Potential threats of nanoplastic accumulation in human induced pluripotent stem cells

Hyejoong Jeong; Wijin Kim; Daheui Choi; Jiwoong Heo; Uiyoung Han; Se Yong Jung; Hee Ho Park; Sung Tae Hong; Ju Hyun Park; Jinkee Hong

doi:10.1016/j.cej.2021.131841

Potential threats of nanoplastic accumulation in human induced pluripotent stem cells

Hyejoong Jeong, Wijin Kim, Daheui Choi, Jiwoong Heo, Uiyoung Han, Se Yong Jung, Hee Ho Park, Sung Tae Hong, Ju Hyun Park, Jinkee Hong

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The threat to humans from nanoplastics (NPs) is increasing invisibly. Nowadays, many people are concerned about human safety and health, but few are reported about the effects of NP on humans. To overcome the limitations in human studies, human induced pluripotent stem cells (hiPSCs) were used as an optimal platform to investigate toxicity and subtle changes in differentiation caused by intracellular NPs accumulation for a long-term. Negatively charged polystyrene nanoplastics (PS NPs) were used to exclude acute toxic issues of surface charge and investigate the impact of the NP's size and nature during bioaccumulation. Intracellular observations revealed that excessive amounts of NPs were internalized into single cells and colonies within 48 h. Substantial growth inhibition and a slight reduction in self renewal capacity of hiPSCs occurred with respect to internalized NPs. Unexpectedly, the accumulated NPs in hiPSC did not exhibit chronic toxicity or adversely affect differentiation for 14 days.

Original language	English
Article number	131841
Journal	Chemical Engineering Journal
Volume	427
DOIs	https://doi.org/10.1016/j.cej.2021.131841
Publication status	Published - 2022 Jan 1

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science and ICT of the Korean government (2016M3A9C6917402, 2016M3A9C6917405, 2019M3A9H110378611). In addition, this research was also supported by the Basic Science Research Program through the NRF (NRF-2017R1E1A1A01074343, 2020R1A4A1016093, 2021R1A2C1010865).

Publisher Copyright:
© 2021 Elsevier B.V.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Environmental Chemistry
Chemical Engineering(all)
Industrial and Manufacturing Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cej.2021.131841

Cite this

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title = "Potential threats of nanoplastic accumulation in human induced pluripotent stem cells",

abstract = "The threat to humans from nanoplastics (NPs) is increasing invisibly. Nowadays, many people are concerned about human safety and health, but few are reported about the effects of NP on humans. To overcome the limitations in human studies, human induced pluripotent stem cells (hiPSCs) were used as an optimal platform to investigate toxicity and subtle changes in differentiation caused by intracellular NPs accumulation for a long-term. Negatively charged polystyrene nanoplastics (PS NPs) were used to exclude acute toxic issues of surface charge and investigate the impact of the NP's size and nature during bioaccumulation. Intracellular observations revealed that excessive amounts of NPs were internalized into single cells and colonies within 48 h. Substantial growth inhibition and a slight reduction in self renewal capacity of hiPSCs occurred with respect to internalized NPs. Unexpectedly, the accumulated NPs in hiPSC did not exhibit chronic toxicity or adversely affect differentiation for 14 days.",

author = "Hyejoong Jeong and Wijin Kim and Daheui Choi and Jiwoong Heo and Uiyoung Han and Jung, {Se Yong} and Park, {Hee Ho} and Hong, {Sung Tae} and Park, {Ju Hyun} and Jinkee Hong",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science and ICT of the Korean government (2016M3A9C6917402, 2016M3A9C6917405, 2019M3A9H110378611). In addition, this research was also supported by the Basic Science Research Program through the NRF (NRF-2017R1E1A1A01074343, 2020R1A4A1016093, 2021R1A2C1010865). Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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Potential threats of nanoplastic accumulation in human induced pluripotent stem cells

Abstract

Bibliographical note

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UN SDGs

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