Postoperative biochemical recurrence of pathologically localized high-grade prostate cancer in adjuvant treatment-naïve patients

Ji Eun Heo, Jee Soo Park, Jong Soo Lee, Jongchan Kim, Won Sik Jang, Nam Hoon Cho, Koon Ho Rha, Young Deuk Choi, Sung Joon Hong, Won Sik Ham

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate biochemical recurrence (BCR) risk in men with localized prostate cancer (PC) of pathological Gleason score (pGS) 8–10. Although such patients have low BCR-free survival (BCRFS) following radical prostatectomy (RP), they are not recommended for adjuvant radiation therapy (ART) as per current guidelines. Methods: Among an adjuvant treatment-naïve cohort between 1995 and 2015, 1272 men were identified and categorized into group 1 [pGS7 (3 + 4) and pT3; n = 654], group 2 [pGS7 (4 + 3) and pT3; n = 408], and group 3 (pGS 8–10 and pT2; n = 210). The BCR risk of group 3 was compared with that of groups 1 and 2 who are the candidates for ART. Results: At a median follow-up of 60 months (interquartile range: 39–86), 432 men experienced BCR. BCRFS was lower in group 3 than in groups 1 and 2 (p < 0.001 and p = 0.021, respectively). In multivariate analysis, this association persisted and surgical margin (SM) was found to be a significant BCR predictor. Although statistically not significant, BCRFS was lower in group 3 with positive SM (PSM) than in group 2 with PSM (p = 0.101). BCRFS was significantly worse in group 3 with negative SM (NSM) than in group 1 with PSM (p = 0.038), while it was better in group 2 with PSM (p = 0.297). Conclusion: Localized high-grade PC with PSM showed lower BCRFS and that with NSM showed better BCRFS without statistical significance than locally advanced GS 7 PC with PSM that are eligible for ART.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalJournal of cancer research and clinical oncology
Volume146
Issue number1
DOIs
Publication statusPublished - 2020 Jan 1

Bibliographical note

Funding Information:
This study was supported by a faculty research grant from the Yonsei University College of Medicine (6-2016-0067).

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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