Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage

Yeon hee Kim, Amy Cho, Sang Ah Kwon, Minju Kim, Mina Song, Hye won Han, Eun Ji Shin, Eunju Park, Seung Min Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ultraviolet B (UVB) irradiation causes adverse effects on the skin. Corn silk contains flavonoids and other bioactive compounds and antioxidants, which may prevent skin photoaging through antioxidant and anti-inflammatory effects. We aimed to investigate the potential photoprotective effects of dietary corn silk on UVB-induced skin damage in mice and the mechanisms behind these effects on human skin cells. Oral administration of corn silk water extract (CS) (2 or 4 g/kg/day) for 19 weeks decreased epidermal thickness, wrinkle formation, and positive staining for PCNA, Ki67, and 8-OHdG, and increased collagen staining in UVB-irradiated SKH-1 hairless mice compared with controls. The pro-inflammatory NF-κB target genes (IL-1β, iNOS, and COX-2) and MMP-9 expressions were lower in the CS groups, and TGF-β/Smad signaling increased. Low skin lipid peroxidation and blood DNA oxidation levels and high blood glutathione were detected. Antioxidant transcription factor Nrf2-related catalase and SOD1 proteins and glutaredoxin mRNA levels increased. The results of CS extract treatment and UVB irradiation in HaCaT cells showed the same results in Nrf2 and NF-κB target genes. An LC-MS/MS analysis showed that the CS extract contained potential antioxidants, which might have contributed to its anti-photoaging effects in tissues and cells. CS extract may reduce UVB-induced skin damage through antioxidant and anti-inflammatory mechanisms.

Original languageEnglish
Article number2587;
JournalMolecules
Volume24
Issue number14
DOIs
Publication statusPublished - 2019 Jul 16

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Kim, Y. H., Cho, A., Kwon, S. A., Kim, M., Song, M., Han, H. W., Shin, E. J., Park, E., & Lee, S. M. (2019). Potential photoprotective effect of dietary corn silk extract on ultraviolet B-induced skin damage. Molecules, 24(14), [2587;]. https://doi.org/10.3390/molecules24142587