Positive predictability and predictive factors of the third generation anti-hepatitis C virus (HCV) ELISA test for HCV infection

Young Ki Kim, Byung Ho Kim, Eun Seon Jin, Ki Deuk Nam, Jae Young Jang, Nam Hoon Kim, Sang Kil Lee, Kwang Ro Joo, Seok Ho Dong, Hyo Jong Kim, Young Woon Chang, Joung Il Lee, Rin Chang

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Abstract

BACKGROUND/AIMS: Anti-HCV positivity suggests past or present infection of HCV, or false positivity. The positive predictability of this test can differ according to the subjects. This study examines the positive predictability of the third generation anti-HCV ELISA and factors predicting HCV infection with special emphasis on the significance of the anti-HCV sample/cut-off (S/CO) ratio. METHODS: One hundred and ninety patients who were anti-HCV positive were enrolled, from November 1998 to January 2002 in Kyung Hee University Hospital. RT-PCR was performed to confirm HCV infection. RESULTS: One hundred and seven patients were RT-PCR positive (56.3% positive predictability). The positive predictability changed with the S/CO ratio: 17.9% in cases below 6, 58.3% between 6 and 50, 78.6% between 51 and 75, and 60% over 75. Those with the S/CO ratio more than 6 showed significantly higher predictability, but it did not increase further when the ratio got higher. Factors predicting HCV infection were the presence of liver cirrhosis (OR 5.5, p=0.000), hepatocellular carcinoma (OR 11.67, p=0.004), liver diseases (OR 2.99 p=0.001), and increase of AST (OR 2.49, p=0.002), ALT (OR 2.32, p=0.005), alpha-FP (OR 3.49, p=0.040), and the S/CO ratio of more than 6 (OR 7.82, p=0.000). However, liver cirrhosis was the sole factor in multivariate analysis (OR 8.32, p=0.02). CONCLUSIONS: The positive predictability of the third generation anti-HCV test was 56.3% with a significant difference between those with the S/CO ratio below 6 (18%) and above 6 (63%). In liver cirrhosis, positive predictability of anti-HCV test was relatively high as 85%.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume45
Issue number3
Publication statusPublished - 2005 Mar

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Kim, Y. K., Kim, B. H., Jin, E. S., Nam, K. D., Jang, J. Y., Kim, N. H., Lee, S. K., Joo, K. R., Dong, S. H., Kim, H. J., Chang, Y. W., Lee, J. I., & Chang, R. (2005). Positive predictability and predictive factors of the third generation anti-hepatitis C virus (HCV) ELISA test for HCV infection. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 45(3), 181-188.