Postoperative helicobacter pylori infection as a prognostic factor for gastric cancer patients after curative resection

Da Hyun Jung, Yongchan Lee, Jie-Hyun Kim, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, SangKil Lee, Hyoung Il Kim, WooJin Hyung, Sung Hoon Noh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Few studies have evaluated the effect of Helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between the H. pylori infection status and clinical outcome after surgery. Methods: We assessed the H. pylori status of 314 patients who underwent curative resection for GC. The H. pylori status was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery. Results: An H. pylori infection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients with H. pylori had a higher cumulative survival rate than those who were negative for H. pylori. Patients with stage II cancer who tested negative for H. pylori were associated with a poor outcome. In a multivariate analysis, H. pylori-negative status was a significant independent prognostic factor for poor overall survival. Conclusions: Having a negative H. pylori infection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by which H. pylori affects GC patients after curative surgery in Korea.

Original languageEnglish
Pages (from-to)635-641
Number of pages7
JournalGut and liver
Volume11
Issue number5
DOIs
Publication statusPublished - 2017 Sep 1

Fingerprint

Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Urease
Kaplan-Meier Estimate
Korea
Multivariate Analysis
Survival Rate
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Jung, Da Hyun ; Lee, Yongchan ; Kim, Jie-Hyun ; Chung, Hyunsoo ; Park, Jun Chul ; Shin, Sung Kwan ; Lee, SangKil ; Kim, Hyoung Il ; Hyung, WooJin ; Noh, Sung Hoon. / Postoperative helicobacter pylori infection as a prognostic factor for gastric cancer patients after curative resection. In: Gut and liver. 2017 ; Vol. 11, No. 5. pp. 635-641.
@article{aeeace2ddca6446895701b02fe0bf934,
title = "Postoperative helicobacter pylori infection as a prognostic factor for gastric cancer patients after curative resection",
abstract = "Background/Aims: Few studies have evaluated the effect of Helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between the H. pylori infection status and clinical outcome after surgery. Methods: We assessed the H. pylori status of 314 patients who underwent curative resection for GC. The H. pylori status was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery. Results: An H. pylori infection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients with H. pylori had a higher cumulative survival rate than those who were negative for H. pylori. Patients with stage II cancer who tested negative for H. pylori were associated with a poor outcome. In a multivariate analysis, H. pylori-negative status was a significant independent prognostic factor for poor overall survival. Conclusions: Having a negative H. pylori infection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by which H. pylori affects GC patients after curative surgery in Korea.",
author = "Jung, {Da Hyun} and Yongchan Lee and Jie-Hyun Kim and Hyunsoo Chung and Park, {Jun Chul} and Shin, {Sung Kwan} and SangKil Lee and Kim, {Hyoung Il} and WooJin Hyung and Noh, {Sung Hoon}",
year = "2017",
month = "9",
day = "1",
doi = "10.5009/gnl16397",
language = "English",
volume = "11",
pages = "635--641",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "5",

}

Postoperative helicobacter pylori infection as a prognostic factor for gastric cancer patients after curative resection. / Jung, Da Hyun; Lee, Yongchan; Kim, Jie-Hyun; Chung, Hyunsoo; Park, Jun Chul; Shin, Sung Kwan; Lee, SangKil; Kim, Hyoung Il; Hyung, WooJin; Noh, Sung Hoon.

In: Gut and liver, Vol. 11, No. 5, 01.09.2017, p. 635-641.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Postoperative helicobacter pylori infection as a prognostic factor for gastric cancer patients after curative resection

AU - Jung, Da Hyun

AU - Lee, Yongchan

AU - Kim, Jie-Hyun

AU - Chung, Hyunsoo

AU - Park, Jun Chul

AU - Shin, Sung Kwan

AU - Lee, SangKil

AU - Kim, Hyoung Il

AU - Hyung, WooJin

AU - Noh, Sung Hoon

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background/Aims: Few studies have evaluated the effect of Helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between the H. pylori infection status and clinical outcome after surgery. Methods: We assessed the H. pylori status of 314 patients who underwent curative resection for GC. The H. pylori status was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery. Results: An H. pylori infection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients with H. pylori had a higher cumulative survival rate than those who were negative for H. pylori. Patients with stage II cancer who tested negative for H. pylori were associated with a poor outcome. In a multivariate analysis, H. pylori-negative status was a significant independent prognostic factor for poor overall survival. Conclusions: Having a negative H. pylori infection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by which H. pylori affects GC patients after curative surgery in Korea.

AB - Background/Aims: Few studies have evaluated the effect of Helicobacter pylori infection on the prognosis of patients diagnosed with gastric cancer (GC) after curative surgery. We investigated the association between the H. pylori infection status and clinical outcome after surgery. Methods: We assessed the H. pylori status of 314 patients who underwent curative resection for GC. The H. pylori status was examined using a rapid urease test 2 months after resection. Patients were followed for 10 years after surgery. Results: An H. pylori infection was observed in 128 of 314 patients. The median follow-up period was 93.5 months. A Kaplan-Meier analysis indicated that patients with H. pylori had a higher cumulative survival rate than those who were negative for H. pylori. Patients with stage II cancer who tested negative for H. pylori were associated with a poor outcome. In a multivariate analysis, H. pylori-negative status was a significant independent prognostic factor for poor overall survival. Conclusions: Having a negative H. pylori infection status seems to indicate poor prognosis for patients with GC who have undergone curative resection. Further prospective controlled studies are needed to evaluate the mechanism by which H. pylori affects GC patients after curative surgery in Korea.

UR - http://www.scopus.com/inward/record.url?scp=85032015298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032015298&partnerID=8YFLogxK

U2 - 10.5009/gnl16397

DO - 10.5009/gnl16397

M3 - Article

VL - 11

SP - 635

EP - 641

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 5

ER -