Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients

A pilot study

Jin Young Park, Hae Jeong Park, Dae Jin Kim, Jae-Jin Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The development of diffusion tensor imaging (DTI) has provided information about microstructural changes in the brain. Most DTI studies have focused on white matter (WM). Few DTI studies have examined the gray matter (GM) in schizophrenia and, to date, there has been no attempt to identify the relationship between water diffusivity and symptom severity in schizophrenia. The present study aimed to examine microstructural deficits in the dorsal prefrontal cortex (DPFC) and temporal cortex in schizophrenia patients using fractional anisotropy (FA) and water diffusivity. This study also explored the relationship between DTI measurements and psychotic symptoms. Magnetic resonance imaging (MRI) and DTI were used to study 19 schizophrenia patients and 19 healthy controls. Fractional anisotropy, axial diffusivity, radial diffusivity, and regional volumes were measured in the prefrontal cortex and temporal cortex. On DTI measurements, patients showed increased axial and radial diffusivities in the prefrontal cortex and temporal cortex, but they did not demonstrate any difference in fractional anisotropy and regional volumes. Additionally, axial and radial diffusivities were significantly correlated with positive symptom scores in all regions of interest. These results indicate that water diffusivity measurements, including axial and radial diffusivities, can be used to identify microstructural changes in the gray matter in schizophrenia that may be related to symptom severity.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume224
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Diffusion Tensor Imaging
Temporal Lobe
Prefrontal Cortex
Schizophrenia
Water
Anisotropy
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

@article{797406e0653641f3ae9ce39ff5b2bb9d,
title = "Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients: A pilot study",
abstract = "The development of diffusion tensor imaging (DTI) has provided information about microstructural changes in the brain. Most DTI studies have focused on white matter (WM). Few DTI studies have examined the gray matter (GM) in schizophrenia and, to date, there has been no attempt to identify the relationship between water diffusivity and symptom severity in schizophrenia. The present study aimed to examine microstructural deficits in the dorsal prefrontal cortex (DPFC) and temporal cortex in schizophrenia patients using fractional anisotropy (FA) and water diffusivity. This study also explored the relationship between DTI measurements and psychotic symptoms. Magnetic resonance imaging (MRI) and DTI were used to study 19 schizophrenia patients and 19 healthy controls. Fractional anisotropy, axial diffusivity, radial diffusivity, and regional volumes were measured in the prefrontal cortex and temporal cortex. On DTI measurements, patients showed increased axial and radial diffusivities in the prefrontal cortex and temporal cortex, but they did not demonstrate any difference in fractional anisotropy and regional volumes. Additionally, axial and radial diffusivities were significantly correlated with positive symptom scores in all regions of interest. These results indicate that water diffusivity measurements, including axial and radial diffusivities, can be used to identify microstructural changes in the gray matter in schizophrenia that may be related to symptom severity.",
author = "Park, {Jin Young} and Park, {Hae Jeong} and Kim, {Dae Jin} and Jae-Jin Kim",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.pscychresns.2014.07.003",
language = "English",
volume = "224",
pages = "49--57",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients : A pilot study. / Park, Jin Young; Park, Hae Jeong; Kim, Dae Jin; Kim, Jae-Jin.

In: Psychiatry Research - Neuroimaging, Vol. 224, No. 1, 01.01.2014, p. 49-57.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Positive symptoms and water diffusivity of the prefrontal and temporal cortices in schizophrenia patients

T2 - A pilot study

AU - Park, Jin Young

AU - Park, Hae Jeong

AU - Kim, Dae Jin

AU - Kim, Jae-Jin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The development of diffusion tensor imaging (DTI) has provided information about microstructural changes in the brain. Most DTI studies have focused on white matter (WM). Few DTI studies have examined the gray matter (GM) in schizophrenia and, to date, there has been no attempt to identify the relationship between water diffusivity and symptom severity in schizophrenia. The present study aimed to examine microstructural deficits in the dorsal prefrontal cortex (DPFC) and temporal cortex in schizophrenia patients using fractional anisotropy (FA) and water diffusivity. This study also explored the relationship between DTI measurements and psychotic symptoms. Magnetic resonance imaging (MRI) and DTI were used to study 19 schizophrenia patients and 19 healthy controls. Fractional anisotropy, axial diffusivity, radial diffusivity, and regional volumes were measured in the prefrontal cortex and temporal cortex. On DTI measurements, patients showed increased axial and radial diffusivities in the prefrontal cortex and temporal cortex, but they did not demonstrate any difference in fractional anisotropy and regional volumes. Additionally, axial and radial diffusivities were significantly correlated with positive symptom scores in all regions of interest. These results indicate that water diffusivity measurements, including axial and radial diffusivities, can be used to identify microstructural changes in the gray matter in schizophrenia that may be related to symptom severity.

AB - The development of diffusion tensor imaging (DTI) has provided information about microstructural changes in the brain. Most DTI studies have focused on white matter (WM). Few DTI studies have examined the gray matter (GM) in schizophrenia and, to date, there has been no attempt to identify the relationship between water diffusivity and symptom severity in schizophrenia. The present study aimed to examine microstructural deficits in the dorsal prefrontal cortex (DPFC) and temporal cortex in schizophrenia patients using fractional anisotropy (FA) and water diffusivity. This study also explored the relationship between DTI measurements and psychotic symptoms. Magnetic resonance imaging (MRI) and DTI were used to study 19 schizophrenia patients and 19 healthy controls. Fractional anisotropy, axial diffusivity, radial diffusivity, and regional volumes were measured in the prefrontal cortex and temporal cortex. On DTI measurements, patients showed increased axial and radial diffusivities in the prefrontal cortex and temporal cortex, but they did not demonstrate any difference in fractional anisotropy and regional volumes. Additionally, axial and radial diffusivities were significantly correlated with positive symptom scores in all regions of interest. These results indicate that water diffusivity measurements, including axial and radial diffusivities, can be used to identify microstructural changes in the gray matter in schizophrenia that may be related to symptom severity.

UR - http://www.scopus.com/inward/record.url?scp=84921635448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921635448&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2014.07.003

DO - 10.1016/j.pscychresns.2014.07.003

M3 - Article

VL - 224

SP - 49

EP - 57

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 1

ER -