Background: Although the need to detect restenosis has diminished in the contemporary practice of percutaneous coronary intervention (PCI) with drug-eluting stents (DES), the surveillance of ischemia owing to restenosis or disease progression deserves attention in high-risk PCI settings. It is unknown whether follow-up strategy of routine noninvasive functional testing potentially reduces the risk of major cardiovascular events in high-risk PCI patients. Methods: The POST-PCI study is an investigator-initiated, multicenter, prospective randomized trial comparing the effectiveness of two follow-up strategies in patients with high-risk anatomic or clinical characteristics who underwent PCI. Study participants were randomly assigned to either (1) the routine noninvasive stress testing (exercise electrocardiography, nuclear stress imaging, or stress echocardiography) at 12 months post-PCI or (2) the standard-care without routine testing. In the routine stress testing group, depending on the testing results, all clinical decisions regarding subsequent diagnostic or therapeutic procedures were at the treating physician's discretion. The primary endpoint was a composite outcome of death from any causes, myocardial infarction, or hospitalization for unstable angina at 2 years post-PCI. Results: More than 1700 high-risk PCI patients have been randomized over 2.0 years at 11 major cardiac centers in Korea. Conclusion: This pragmatic POST-PCI trial will provide valuable clinical evidence on the effectiveness of follow-up strategy of routine noninvasive stress testing in high-risk PCI patients.
|Number of pages||10|
|Journal||American heart journal|
|Publication status||Published - 2020 Jun|
Bibliographical noteFunding Information:
The POST-PCI trial is an investigator-initiated trial partly funded by the CardioVascular Research Foundation (CVRF, Seoul, Korea) and the Daewoong Pharmaceutical (Seoul, Korea). It is conducted under the supervision of an executive committee that developed the protocol and oversees trial execution, the independent database, and analysis of the results and publication. The executive committee approved the final trial design and protocol issued to the Data and Safety Monitoring Board (DSMB) and the clinical sites. A steering committee of investigators provides operational expertise and advises the executive committee. Overall, operational oversight of the study is performed through the Clinical Research Center in Asan Medical Center, Seoul, Korea. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the paper and its final contents.
© 2020 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine