Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage

Yeon hee Kim, Amy Cho, Sang Ah Kwon, Minju Kim, Mina Song, Hye won Han, Eun Ji Shin, Eunju Park, Seung Min Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ultraviolet B (UVB) irradiation causes adverse effects on the skin. Corn silk contains flavonoids and other bioactive compounds and antioxidants, which may prevent skin photoaging through antioxidant and anti-inflammatory effects. We aimed to investigate the potential photoprotective effects of dietary corn silk on UVB-induced skin damage in mice and the mechanisms behind these effects on human skin cells. Oral administration of corn silk water extract (CS) (2 or 4 g/kg/day) for 19 weeks decreased epidermal thickness, wrinkle formation, and positive staining for PCNA, Ki67, and 8-OHdG, and increased collagen staining in UVB-irradiated SKH-1 hairless mice compared with controls. The pro-inflammatory NF-κB target genes (IL-1β, iNOS, and COX-2) and MMP-9 expressions were lower in the CS groups, and TGF-β/Smad signaling increased. Low skin lipid peroxidation and blood DNA oxidation levels and high blood glutathione were detected. Antioxidant transcription factor Nrf2-related catalase and SOD1 proteins and glutaredoxin mRNA levels increased. The results of CS extract treatment and UVB irradiation in HaCaT cells showed the same results in Nrf2 and NF-κB target genes. An LC-MS/MS analysis showed that the CS extract contained potential antioxidants, which might have contributed to its anti-photoaging effects in tissues and cells. CS extract may reduce UVB-induced skin damage through antioxidant and anti-inflammatory mechanisms.

Original languageEnglish
Article number2587;
JournalMolecules
Volume24
Issue number14
DOIs
Publication statusPublished - 2019 Jul 16

Fingerprint

silk
corn
Silk
antioxidants
Zea mays
Skin
Antioxidants
damage
staining
genes
blood
mice
Anti-Inflammatory Agents
cells
Glutaredoxins
Staining and Labeling
Blood
Skin Aging
Hairless Mouse
catalase

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Kim, Yeon hee ; Cho, Amy ; Kwon, Sang Ah ; Kim, Minju ; Song, Mina ; Han, Hye won ; Shin, Eun Ji ; Park, Eunju ; Lee, Seung Min. / Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage. In: Molecules. 2019 ; Vol. 24, No. 14.
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abstract = "Ultraviolet B (UVB) irradiation causes adverse effects on the skin. Corn silk contains flavonoids and other bioactive compounds and antioxidants, which may prevent skin photoaging through antioxidant and anti-inflammatory effects. We aimed to investigate the potential photoprotective effects of dietary corn silk on UVB-induced skin damage in mice and the mechanisms behind these effects on human skin cells. Oral administration of corn silk water extract (CS) (2 or 4 g/kg/day) for 19 weeks decreased epidermal thickness, wrinkle formation, and positive staining for PCNA, Ki67, and 8-OHdG, and increased collagen staining in UVB-irradiated SKH-1 hairless mice compared with controls. The pro-inflammatory NF-κB target genes (IL-1β, iNOS, and COX-2) and MMP-9 expressions were lower in the CS groups, and TGF-β/Smad signaling increased. Low skin lipid peroxidation and blood DNA oxidation levels and high blood glutathione were detected. Antioxidant transcription factor Nrf2-related catalase and SOD1 proteins and glutaredoxin mRNA levels increased. The results of CS extract treatment and UVB irradiation in HaCaT cells showed the same results in Nrf2 and NF-κB target genes. An LC-MS/MS analysis showed that the CS extract contained potential antioxidants, which might have contributed to its anti-photoaging effects in tissues and cells. CS extract may reduce UVB-induced skin damage through antioxidant and anti-inflammatory mechanisms.",
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Kim, YH, Cho, A, Kwon, SA, Kim, M, Song, M, Han, HW, Shin, EJ, Park, E & Lee, SM 2019, 'Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage', Molecules, vol. 24, no. 14, 2587;. https://doi.org/10.3390/molecules24142587

Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage. / Kim, Yeon hee; Cho, Amy; Kwon, Sang Ah; Kim, Minju; Song, Mina; Han, Hye won; Shin, Eun Ji; Park, Eunju; Lee, Seung Min.

In: Molecules, Vol. 24, No. 14, 2587;, 16.07.2019.

Research output: Contribution to journalArticle

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AU - Lee, Seung Min

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