Predicting survival using the 2016 World Health Organization classification for anaplastic glioma

Je Beom Hong, Tae Hoon Roh, Sung Soo Ahn, Jung Youn Kim, Seok Gu Kang, Jong Hee Chang, Se Hoon Kim

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1 Citation (Scopus)

Abstract

Aim: This study aimed to investigate the survival and prognostic factors for anaplastic glioma, and whether the updated 2016 WHO classification had superior ability to predict survival. Materials and methods: Between January 2001 and December 2013, 113 consecutive patients were diagnosed with anaplastic glioma based on the 2007 WHO classification. We re-classified their diagnoses in accordance with the 2016 WHO classification. The Kaplan-Meier method, multivariate Cox proportional regression analysis, and a time-dependent receiver operating characteristic curve were used for the analysis. Results: The median overall survival was 48.4 months among all patients, and 21.5 months for the anaplastic astrocytoma, IDH wild-type (AAw) group. The median progression-free survival was 31.8 months among all patients and 16.4 in the AAw group. Age, MGMT promoter methylation status, deep tumor location, and resection extent were associated with overall survival and progression-free survival. Conclusion: We found that the 2016 WHO classification of central nervous system tumors had superior ability to predict survival in cases of anaplastic glioma, as compared to the 2007 WHO classification.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalClinical Neuropathology
Volume39
Issue number4
DOIs
Publication statusPublished - 2020 Aug

Bibliographical note

Funding Information:
This work was supported by the Brain Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (Grant No. 2016M3C7A1913844).

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology

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