Abstract
Background: Solid pseudopapillary tumors (SPTs) of the pancreas are still considered a surgical enigma. Many clinical research trials have failed to identify prognostic factors that predict the malignant behavior of SPTs. Materials and Methods: This work was a retrospective multicenter study that included a total of 17 medical institutions. Data from 351 patients who underwent surgical resection from January 1990 to December 2008 were retrospectively collected using standardized case report forms requesting clinicopathologic features. Results: Thirty-four patients (9.7%) were male, and 317 (90.3%) were female, with amean age of 36.8±12.4 years. Recently, minimally invasive (P<0.001) and parenchyma or function-preserving limited surgeries (P = 0.016) have been more frequently applied for the treatment of pancreatic SPTs. Ninetyeight patients (27.9%) had microscopic malignant features. Only 9 patients (2.6%) experienced tumor recurrence after the initial pancreatic SPT resection. Multivariate analysis showed that a tumor size larger than 8 cm [Exp (β) = 7.385, P = 0.018], microscopic malignant features [Exp (β) = 10.009, P = 0.011], and stage IV[Exp (β)=42.003, P=0.002]were significant prognostic factors for tumor recurrence. When combined with stage IV, the microscopic malignant features and 2010 World Health Organization definition of solid pseudopapillary carcinoma more successfully differentiated future recurrence risk groups (P < 0.001). Conclusions: More specific pathologic descriptions need to be employed in pathologic report forms to provide proper information to predict SPT recurrence after resection. Future studies emphasizing the standardized pathologic evaluation of pancreatic SPTs may unveil the enigmatic nature of pancreatic SPTs.
| Original language | English |
|---|---|
| Pages (from-to) | 348-355 |
| Number of pages | 8 |
| Journal | Annals of surgery |
| Volume | 260 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2014 Aug |
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All Science Journal Classification (ASJC) codes
- Surgery
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Predicting recurrence of pancreatic solid pseudopapillary tumors after surgical resection : A multicenter analysis in Korea. / Kang, Chang Moo; Choi, Sung Hoon; Kim, Song Cheol; Lee, Woo Jung; Choi, Dong Wook; Kim, Sun Whe.
In: Annals of surgery, Vol. 260, No. 2, 08.2014, p. 348-355.Research output: Contribution to journal › Article
TY - JOUR
T1 - Predicting recurrence of pancreatic solid pseudopapillary tumors after surgical resection
T2 - A multicenter analysis in Korea
AU - Kang, Chang Moo
AU - Choi, Sung Hoon
AU - Kim, Song Cheol
AU - Lee, Woo Jung
AU - Choi, Dong Wook
AU - Kim, Sun Whe
PY - 2014/8
Y1 - 2014/8
N2 - Background: Solid pseudopapillary tumors (SPTs) of the pancreas are still considered a surgical enigma. Many clinical research trials have failed to identify prognostic factors that predict the malignant behavior of SPTs. Materials and Methods: This work was a retrospective multicenter study that included a total of 17 medical institutions. Data from 351 patients who underwent surgical resection from January 1990 to December 2008 were retrospectively collected using standardized case report forms requesting clinicopathologic features. Results: Thirty-four patients (9.7%) were male, and 317 (90.3%) were female, with amean age of 36.8±12.4 years. Recently, minimally invasive (P<0.001) and parenchyma or function-preserving limited surgeries (P = 0.016) have been more frequently applied for the treatment of pancreatic SPTs. Ninetyeight patients (27.9%) had microscopic malignant features. Only 9 patients (2.6%) experienced tumor recurrence after the initial pancreatic SPT resection. Multivariate analysis showed that a tumor size larger than 8 cm [Exp (β) = 7.385, P = 0.018], microscopic malignant features [Exp (β) = 10.009, P = 0.011], and stage IV[Exp (β)=42.003, P=0.002]were significant prognostic factors for tumor recurrence. When combined with stage IV, the microscopic malignant features and 2010 World Health Organization definition of solid pseudopapillary carcinoma more successfully differentiated future recurrence risk groups (P < 0.001). Conclusions: More specific pathologic descriptions need to be employed in pathologic report forms to provide proper information to predict SPT recurrence after resection. Future studies emphasizing the standardized pathologic evaluation of pancreatic SPTs may unveil the enigmatic nature of pancreatic SPTs.
AB - Background: Solid pseudopapillary tumors (SPTs) of the pancreas are still considered a surgical enigma. Many clinical research trials have failed to identify prognostic factors that predict the malignant behavior of SPTs. Materials and Methods: This work was a retrospective multicenter study that included a total of 17 medical institutions. Data from 351 patients who underwent surgical resection from January 1990 to December 2008 were retrospectively collected using standardized case report forms requesting clinicopathologic features. Results: Thirty-four patients (9.7%) were male, and 317 (90.3%) were female, with amean age of 36.8±12.4 years. Recently, minimally invasive (P<0.001) and parenchyma or function-preserving limited surgeries (P = 0.016) have been more frequently applied for the treatment of pancreatic SPTs. Ninetyeight patients (27.9%) had microscopic malignant features. Only 9 patients (2.6%) experienced tumor recurrence after the initial pancreatic SPT resection. Multivariate analysis showed that a tumor size larger than 8 cm [Exp (β) = 7.385, P = 0.018], microscopic malignant features [Exp (β) = 10.009, P = 0.011], and stage IV[Exp (β)=42.003, P=0.002]were significant prognostic factors for tumor recurrence. When combined with stage IV, the microscopic malignant features and 2010 World Health Organization definition of solid pseudopapillary carcinoma more successfully differentiated future recurrence risk groups (P < 0.001). Conclusions: More specific pathologic descriptions need to be employed in pathologic report forms to provide proper information to predict SPT recurrence after resection. Future studies emphasizing the standardized pathologic evaluation of pancreatic SPTs may unveil the enigmatic nature of pancreatic SPTs.
UR - http://www.scopus.com/inward/record.url?scp=84905595421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905595421&partnerID=8YFLogxK
U2 - 10.1097/SLA.0000000000000583
DO - 10.1097/SLA.0000000000000583
M3 - Article
C2 - 24743622
AN - SCOPUS:84905595421
VL - 260
SP - 348
EP - 355
JO - Annals of Surgery
JF - Annals of Surgery
SN - 0003-4932
IS - 2
ER -