Postoperative course of Crohn disease according to timing of bowel resection Results from the CONNECT Study

Ji Min Lee, Kang Moon Lee, Joo Sung Kim, You Sun Kim, Jae Hee Cheon, Byong Duk Ye, Young Ho Kim, Dong Soo Han, Chang Kyun Lee, Hyun Ju Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Previous studies have demonstrated that early surgery in Crohn disease (CD) can result in a better clinical course than late surgery. The aim of this study was to compare the clinical course of CD following bowel resection performed at the time of diagnosis (early surgery) and during the course of the disease (late surgery). We reviewed medical records from a hospital-based cohort database that includes Korean CD patients diagnosed before 2009. Patients who underwent bowel resection were included. Age, sex, disease phenotype, time of surgery, medication history including use of corticosteroids, immunomodulators, and biologics, and further surgical history were assessed. In all, 243 CD patients who had undergone bowel resection were included, and 120 patients underwent surgery at the time of diagnosis, while 123 underwent surgery after diagnosis (median 105 months, range 2–277). The use of biologics was significantly higher in the late surgery group than in the early surgery group (P = .020). The use of immunomodulators and reoperation rates did not differ between the groups. Early surgery was associated with less use of biologics (Kaplan–Meier curve analysis P = .015). Multivariate analysis indicated that early surgery and old age at surgery were independent variables associated with less use of biologics. CD patients who underwent bowel resection at the time of diagnosis have a more favorable disease course, represented by less use of biologics. Early surgery might be a treatment option in a subset of CD patients.

Original languageEnglish
Article numbere0459
JournalMedicine (United States)
Volume97
Issue number16
DOIs
Publication statusPublished - 2018 Apr

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Crohn Disease
Biological Products
Immunologic Factors
Reoperation
Medical Records
Adrenal Cortex Hormones
Multivariate Analysis
History
Databases
Phenotype

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Ji Min ; Lee, Kang Moon ; Kim, Joo Sung ; Kim, You Sun ; Cheon, Jae Hee ; Ye, Byong Duk ; Kim, Young Ho ; Han, Dong Soo ; Lee, Chang Kyun ; Park, Hyun Ju. / Postoperative course of Crohn disease according to timing of bowel resection Results from the CONNECT Study. In: Medicine (United States). 2018 ; Vol. 97, No. 16.
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Postoperative course of Crohn disease according to timing of bowel resection Results from the CONNECT Study. / Lee, Ji Min; Lee, Kang Moon; Kim, Joo Sung; Kim, You Sun; Cheon, Jae Hee; Ye, Byong Duk; Kim, Young Ho; Han, Dong Soo; Lee, Chang Kyun; Park, Hyun Ju.

In: Medicine (United States), Vol. 97, No. 16, e0459, 04.2018.

Research output: Contribution to journalArticle

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