Prediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment

Jin San Lee, Seong Kyung Cho, Hee Jin Kim, Yeo Jin Kim, Key Chung Park, Samuel N. Lockhart, Duk L. Na, Changsoo Kim, Sang Won Seo

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4 Citations (Scopus)

Abstract

To evaluate prediction models of cognitive trajectories in patients with nonamnestic mild cognitive impairment (naMCI) using group-based trajectory analysis, we evaluated 121 patients with naMCI who underwent at least their first three yearly assessments. Group-based trajectory models were used to classify cognitive trajectories based on Clinical Dementia Rating Sum of Boxes scores over four years in patients with naMCI. A total of 22 patients (18.2%) were classified into the "fast-decliners" group, while 99 patients (81.8%) were classified into the "slow-decliners" group. The mean age was higher in the fast-decliners than in the slow-decliners (p = 0.037). Compared to the slow-decliners, the fast-decliners were more frequently impaired in the domains of language (p = 0.038) and frontal/executive functions (p = 0.042), and had more frequent multiple-domain cognitive impairment (p = 0.006) on baseline neuropsychological tests. The rate of conversion to dementia was significantly higher in the fast-decliners than in the slow-decliners (86.4% vs. 10.1%, p < 0.001). Our findings showed that there are indeed distinct patterns of cognitive trajectories in patients with naMCI. Close observation of naMCI patients' baseline demographic and clinical profiles in clinical settings may help identify individuals at greatest risk for dementia.

Original languageEnglish
Article number10468
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

All Science Journal Classification (ASJC) codes

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    Lee, J. S., Cho, S. K., Kim, H. J., Kim, Y. J., Park, K. C., Lockhart, S. N., Na, D. L., Kim, C., & Seo, S. W. (2018). Prediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment. Scientific reports, 8(1), [10468]. https://doi.org/10.1038/s41598-018-28881-1