Positive effects of hydrogen water on 2, 4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Yang Suk Yoon, Ma Easter Joy Villarosa Sajo, Rosa Mistica Coles Ignacio, Soo Ki Kim, Cheol Su Kim, Kyu Jae Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we investigated the effect of drinking hydrogen water (HW) on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical symptoms. In line with this, the level of reactive oxygen species in the HW group was significantly inhibited compared with that in the purified water (PW) group. In parallel, HW enhanced glutathione peroxidase activity in DNCB-induced AD as compared with the PW group. Accordingly, the levels of thymus and activation-regulated chemokine and cytokines were significantly decreased in the HW group compared with the PW group. Notably, the levels of Th2cytokine, interleukin-5 (IL-5), and proinflammatory cytokines such as tumor necrosis factor-α and IL-6 in HW-fed mice were significantly lower than in control and PW-fed mice. The total serum immunoglobulin E level was also markedly reduced in the HW group. The collective results indicate that HW suppresses DNCB-induced AD in NC/Nga mice via redox balance and immune modulation and could be a safe clinical fluid treatment for AD.

Original languageEnglish
Pages (from-to)1480-1485
Number of pages6
JournalBiological and Pharmaceutical Bulletin
Volume37
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Dinitrochlorobenzene
Atopic Dermatitis
Hydrogen
Water
Eczematous Skin Diseases
Chemokine CCL17
Cytokines
Interleukin-5
Glutathione Peroxidase
Drinking Water
Immunoglobulin E
Oxidation-Reduction
Interleukin-6
Reactive Oxygen Species
Oxidative Stress
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Yoon, Yang Suk ; Sajo, Ma Easter Joy Villarosa ; Ignacio, Rosa Mistica Coles ; Kim, Soo Ki ; Kim, Cheol Su ; Lee, Kyu Jae. / Positive effects of hydrogen water on 2, 4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. In: Biological and Pharmaceutical Bulletin. 2014 ; Vol. 37, No. 9. pp. 1480-1485.
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abstract = "Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we investigated the effect of drinking hydrogen water (HW) on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical symptoms. In line with this, the level of reactive oxygen species in the HW group was significantly inhibited compared with that in the purified water (PW) group. In parallel, HW enhanced glutathione peroxidase activity in DNCB-induced AD as compared with the PW group. Accordingly, the levels of thymus and activation-regulated chemokine and cytokines were significantly decreased in the HW group compared with the PW group. Notably, the levels of Th2cytokine, interleukin-5 (IL-5), and proinflammatory cytokines such as tumor necrosis factor-α and IL-6 in HW-fed mice were significantly lower than in control and PW-fed mice. The total serum immunoglobulin E level was also markedly reduced in the HW group. The collective results indicate that HW suppresses DNCB-induced AD in NC/Nga mice via redox balance and immune modulation and could be a safe clinical fluid treatment for AD.",
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Positive effects of hydrogen water on 2, 4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. / Yoon, Yang Suk; Sajo, Ma Easter Joy Villarosa; Ignacio, Rosa Mistica Coles; Kim, Soo Ki; Kim, Cheol Su; Lee, Kyu Jae.

In: Biological and Pharmaceutical Bulletin, Vol. 37, No. 9, 2014, p. 1480-1485.

Research output: Contribution to journalArticle

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AU - Yoon, Yang Suk

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AU - Kim, Soo Ki

AU - Kim, Cheol Su

AU - Lee, Kyu Jae

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AB - Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we investigated the effect of drinking hydrogen water (HW) on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical symptoms. In line with this, the level of reactive oxygen species in the HW group was significantly inhibited compared with that in the purified water (PW) group. In parallel, HW enhanced glutathione peroxidase activity in DNCB-induced AD as compared with the PW group. Accordingly, the levels of thymus and activation-regulated chemokine and cytokines were significantly decreased in the HW group compared with the PW group. Notably, the levels of Th2cytokine, interleukin-5 (IL-5), and proinflammatory cytokines such as tumor necrosis factor-α and IL-6 in HW-fed mice were significantly lower than in control and PW-fed mice. The total serum immunoglobulin E level was also markedly reduced in the HW group. The collective results indicate that HW suppresses DNCB-induced AD in NC/Nga mice via redox balance and immune modulation and could be a safe clinical fluid treatment for AD.

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