Dry mouth is a common complaint among the elderly population. The aim of this study was to investigate the effect of Ixeris dentata (IXD) extract on aging-induced dry mouth. We used young (two months) and aged (20 months) SD rats in our study. Using water as the vehicle, IXD extract (25, 50, and 100 mg/kg) was given via oral gavage to the young and aged rats for eight weeks. We found that the salivary flow rate relative to the submandibular gland weight was differently influenced by IXD extract treatment. IXD extract augmented the submandibular gland acinar cells, which are depleted during aging. In addition, the decreased salivary alpha-amylase, inositol triphosphate receptor, and aquaporin-5 in the aging rats were upregulated by IXD treatment. Free radical-induced oxidative stress in the aging rats was also alleviated in the IXD-treated group. The formation of high molecular weight complexes of protein disulfide isomerase, decreased expression of an ER chaperone (GRP78), and increased ER stress response (ATF-4, CHOP and p-JNK) in aging rats was regulated with IXD treatment, and eventually increased salivary secretions from the aging submandibular glands. These are the first data to suggest that IXD extract might ameliorate aging-associated oral dryness by regulating the ER environment.
Bibliographical noteFunding Information:
K., J.-S. P. and H.-J.C.; Project administration, H.-R.K. and H.-J.C.; Resources, H.-R.K. and H.-J.C.; Supervision, their association with quality of life in elderly patients in dependence on dental status and prosthetic H.-J.C.; Validation, H.-R.K. and H.-J.C.; Writing-original draft, K.R.B.; Writing-review & editing, K.R.B., rehabilitation: A pilot study. J. Dent. 2014, 42, 664–670. [CrossRef] [PubMed] H.-Y.L., S.-H. K., H.-R.K. and H.-J.C. 2. Ship, J.A.; Pillemer, S.R.; Baum, B.J. Xerostomia and the geriatric patient. J. Am. Geriatr. Soc. 2002, 50, 535–543. Funding: This work was carried out with the support of the Cooperative Research Program for Agriculture
Funding: This work was carried out with the support of the Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01158104), funded by the Rural Development Administration, Republic of Korea. This study was also supported by the Korean National Research Foundation (2017R1E1A1A01073796) and 2017M3A9G7072719).
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All Science Journal Classification (ASJC) codes
- Food Science
- Nutrition and Dietetics