Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease

Byoung Seok Ye, Yoonju Lee, Kichang Kwak, Yeong Hun Park, Jee Hyun Ham, Jae Jung Lee, Na Young Shin, Jong Min Lee, Young H. Sohn, philhyu Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9 versus 62.8 ± 9.0, respectively; p=0.001) or the NC group (61.9 ± 9.9, p=0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.

Original languageEnglish
Pages (from-to)1237-1243
Number of pages7
JournalJournal of Alzheimer's Disease
Volume52
Issue number4
DOIs
Publication statusPublished - 2016 Jan 1

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Lewy Body Disease
Dementia
Alzheimer Disease
Cognition
Sex Education
Temporal Lobe
Lewy Bodies
Neuropsychological Tests
Lateral Ventricles
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Ye, Byoung Seok ; Lee, Yoonju ; Kwak, Kichang ; Park, Yeong Hun ; Ham, Jee Hyun ; Lee, Jae Jung ; Shin, Na Young ; Lee, Jong Min ; Sohn, Young H. ; Lee, philhyu. / Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease. In: Journal of Alzheimer's Disease. 2016 ; Vol. 52, No. 4. pp. 1237-1243.
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abstract = "Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9 versus 62.8 ± 9.0, respectively; p=0.001) or the NC group (61.9 ± 9.9, p=0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.",
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Ye, BS, Lee, Y, Kwak, K, Park, YH, Ham, JH, Lee, JJ, Shin, NY, Lee, JM, Sohn, YH & Lee, P 2016, 'Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease', Journal of Alzheimer's Disease, vol. 52, no. 4, pp. 1237-1243. https://doi.org/10.3233/JAD-160062

Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease. / Ye, Byoung Seok; Lee, Yoonju; Kwak, Kichang; Park, Yeong Hun; Ham, Jee Hyun; Lee, Jae Jung; Shin, Na Young; Lee, Jong Min; Sohn, Young H.; Lee, philhyu.

In: Journal of Alzheimer's Disease, Vol. 52, No. 4, 01.01.2016, p. 1237-1243.

Research output: Contribution to journalArticle

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AU - Lee, Yoonju

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AU - Lee, Jae Jung

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AU - Sohn, Young H.

AU - Lee, philhyu

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N2 - Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9 versus 62.8 ± 9.0, respectively; p=0.001) or the NC group (61.9 ± 9.9, p=0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.

AB - Background: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Objective: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. Methods: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. Results: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9 versus 62.8 ± 9.0, respectively; p=0.001) or the NC group (61.9 ± 9.9, p=0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. Conclusion: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.

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