Abstract
Background and Aims: The effects of chemotherapeutic agents on the development of colorectal adenomas in patients with previous colorectal cancer (CRC) are not defined. Therefore, we evaluated the potential effect of adjuvant chemotherapy on the incidence of colorectal adenomas in patients with previous CRC. Methods: We selected patients with low-risk stage II CRC with or without postoperative 5-fluorouracil–based adjuvant chemotherapy to reduce selection bias. Among 1808 patients with stage II CRC who underwent colonoscopic surveillance after curative resection of CRC between 2006 and 2013, 192 patients were retrospectively enrolled in this study after matching for age and sex. The patients were divided into 96 patients receiving and 96 patients not receiving 5-fluorouracil–based chemotherapy. Results: Forty patients (41.7%) exhibited colorectal adenomas among 96 patients who received adjuvant chemotherapy, compared with 50 patients (52.1%) with colorectal adenomas among 96 patients who received surgery only. The incidence rate of advanced adenoma was significantly lower in the chemotherapy group than in the nonchemotherapy group (3.1% vs 10.4%, P =.044). After adjustment for clinically relevant factors such as body mass index, aspirin use, metformin use, number of follow-up colonoscopies, and operation type, adjuvant chemotherapy was found to be associated with a decreased incidence of advanced adenoma (odds ratio,.151; 95% confidence interval,.035-.653; P =.011) in patients with stage II CRC. Conclusions: The results showed that chemotherapy in patients with CRC may be associated with a lower risk of colorectal advanced adenoma development.
| Original language | English |
|---|---|
| Pages (from-to) | 688-694.e2 |
| Journal | Gastrointestinal Endoscopy |
| Volume | 87 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2018 Mar |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Gastroenterology
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Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer. / Lee, Hee Seung; Kim, Sung Bae; Lee, Hyun Jung; Park, Soo Jung; Hong, Sung Pil; Cheon, Jae Hee; Kim, Won Ho; Kim, Tae Il.
In: Gastrointestinal Endoscopy, Vol. 87, No. 3, 03.2018, p. 688-694.e2.Research output: Contribution to journal › Article
TY - JOUR
T1 - Postoperative adjuvant chemotherapy is associated with a lower incidence of colorectal adenomas in patients with previous colorectal cancer
AU - Lee, Hee Seung
AU - Kim, Sung Bae
AU - Lee, Hyun Jung
AU - Park, Soo Jung
AU - Hong, Sung Pil
AU - Cheon, Jae Hee
AU - Kim, Won Ho
AU - Kim, Tae Il
PY - 2018/3
Y1 - 2018/3
N2 - Background and Aims: The effects of chemotherapeutic agents on the development of colorectal adenomas in patients with previous colorectal cancer (CRC) are not defined. Therefore, we evaluated the potential effect of adjuvant chemotherapy on the incidence of colorectal adenomas in patients with previous CRC. Methods: We selected patients with low-risk stage II CRC with or without postoperative 5-fluorouracil–based adjuvant chemotherapy to reduce selection bias. Among 1808 patients with stage II CRC who underwent colonoscopic surveillance after curative resection of CRC between 2006 and 2013, 192 patients were retrospectively enrolled in this study after matching for age and sex. The patients were divided into 96 patients receiving and 96 patients not receiving 5-fluorouracil–based chemotherapy. Results: Forty patients (41.7%) exhibited colorectal adenomas among 96 patients who received adjuvant chemotherapy, compared with 50 patients (52.1%) with colorectal adenomas among 96 patients who received surgery only. The incidence rate of advanced adenoma was significantly lower in the chemotherapy group than in the nonchemotherapy group (3.1% vs 10.4%, P =.044). After adjustment for clinically relevant factors such as body mass index, aspirin use, metformin use, number of follow-up colonoscopies, and operation type, adjuvant chemotherapy was found to be associated with a decreased incidence of advanced adenoma (odds ratio,.151; 95% confidence interval,.035-.653; P =.011) in patients with stage II CRC. Conclusions: The results showed that chemotherapy in patients with CRC may be associated with a lower risk of colorectal advanced adenoma development.
AB - Background and Aims: The effects of chemotherapeutic agents on the development of colorectal adenomas in patients with previous colorectal cancer (CRC) are not defined. Therefore, we evaluated the potential effect of adjuvant chemotherapy on the incidence of colorectal adenomas in patients with previous CRC. Methods: We selected patients with low-risk stage II CRC with or without postoperative 5-fluorouracil–based adjuvant chemotherapy to reduce selection bias. Among 1808 patients with stage II CRC who underwent colonoscopic surveillance after curative resection of CRC between 2006 and 2013, 192 patients were retrospectively enrolled in this study after matching for age and sex. The patients were divided into 96 patients receiving and 96 patients not receiving 5-fluorouracil–based chemotherapy. Results: Forty patients (41.7%) exhibited colorectal adenomas among 96 patients who received adjuvant chemotherapy, compared with 50 patients (52.1%) with colorectal adenomas among 96 patients who received surgery only. The incidence rate of advanced adenoma was significantly lower in the chemotherapy group than in the nonchemotherapy group (3.1% vs 10.4%, P =.044). After adjustment for clinically relevant factors such as body mass index, aspirin use, metformin use, number of follow-up colonoscopies, and operation type, adjuvant chemotherapy was found to be associated with a decreased incidence of advanced adenoma (odds ratio,.151; 95% confidence interval,.035-.653; P =.011) in patients with stage II CRC. Conclusions: The results showed that chemotherapy in patients with CRC may be associated with a lower risk of colorectal advanced adenoma development.
UR - http://www.scopus.com/inward/record.url?scp=85019718974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019718974&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2017.04.004
DO - 10.1016/j.gie.2017.04.004
M3 - Article
C2 - 28431950
AN - SCOPUS:85019718974
VL - 87
SP - 688-694.e2
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 3
ER -