Post-translational regulation of miRNA pathway components, AGO1 and HYL1, in plants

Seok Keun Cho, Moon Young Ryu, Pratik Shah, Christian Peter Poulsen, Seong Wook Yang

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Post-translational modifications (PTMs) of proteins are essential to increase the functional diversity of the proteome. By adding chemical groups to proteins, or degrading entire proteins by phosphorylation, glycosylation, ubiquitination, neddylation, acetylation, lipidation, and proteolysis, the complexity of the proteome increases, and this then influences most biological processes. Although small RNAs are crucial regulatory elements for gene expression in most eukaryotes, PTMs of small RNA microprocessor and RNA silencing components have not been extensively investigated in plants. To date, several studies have shown that the proteolytic regulation of AGOs is important for host-pathogen interactions. DRB4 is regulated by the ubiquitin-proteasome system, and the degradation of HYL1 is modulated by a de-etiolation repressor, COP1, and an unknown cytoplasmic protease. Here, we discuss current findings on the PTMs of microprocessor and RNA silencing components in plants.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalMolecules and Cells
Volume39
Issue number8
DOIs
Publication statusPublished - 2016 Aug 1

Fingerprint

Post Translational Protein Processing
MicroRNAs
Microcomputers
Proteome
RNA Interference
Etiolation
RNA
Biological Phenomena
Host-Pathogen Interactions
Plant Structures
Ubiquitination
Proteasome Endopeptidase Complex
Regulator Genes
Acetylation
Ubiquitin
Eukaryota
Glycosylation
Proteolysis
Peptide Hydrolases
Phosphorylation

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Cho, Seok Keun ; Ryu, Moon Young ; Shah, Pratik ; Poulsen, Christian Peter ; Yang, Seong Wook. / Post-translational regulation of miRNA pathway components, AGO1 and HYL1, in plants. In: Molecules and Cells. 2016 ; Vol. 39, No. 8. pp. 581-586.
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Post-translational regulation of miRNA pathway components, AGO1 and HYL1, in plants. / Cho, Seok Keun; Ryu, Moon Young; Shah, Pratik; Poulsen, Christian Peter; Yang, Seong Wook.

In: Molecules and Cells, Vol. 39, No. 8, 01.08.2016, p. 581-586.

Research output: Contribution to journalReview article

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