Prediction of hypothyroidism after hemithyroidectomy: A biochemical and pathological analysis

Yoon Woo Koh, Seung Won Lee, Eun Chang Choi, Jong Dae Lee, Ji Oh Mok, Hee Kyung Kim, Eun Seok Koh, Jae Yong Lee, Shi Chan Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The possibility of postsurgical hypothyroidism after hemithyroidectomy is no longer a new subject. Although many previous studies have mentioned posthemithyroidectomy hypothyroidism, the incidence and contributing factors for hypothyroidism remain uncertain. We intended to evaluate the incidence and the time of development of hypothyroidism after hemithyroidectomy and to analyze the relationship of posthemithyroidectomy hypothyroidism with preoperative biochemical parameters and postoperative histopathological findings. From February 2001 through December 2004, 287 consecutive cases of hemithyroidectomized patients were retrospectively analyzed; 136 of these patients were included in this study after the exclusion criteria were applied. The relationship between posthemithyroidectomy hypothyroidism and several parameters such as sex, age, preoperative free T4, TSH, microsomal antibody (Ab), thyroglobulin antibody (Ab) levels and lymphocytic infiltration of the resected gland was statistically analyzed. Postoperative hypothyroidism developed in 58 patients (42.6%). In hypothyroid group, 11 patients (19%) showed overt hypothyroidism and 47 patients (81%) showed subclinical hypothyroidism. Preoperative TSH value was significantly higher in the hypothyroid group (2.15 ± 1.30 μU/ml) compared to the euthyroid group (1.29 ± 0.9 μU/ml). Positive ratio of preoperative microsomal Ab and thyroglobulin Ab were significantly higher in hypothyroid group (38.9 and 41.9%) compared to euthyroid group (3.6 and 19.3%) (P <0.05). In addition, patients with a higher grade of lymphocytic infiltration were found to have a higher probability of developing hypothyroidism. About 85% of postoperative hypothyroidism was detected between 1 and 6 months postoperatively. We might predict the possibility of developing the posthemithyroidectomy hypothyroidism especially in case of preoperatively positive microsomal antibody, thyroglobulin antibody and high-grade lymphocytic infiltration of the resected gland. In addition, our findings support the recommendation for regular serum TSH follow-up at least for 12 months after hemithyroidectomy.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume265
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

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Hypothyroidism
Antibodies
Thyroglobulin
Incidence

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Koh, Yoon Woo ; Lee, Seung Won ; Choi, Eun Chang ; Lee, Jong Dae ; Mok, Ji Oh ; Kim, Hee Kyung ; Koh, Eun Seok ; Lee, Jae Yong ; Kim, Shi Chan. / Prediction of hypothyroidism after hemithyroidectomy : A biochemical and pathological analysis. In: European Archives of Oto-Rhino-Laryngology. 2008 ; Vol. 265, No. 4. pp. 453-457.
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abstract = "The possibility of postsurgical hypothyroidism after hemithyroidectomy is no longer a new subject. Although many previous studies have mentioned posthemithyroidectomy hypothyroidism, the incidence and contributing factors for hypothyroidism remain uncertain. We intended to evaluate the incidence and the time of development of hypothyroidism after hemithyroidectomy and to analyze the relationship of posthemithyroidectomy hypothyroidism with preoperative biochemical parameters and postoperative histopathological findings. From February 2001 through December 2004, 287 consecutive cases of hemithyroidectomized patients were retrospectively analyzed; 136 of these patients were included in this study after the exclusion criteria were applied. The relationship between posthemithyroidectomy hypothyroidism and several parameters such as sex, age, preoperative free T4, TSH, microsomal antibody (Ab), thyroglobulin antibody (Ab) levels and lymphocytic infiltration of the resected gland was statistically analyzed. Postoperative hypothyroidism developed in 58 patients (42.6{\%}). In hypothyroid group, 11 patients (19{\%}) showed overt hypothyroidism and 47 patients (81{\%}) showed subclinical hypothyroidism. Preoperative TSH value was significantly higher in the hypothyroid group (2.15 ± 1.30 μU/ml) compared to the euthyroid group (1.29 ± 0.9 μU/ml). Positive ratio of preoperative microsomal Ab and thyroglobulin Ab were significantly higher in hypothyroid group (38.9 and 41.9{\%}) compared to euthyroid group (3.6 and 19.3{\%}) (P <0.05). In addition, patients with a higher grade of lymphocytic infiltration were found to have a higher probability of developing hypothyroidism. About 85{\%} of postoperative hypothyroidism was detected between 1 and 6 months postoperatively. We might predict the possibility of developing the posthemithyroidectomy hypothyroidism especially in case of preoperatively positive microsomal antibody, thyroglobulin antibody and high-grade lymphocytic infiltration of the resected gland. In addition, our findings support the recommendation for regular serum TSH follow-up at least for 12 months after hemithyroidectomy.",
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Prediction of hypothyroidism after hemithyroidectomy : A biochemical and pathological analysis. / Koh, Yoon Woo; Lee, Seung Won; Choi, Eun Chang; Lee, Jong Dae; Mok, Ji Oh; Kim, Hee Kyung; Koh, Eun Seok; Lee, Jae Yong; Kim, Shi Chan.

In: European Archives of Oto-Rhino-Laryngology, Vol. 265, No. 4, 01.04.2008, p. 453-457.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prediction of hypothyroidism after hemithyroidectomy

T2 - A biochemical and pathological analysis

AU - Koh, Yoon Woo

AU - Lee, Seung Won

AU - Choi, Eun Chang

AU - Lee, Jong Dae

AU - Mok, Ji Oh

AU - Kim, Hee Kyung

AU - Koh, Eun Seok

AU - Lee, Jae Yong

AU - Kim, Shi Chan

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AB - The possibility of postsurgical hypothyroidism after hemithyroidectomy is no longer a new subject. Although many previous studies have mentioned posthemithyroidectomy hypothyroidism, the incidence and contributing factors for hypothyroidism remain uncertain. We intended to evaluate the incidence and the time of development of hypothyroidism after hemithyroidectomy and to analyze the relationship of posthemithyroidectomy hypothyroidism with preoperative biochemical parameters and postoperative histopathological findings. From February 2001 through December 2004, 287 consecutive cases of hemithyroidectomized patients were retrospectively analyzed; 136 of these patients were included in this study after the exclusion criteria were applied. The relationship between posthemithyroidectomy hypothyroidism and several parameters such as sex, age, preoperative free T4, TSH, microsomal antibody (Ab), thyroglobulin antibody (Ab) levels and lymphocytic infiltration of the resected gland was statistically analyzed. Postoperative hypothyroidism developed in 58 patients (42.6%). In hypothyroid group, 11 patients (19%) showed overt hypothyroidism and 47 patients (81%) showed subclinical hypothyroidism. Preoperative TSH value was significantly higher in the hypothyroid group (2.15 ± 1.30 μU/ml) compared to the euthyroid group (1.29 ± 0.9 μU/ml). Positive ratio of preoperative microsomal Ab and thyroglobulin Ab were significantly higher in hypothyroid group (38.9 and 41.9%) compared to euthyroid group (3.6 and 19.3%) (P <0.05). In addition, patients with a higher grade of lymphocytic infiltration were found to have a higher probability of developing hypothyroidism. About 85% of postoperative hypothyroidism was detected between 1 and 6 months postoperatively. We might predict the possibility of developing the posthemithyroidectomy hypothyroidism especially in case of preoperatively positive microsomal antibody, thyroglobulin antibody and high-grade lymphocytic infiltration of the resected gland. In addition, our findings support the recommendation for regular serum TSH follow-up at least for 12 months after hemithyroidectomy.

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