Power partial-discard strategy to obtain improved performance for simulated moving bed chromatography

Ji Woo Chung, Kyung Min Kim, Tae Ung Yoon, Seung Ik Kim, Tae Sung Jung, Sang Sup Han, Youn Sang Bae

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1 Citation (Scopus)


A novel power partial-discard (PPD) strategy was developed as a variant of the partial-discard (PD) operation to further improve the separation performance of the simulated moving bed (SMB) process. The PPD operation varied the flow rates of discard streams by introducing a new variable, the discard amount (DA) as well as varying the reported variable, discard length (DL), while the conventional PD used fixed discard flow rates. The PPD operations showed significantly improved purities in spite of losses in recoveries. Remarkably, the PPD operation could provide more enhanced purity for a given recovery or more enhanced recovery for a given purity than the PD operation. The two variables, DA and DL, in the PPD operation played a key role in achieving the desired purity and recovery. The PPD operations will be useful for attaining high-purity products with reasonable recoveries.

Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalJournal of Chromatography A
Publication statusPublished - 2017 Dec 22


All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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