Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan

Xiao Di Qin, Zhengmin Qian, Michael G. Vaughn, Jin Huang, Patrick Ward, Xiao Wen Zeng, Yang Zhou, Yu Zhu, Ping Yuan, Meng Li, Zhipeng Bai, Gunther Paul, Yuan Tao Hao, Wen Chen, Pau Chung Chen, Guang Hui Dong, Yungling Leo Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalEnvironmental Pollution
Volume212
DOIs
Publication statusPublished - 2016 May 1

Fingerprint

Hyperuricemia
Uric Acid
Taiwan
Acids
Linear Models
Serum
Logistic Models
Linear regression
Logistics
Research

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Qin, Xiao Di ; Qian, Zhengmin ; Vaughn, Michael G. ; Huang, Jin ; Ward, Patrick ; Zeng, Xiao Wen ; Zhou, Yang ; Zhu, Yu ; Yuan, Ping ; Li, Meng ; Bai, Zhipeng ; Paul, Gunther ; Hao, Yuan Tao ; Chen, Wen ; Chen, Pau Chung ; Dong, Guang Hui ; Lee, Yungling Leo. / Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. In: Environmental Pollution. 2016 ; Vol. 212. pp. 519-524.
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title = "Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan",
abstract = "To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94{\%} of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95{\%}CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95{\%}CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.",
author = "Qin, {Xiao Di} and Zhengmin Qian and Vaughn, {Michael G.} and Jin Huang and Patrick Ward and Zeng, {Xiao Wen} and Yang Zhou and Yu Zhu and Ping Yuan and Meng Li and Zhipeng Bai and Gunther Paul and Hao, {Yuan Tao} and Wen Chen and Chen, {Pau Chung} and Dong, {Guang Hui} and Lee, {Yungling Leo}",
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Qin, XD, Qian, Z, Vaughn, MG, Huang, J, Ward, P, Zeng, XW, Zhou, Y, Zhu, Y, Yuan, P, Li, M, Bai, Z, Paul, G, Hao, YT, Chen, W, Chen, PC, Dong, GH & Lee, YL 2016, 'Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan', Environmental Pollution, vol. 212, pp. 519-524. https://doi.org/10.1016/j.envpol.2016.02.050

Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. / Qin, Xiao Di; Qian, Zhengmin; Vaughn, Michael G.; Huang, Jin; Ward, Patrick; Zeng, Xiao Wen; Zhou, Yang; Zhu, Yu; Yuan, Ping; Li, Meng; Bai, Zhipeng; Paul, Gunther; Hao, Yuan Tao; Chen, Wen; Chen, Pau Chung; Dong, Guang Hui; Lee, Yungling Leo.

In: Environmental Pollution, Vol. 212, 01.05.2016, p. 519-524.

Research output: Contribution to journalArticle

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AU - Qin, Xiao Di

AU - Qian, Zhengmin

AU - Vaughn, Michael G.

AU - Huang, Jin

AU - Ward, Patrick

AU - Zeng, Xiao Wen

AU - Zhou, Yang

AU - Zhu, Yu

AU - Yuan, Ping

AU - Li, Meng

AU - Bai, Zhipeng

AU - Paul, Gunther

AU - Hao, Yuan Tao

AU - Chen, Wen

AU - Chen, Pau Chung

AU - Dong, Guang Hui

AU - Lee, Yungling Leo

PY - 2016/5/1

Y1 - 2016/5/1

N2 - To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.

AB - To investigate the risk of hyperuricemia in relation to Perfluoroalkyl substances (PFASs) in children from Taiwan, 225 Taiwanese children aged 12-15 years were recruited from 2009 to 2010. Linear and logistic regression models were employed to examine the influence of PFASs on serum uric acid levels. Findings revealed that eight of ten PFASs analyses were detected in >94% of the participants' serum samples. Multivariate linear regression models revealed that perfluorooctanic acid (PFOA) was positively associated with serum uric acid levels (β = 0.1463, p < 0.05). Of all the PFASs analyses, only PFOA showed a significant effect on elevated levels of hyperuricemia (aOR = 2.16, 95%CI: 1.29-3.61). When stratified by gender, the association between serum PFOA and uric acid levels was only evident among boys (aOR = 2.76, 95%CI: 1.37-5.56). In conclusion, PFOA was found to be associated with elevated serum levels of uric acid in Taiwanese children, especially boys. Further research is needed to elucidate these links.

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