Prediction of adrenal adenomas with hypercortisolism by using adrenal computed tomography: Emphasis on contralateral adrenal thinning

Sung Yoon Park, Young Taik Oh, Dae Chul Jung, Yumie Rhee

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Purpose: To analyze computed tomography (CT) characteristics of adrenal adenomas with hypercortisolism on adrenal CT compared to adenomas with hyperaldosteronism. Materials and Methods: Thirty-two adrenal adenomas, consisting of group A (hypercortisolism, n = 16) and group B (hyperaldosteronism, n = 16), were evaluated with adrenal CT. Thirty-four patients without adrenal nodule on CT and hormonal abnormality (group C) were selected for comparison. In adenomas, lesion size, attenuation value, and absolute and relative washout were compared between groups A and B. The mean adrenal thickness was compared quantitatively and qualitatively between groups. Results: All of adenomas satisfied absolute (≥60%) or relative (≥40%) washout criteria of adrenal CT. The mean adrenal thickness was 1.6 ± 0.3 mm in group A, 2.9 ± 0.5 mm in group B, and 3.0 ± 0.4 mm in group C (group Aversus B or C, P < 0.001; group B versus C, P = 0.775). For differentiating group A from B, the area under the curve of quantitative and qualitative analyses for contralateral adrenal thickness was 0.982 and 0.934, respectively. Both sensitivity and specificity with cutoff of 2.0 mm or less in thickness and probably thin or more in visual score were 93.7% and 93.7%, and 87.5% and 93.7%, respectively, for predicting group A. Conclusions: Contralateral adrenal thinning on CT helps predict adrenal adenomas with hypercortisolism.

Original languageEnglish
Pages (from-to)741-746
Number of pages6
JournalJournal of Computer Assisted Tomography
Issue number5
Publication statusPublished - 2015 Sep 1


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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