Pre-clinical evaluation of the osteogenic potential of bone morphogenetic protein-2 loaded onto a particulate porcine bone biomaterial

Jeyoung Yon, Jung Seok Lee, Hyun Chang Lim, Min Soo Kim, Ji Youn Hong, Seong Ho Choi, Ui Won Jung

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aim The objective of study was to determine the osteogenic potential of bone morphogenetic protein-2 (BMP-2) loaded onto a particulate porcine bone mineral (PBM) biomaterial using a sinus augmentation model. Methods Release kinetics of BMP-2/PBM was determined in vitro. Eight rabbits received BMP-2/PBM or PBM alone into contra-lateral sinus sites. The animals were killed following a 2-week healing interval for micro-CT and histometrical analysis. Results Approximately 40% of the BMP-2 was released from PBM over the first 3 days in vitro; release maintained at a reduced level through day 21. In vivo, total augmented implant volume did not differ significantly between treatments. However, local bone formation was enhanced in the BMP-2/PBM group compared with PBM control (10.5% versus 6.6%; p = 0.03), specifically in the central aspect of the PBM implant (14.2% versus 5.5%; p < 0.01) and adjoining the Schneiderian membrane (11.9% versus 5.0%; p < 0.05). There were no significant overall differences in residual biomaterial and fibrovascular tissue. Conclusion Bone morphogenetic protein-2 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a PBM carrier.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalJournal of Clinical Periodontology
Volume42
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Bone Morphogenetic Protein 2
Biocompatible Materials
Minerals
Swine
Bone and Bones
Osteogenesis
Transverse Sinuses
Rabbits
Maxillary Sinus
Nasal Mucosa

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

@article{76e464357706481b8168ec2e34870303,
title = "Pre-clinical evaluation of the osteogenic potential of bone morphogenetic protein-2 loaded onto a particulate porcine bone biomaterial",
abstract = "Aim The objective of study was to determine the osteogenic potential of bone morphogenetic protein-2 (BMP-2) loaded onto a particulate porcine bone mineral (PBM) biomaterial using a sinus augmentation model. Methods Release kinetics of BMP-2/PBM was determined in vitro. Eight rabbits received BMP-2/PBM or PBM alone into contra-lateral sinus sites. The animals were killed following a 2-week healing interval for micro-CT and histometrical analysis. Results Approximately 40{\%} of the BMP-2 was released from PBM over the first 3 days in vitro; release maintained at a reduced level through day 21. In vivo, total augmented implant volume did not differ significantly between treatments. However, local bone formation was enhanced in the BMP-2/PBM group compared with PBM control (10.5{\%} versus 6.6{\%}; p = 0.03), specifically in the central aspect of the PBM implant (14.2{\%} versus 5.5{\%}; p < 0.01) and adjoining the Schneiderian membrane (11.9{\%} versus 5.0{\%}; p < 0.05). There were no significant overall differences in residual biomaterial and fibrovascular tissue. Conclusion Bone morphogenetic protein-2 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a PBM carrier.",
author = "Jeyoung Yon and Lee, {Jung Seok} and Lim, {Hyun Chang} and Kim, {Min Soo} and Hong, {Ji Youn} and Choi, {Seong Ho} and Jung, {Ui Won}",
year = "2015",
month = "1",
day = "1",
doi = "10.1111/jcpe.12329",
language = "English",
volume = "42",
pages = "81--88",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Blackwell Munksgaard",
number = "1",

}

Pre-clinical evaluation of the osteogenic potential of bone morphogenetic protein-2 loaded onto a particulate porcine bone biomaterial. / Yon, Jeyoung; Lee, Jung Seok; Lim, Hyun Chang; Kim, Min Soo; Hong, Ji Youn; Choi, Seong Ho; Jung, Ui Won.

In: Journal of Clinical Periodontology, Vol. 42, No. 1, 01.01.2015, p. 81-88.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pre-clinical evaluation of the osteogenic potential of bone morphogenetic protein-2 loaded onto a particulate porcine bone biomaterial

AU - Yon, Jeyoung

AU - Lee, Jung Seok

AU - Lim, Hyun Chang

AU - Kim, Min Soo

AU - Hong, Ji Youn

AU - Choi, Seong Ho

AU - Jung, Ui Won

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Aim The objective of study was to determine the osteogenic potential of bone morphogenetic protein-2 (BMP-2) loaded onto a particulate porcine bone mineral (PBM) biomaterial using a sinus augmentation model. Methods Release kinetics of BMP-2/PBM was determined in vitro. Eight rabbits received BMP-2/PBM or PBM alone into contra-lateral sinus sites. The animals were killed following a 2-week healing interval for micro-CT and histometrical analysis. Results Approximately 40% of the BMP-2 was released from PBM over the first 3 days in vitro; release maintained at a reduced level through day 21. In vivo, total augmented implant volume did not differ significantly between treatments. However, local bone formation was enhanced in the BMP-2/PBM group compared with PBM control (10.5% versus 6.6%; p = 0.03), specifically in the central aspect of the PBM implant (14.2% versus 5.5%; p < 0.01) and adjoining the Schneiderian membrane (11.9% versus 5.0%; p < 0.05). There were no significant overall differences in residual biomaterial and fibrovascular tissue. Conclusion Bone morphogenetic protein-2 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a PBM carrier.

AB - Aim The objective of study was to determine the osteogenic potential of bone morphogenetic protein-2 (BMP-2) loaded onto a particulate porcine bone mineral (PBM) biomaterial using a sinus augmentation model. Methods Release kinetics of BMP-2/PBM was determined in vitro. Eight rabbits received BMP-2/PBM or PBM alone into contra-lateral sinus sites. The animals were killed following a 2-week healing interval for micro-CT and histometrical analysis. Results Approximately 40% of the BMP-2 was released from PBM over the first 3 days in vitro; release maintained at a reduced level through day 21. In vivo, total augmented implant volume did not differ significantly between treatments. However, local bone formation was enhanced in the BMP-2/PBM group compared with PBM control (10.5% versus 6.6%; p = 0.03), specifically in the central aspect of the PBM implant (14.2% versus 5.5%; p < 0.01) and adjoining the Schneiderian membrane (11.9% versus 5.0%; p < 0.05). There were no significant overall differences in residual biomaterial and fibrovascular tissue. Conclusion Bone morphogenetic protein-2 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a PBM carrier.

UR - http://www.scopus.com/inward/record.url?scp=84921038524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921038524&partnerID=8YFLogxK

U2 - 10.1111/jcpe.12329

DO - 10.1111/jcpe.12329

M3 - Article

C2 - 25370371

AN - SCOPUS:84921038524

VL - 42

SP - 81

EP - 88

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 1

ER -