statusPublished - 2016 May 1

Bibliographical note

Funding Information:
The authors acknowledge the cooperation of the seven cities, school principals, teachers, and students and their parents. This study was supported by Grants no. 98-2314-B-002-138-MY3 and no. 101-2621-M-002-005 from the National Science Council in Taiwan , Grants no. 81172630 and no. 81472936 from the National Natural Science Foundation of China , and Grant no. 2014A030313021 from Guangdong Province Natural Science Foundation . The authors report no competing financial interest.

Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis


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