Abstract
Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9 versus 62.8 ± 9.0, respectively; p=0.001) or the NC group (61.9 ± 9.9, p=0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.
| Original language | English |
|---|---|
| Pages (from-to) | 1237-1243 |
| Number of pages | 7 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 52 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
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Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease. / Ye, Byoung Seok; Lee, Yoonju; Kwak, Kichang; Park, Yeong Hun; Ham, Jee Hyun; Lee, Jae Jung; Shin, Na Young; Lee, Jong Min; Sohn, Young H.; Lee, philhyu.
In: Journal of Alzheimer's Disease, Vol. 52, No. 4, 01.01.2016, p. 1237-1243.Research output: Contribution to journal › Article
TY - JOUR
T1 - Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease
AU - Ye, Byoung Seok
AU - Lee, Yoonju
AU - Kwak, Kichang
AU - Park, Yeong Hun
AU - Ham, Jee Hyun
AU - Lee, Jae Jung
AU - Shin, Na Young
AU - Lee, Jong Min
AU - Sohn, Young H.
AU - Lee, philhyu
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9 versus 62.8 ± 9.0, respectively; p=0.001) or the NC group (61.9 ± 9.9, p=0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.
AB - Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9 versus 62.8 ± 9.0, respectively; p=0.001) or the NC group (61.9 ± 9.9, p=0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.
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UR - http://www.scopus.com/inward/citedby.url?scp=84974588559&partnerID=8YFLogxK
U2 - 10.3233/JAD-160062
DO - 10.3233/JAD-160062
M3 - Article
C2 - 27104902
AN - SCOPUS:84974588559
VL - 52
SP - 1237
EP - 1243
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 4
ER -