Preceding orbital granulocytic sarcoma in an adult patient with acute myelogenous leukemia with t(8;21): a case study and review of the literature.

Sang Guk Lee, Tae Sung Park, June Won Cheong, Woo Ick Yang, Jaewoo Song, Kyunga Lee, Juwon Kim, Yongjung Park, Jong Rak Choi

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

A 25-year old man with a 30 month history of proptosis and pain of the right eye was referred to Severance Hospital of Yonsei University. Orbital computed tomography (CT) demonstrated a huge mass in the right retrobulbar orbit; an incisional biopsy and orbitotomy were performed for diagnosis and orbital soft tissue decompression. Subsequent histopathology disclosed sheets of mononuclear cells in the orbital mass, and immunohistochemical stains demonstrated positive results for myeloperoxidase and CD43, which supported the diagnosis of granulocytic sarcoma (GS). After his 1-year follow-up, the patient presented with pancytopenia, and an ensuing bone marrow aspiration revealed markedly hypercellular marrow replaced by many large abnormal myeloblasts. The patient was diagnosed with acute myelogenous leukemia with t(8;21) preceded by orbital GS. Orbital GS is primarily a disease of children, and extremely rare in adults. To the best of our knowledge, only four cases of this disease in adults have been reported in the literature. Our case is the first report of preceding orbital GS in an adult patient with a complex karyotype including t(8;21).

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalCancer genetics and cytogenetics
Volume185
Issue number1
Publication statusPublished - 2008 Jan 1

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Myeloid Sarcoma
Acute Myeloid Leukemia
Bone Marrow
Eye Pain
Granulocyte Precursor Cells
Pancytopenia
Exophthalmos
Orbit
Decompression
Karyotype
Peroxidase
Coloring Agents
Tomography
Biopsy

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Lee, Sang Guk ; Park, Tae Sung ; Cheong, June Won ; Yang, Woo Ick ; Song, Jaewoo ; Lee, Kyunga ; Kim, Juwon ; Park, Yongjung ; Choi, Jong Rak. / Preceding orbital granulocytic sarcoma in an adult patient with acute myelogenous leukemia with t(8;21) : a case study and review of the literature. In: Cancer genetics and cytogenetics. 2008 ; Vol. 185, No. 1. pp. 51-54.
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Preceding orbital granulocytic sarcoma in an adult patient with acute myelogenous leukemia with t(8;21) : a case study and review of the literature. / Lee, Sang Guk; Park, Tae Sung; Cheong, June Won; Yang, Woo Ick; Song, Jaewoo; Lee, Kyunga; Kim, Juwon; Park, Yongjung; Choi, Jong Rak.

In: Cancer genetics and cytogenetics, Vol. 185, No. 1, 01.01.2008, p. 51-54.

Research output: Contribution to journalReview article

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T2 - a case study and review of the literature.

AU - Lee, Sang Guk

AU - Park, Tae Sung

AU - Cheong, June Won

AU - Yang, Woo Ick

AU - Song, Jaewoo

AU - Lee, Kyunga

AU - Kim, Juwon

AU - Park, Yongjung

AU - Choi, Jong Rak

PY - 2008/1/1

Y1 - 2008/1/1

N2 - A 25-year old man with a 30 month history of proptosis and pain of the right eye was referred to Severance Hospital of Yonsei University. Orbital computed tomography (CT) demonstrated a huge mass in the right retrobulbar orbit; an incisional biopsy and orbitotomy were performed for diagnosis and orbital soft tissue decompression. Subsequent histopathology disclosed sheets of mononuclear cells in the orbital mass, and immunohistochemical stains demonstrated positive results for myeloperoxidase and CD43, which supported the diagnosis of granulocytic sarcoma (GS). After his 1-year follow-up, the patient presented with pancytopenia, and an ensuing bone marrow aspiration revealed markedly hypercellular marrow replaced by many large abnormal myeloblasts. The patient was diagnosed with acute myelogenous leukemia with t(8;21) preceded by orbital GS. Orbital GS is primarily a disease of children, and extremely rare in adults. To the best of our knowledge, only four cases of this disease in adults have been reported in the literature. Our case is the first report of preceding orbital GS in an adult patient with a complex karyotype including t(8;21).

AB - A 25-year old man with a 30 month history of proptosis and pain of the right eye was referred to Severance Hospital of Yonsei University. Orbital computed tomography (CT) demonstrated a huge mass in the right retrobulbar orbit; an incisional biopsy and orbitotomy were performed for diagnosis and orbital soft tissue decompression. Subsequent histopathology disclosed sheets of mononuclear cells in the orbital mass, and immunohistochemical stains demonstrated positive results for myeloperoxidase and CD43, which supported the diagnosis of granulocytic sarcoma (GS). After his 1-year follow-up, the patient presented with pancytopenia, and an ensuing bone marrow aspiration revealed markedly hypercellular marrow replaced by many large abnormal myeloblasts. The patient was diagnosed with acute myelogenous leukemia with t(8;21) preceded by orbital GS. Orbital GS is primarily a disease of children, and extremely rare in adults. To the best of our knowledge, only four cases of this disease in adults have been reported in the literature. Our case is the first report of preceding orbital GS in an adult patient with a complex karyotype including t(8;21).

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