Predicting liver-related events using transient elastography in chronic hepatitis C patients with sustained virological response

Hye Won Lee, Young Eun Chon, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kyu Sik Jung, Young Nyun Park, Kwang Hyub Han

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background/Aims: Few studies have investigated prognostic factors for the development of liver-related events (LREs) in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). Methods: We analyzed 190 patients with CHC who achieved SVR after treatment with pegylated interferon (peg-IFN) plus ribavirin. LREs were defined as any complications related to cirrhosis, hepatocellular carcinoma (HCC), or liver-related mortality. Results: The mean age was 54.1 years, and 84 of the patients (44.2%) were male. The mean liver stiffness (LS) value at SVR was 7.1±5.4 kPa. During the follow-up period (median, 43.0 months), LREs occurred in 10 patients (5.3%; HCC in eight patients, ascites in one patient, and liver-related mortality in one patient). By multivariate Cox regression analysis, age, a-fetoprotein level, and LS value were independent predictors for LRE development (all p < 0.05). Patients with LS values ≥7.0 kPa had a greater risk (hazard ratio, 9.472; 95% confidence interval, 1.018 to 88.126; p=0.048) for LRE development compared to those with LS values < 7.0 kPa. Conclusions: The LS value at SVR is useful for predicting LRE development in CHC patients who achieve SVR after treatment with peg-IFN plus ribavirin. Thus, LRE surveillance strategies might be optimized according to the LS values at SVR, even with complete viral eradication.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalGut and liver
Volume10
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Elasticity Imaging Techniques
Chronic Hepatitis C
Liver
Ribavirin
Interferons
Hepatocellular Carcinoma
Fetal Proteins
Mortality

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{797b9816f3cd4b14ac7e57acee724d21,
title = "Predicting liver-related events using transient elastography in chronic hepatitis C patients with sustained virological response",
abstract = "Background/Aims: Few studies have investigated prognostic factors for the development of liver-related events (LREs) in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). Methods: We analyzed 190 patients with CHC who achieved SVR after treatment with pegylated interferon (peg-IFN) plus ribavirin. LREs were defined as any complications related to cirrhosis, hepatocellular carcinoma (HCC), or liver-related mortality. Results: The mean age was 54.1 years, and 84 of the patients (44.2{\%}) were male. The mean liver stiffness (LS) value at SVR was 7.1±5.4 kPa. During the follow-up period (median, 43.0 months), LREs occurred in 10 patients (5.3{\%}; HCC in eight patients, ascites in one patient, and liver-related mortality in one patient). By multivariate Cox regression analysis, age, a-fetoprotein level, and LS value were independent predictors for LRE development (all p < 0.05). Patients with LS values ≥7.0 kPa had a greater risk (hazard ratio, 9.472; 95{\%} confidence interval, 1.018 to 88.126; p=0.048) for LRE development compared to those with LS values < 7.0 kPa. Conclusions: The LS value at SVR is useful for predicting LRE development in CHC patients who achieve SVR after treatment with peg-IFN plus ribavirin. Thus, LRE surveillance strategies might be optimized according to the LS values at SVR, even with complete viral eradication.",
author = "Lee, {Hye Won} and Chon, {Young Eun} and Kim, {Seung Up} and Kim, {Beom Kyung} and Park, {Jun Yong} and Kim, {Do Young} and Ahn, {Sang Hoon} and Jung, {Kyu Sik} and Park, {Young Nyun} and Han, {Kwang Hyub}",
year = "2016",
month = "1",
day = "1",
doi = "10.5009/gnl15021",
language = "English",
volume = "10",
pages = "429--436",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "3",

}

Predicting liver-related events using transient elastography in chronic hepatitis C patients with sustained virological response. / Lee, Hye Won; Chon, Young Eun; Kim, Seung Up; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Jung, Kyu Sik; Park, Young Nyun; Han, Kwang Hyub.

In: Gut and liver, Vol. 10, No. 3, 01.01.2016, p. 429-436.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predicting liver-related events using transient elastography in chronic hepatitis C patients with sustained virological response

AU - Lee, Hye Won

AU - Chon, Young Eun

AU - Kim, Seung Up

AU - Kim, Beom Kyung

AU - Park, Jun Yong

AU - Kim, Do Young

AU - Ahn, Sang Hoon

AU - Jung, Kyu Sik

AU - Park, Young Nyun

AU - Han, Kwang Hyub

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background/Aims: Few studies have investigated prognostic factors for the development of liver-related events (LREs) in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). Methods: We analyzed 190 patients with CHC who achieved SVR after treatment with pegylated interferon (peg-IFN) plus ribavirin. LREs were defined as any complications related to cirrhosis, hepatocellular carcinoma (HCC), or liver-related mortality. Results: The mean age was 54.1 years, and 84 of the patients (44.2%) were male. The mean liver stiffness (LS) value at SVR was 7.1±5.4 kPa. During the follow-up period (median, 43.0 months), LREs occurred in 10 patients (5.3%; HCC in eight patients, ascites in one patient, and liver-related mortality in one patient). By multivariate Cox regression analysis, age, a-fetoprotein level, and LS value were independent predictors for LRE development (all p < 0.05). Patients with LS values ≥7.0 kPa had a greater risk (hazard ratio, 9.472; 95% confidence interval, 1.018 to 88.126; p=0.048) for LRE development compared to those with LS values < 7.0 kPa. Conclusions: The LS value at SVR is useful for predicting LRE development in CHC patients who achieve SVR after treatment with peg-IFN plus ribavirin. Thus, LRE surveillance strategies might be optimized according to the LS values at SVR, even with complete viral eradication.

AB - Background/Aims: Few studies have investigated prognostic factors for the development of liver-related events (LREs) in patients with chronic hepatitis C (CHC) who achieve sustained virological response (SVR). Methods: We analyzed 190 patients with CHC who achieved SVR after treatment with pegylated interferon (peg-IFN) plus ribavirin. LREs were defined as any complications related to cirrhosis, hepatocellular carcinoma (HCC), or liver-related mortality. Results: The mean age was 54.1 years, and 84 of the patients (44.2%) were male. The mean liver stiffness (LS) value at SVR was 7.1±5.4 kPa. During the follow-up period (median, 43.0 months), LREs occurred in 10 patients (5.3%; HCC in eight patients, ascites in one patient, and liver-related mortality in one patient). By multivariate Cox regression analysis, age, a-fetoprotein level, and LS value were independent predictors for LRE development (all p < 0.05). Patients with LS values ≥7.0 kPa had a greater risk (hazard ratio, 9.472; 95% confidence interval, 1.018 to 88.126; p=0.048) for LRE development compared to those with LS values < 7.0 kPa. Conclusions: The LS value at SVR is useful for predicting LRE development in CHC patients who achieve SVR after treatment with peg-IFN plus ribavirin. Thus, LRE surveillance strategies might be optimized according to the LS values at SVR, even with complete viral eradication.

UR - http://www.scopus.com/inward/record.url?scp=84969166469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969166469&partnerID=8YFLogxK

U2 - 10.5009/gnl15021

DO - 10.5009/gnl15021

M3 - Article

C2 - 26347515

AN - SCOPUS:84969166469

VL - 10

SP - 429

EP - 436

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 3

ER -