Potential application of ixeris dentata in the prevention and treatment of aging-induced dry mouth

Kashi Raj Bhattarai, Hwa Young Lee, Seung Hyun Kim, Jong Sug Park, Hyung Ryong Kim, Han Jung Chae

Research output: Contribution to journalArticle

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Abstract

Dry mouth is a common complaint among the elderly population. The aim of this study was to investigate the effect of Ixeris dentata (IXD) extract on aging-induced dry mouth. We used young (two months) and aged (20 months) SD rats in our study. Using water as the vehicle, IXD extract (25, 50, and 100 mg/kg) was given via oral gavage to the young and aged rats for eight weeks. We found that the salivary flow rate relative to the submandibular gland weight was differently influenced by IXD extract treatment. IXD extract augmented the submandibular gland acinar cells, which are depleted during aging. In addition, the decreased salivary alpha-amylase, inositol triphosphate receptor, and aquaporin-5 in the aging rats were upregulated by IXD treatment. Free radical-induced oxidative stress in the aging rats was also alleviated in the IXD-treated group. The formation of high molecular weight complexes of protein disulfide isomerase, decreased expression of an ER chaperone (GRP78), and increased ER stress response (ATF-4, CHOP and p-JNK) in aging rats was regulated with IXD treatment, and eventually increased salivary secretions from the aging submandibular glands. These are the first data to suggest that IXD extract might ameliorate aging-associated oral dryness by regulating the ER environment.

Original languageEnglish
Article number1989
JournalNutrients
Volume10
Issue number12
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Asteraceae
Mouth
mouth
rats
extracts
Submandibular Gland
protein disulfide-isomerase
Therapeutics
acinar cells
aquaporins
Aquaporin 5
Salivary alpha-Amylases
alpha-amylase
Protein Disulfide-Isomerases
stress response
Inositol 1,4,5-Trisphosphate Receptors
Xerostomia
oxidative stress
Acinar Cells
secretion

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Bhattarai, Kashi Raj ; Lee, Hwa Young ; Kim, Seung Hyun ; Park, Jong Sug ; Kim, Hyung Ryong ; Chae, Han Jung. / Potential application of ixeris dentata in the prevention and treatment of aging-induced dry mouth. In: Nutrients. 2018 ; Vol. 10, No. 12.
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Potential application of ixeris dentata in the prevention and treatment of aging-induced dry mouth. / Bhattarai, Kashi Raj; Lee, Hwa Young; Kim, Seung Hyun; Park, Jong Sug; Kim, Hyung Ryong; Chae, Han Jung.

In: Nutrients, Vol. 10, No. 12, 1989, 01.01.2018.

Research output: Contribution to journalArticle

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