Prediction of left atrial fibrosis with speckle tracking echocardiography in mitral valve disease

A comparative study with histopathology

Ae Young Her, Eui Young Choi, ChiYoung Shim, Byoung Wook Song, Sak Lee, Jong Won Ha, Se Joong Rim, Ki Chul Hwang, Byung Chul Chang, Namsik Chung

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background and Objectives: Left atrial (LA) fibrosis is a main determinant of LA remodeling and development of atrial fibrillation. However, non-invasive prediction of LA fibrosis is challenging. We investigated whether preoperative LA strain as measured by speckle tracking echocardiography could predict the degree of LA fibrosis and LA reverse remodeling after mitral valve (MV) surgery. Subjects and Methods: Speckle tracking echocardiography and LA volume measurements were performed in 50 patients one day before MV surgery. LA tissues were obtained during the surgery, and the degrees of their interstitial fibroses were measured. LA volume measurements were repeated within 30 days after surgery (n=50) and 1-year later (n=39). Results: Left atrial global strain was significantly correlated with the degree of LA fibrosis (r=-0.55, p<0.001), and its correlation was independent of age, underlying rhythm, presence of rheumatic heart disease and type of predominant MV disease (B=-1.37, 95% confidence interval -2.32 - -0.41, p=0.006). The degree of LA fibrosis was significantly correlated with early (r=-0.337, p=0.017) and 1-year (r=-0.477, p=0.002) percent LA volume reduction after MV surgery, but LA global strain was not significant. Conclusion: Left atrial strain as measured by speckle tracking echocardiography might be helpful for predicting the degree of LA fibrosis in patients with MV disease.

Original languageEnglish
Pages (from-to)311-318
Number of pages8
JournalKorean Circulation Journal
Volume42
Issue number5
DOIs
Publication statusPublished - 2012 May 1

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Mitral Valve
Echocardiography
Fibrosis
Atrial Remodeling
Rheumatic Heart Disease
Ambulatory Surgical Procedures
Atrial Fibrillation
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Her, Ae Young ; Choi, Eui Young ; Shim, ChiYoung ; Song, Byoung Wook ; Lee, Sak ; Ha, Jong Won ; Rim, Se Joong ; Hwang, Ki Chul ; Chang, Byung Chul ; Chung, Namsik. / Prediction of left atrial fibrosis with speckle tracking echocardiography in mitral valve disease : A comparative study with histopathology. In: Korean Circulation Journal. 2012 ; Vol. 42, No. 5. pp. 311-318.
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Prediction of left atrial fibrosis with speckle tracking echocardiography in mitral valve disease : A comparative study with histopathology. / Her, Ae Young; Choi, Eui Young; Shim, ChiYoung; Song, Byoung Wook; Lee, Sak; Ha, Jong Won; Rim, Se Joong; Hwang, Ki Chul; Chang, Byung Chul; Chung, Namsik.

In: Korean Circulation Journal, Vol. 42, No. 5, 01.05.2012, p. 311-318.

Research output: Contribution to journalArticle

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AU - Her, Ae Young

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AU - Song, Byoung Wook

AU - Lee, Sak

AU - Ha, Jong Won

AU - Rim, Se Joong

AU - Hwang, Ki Chul

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N2 - Background and Objectives: Left atrial (LA) fibrosis is a main determinant of LA remodeling and development of atrial fibrillation. However, non-invasive prediction of LA fibrosis is challenging. We investigated whether preoperative LA strain as measured by speckle tracking echocardiography could predict the degree of LA fibrosis and LA reverse remodeling after mitral valve (MV) surgery. Subjects and Methods: Speckle tracking echocardiography and LA volume measurements were performed in 50 patients one day before MV surgery. LA tissues were obtained during the surgery, and the degrees of their interstitial fibroses were measured. LA volume measurements were repeated within 30 days after surgery (n=50) and 1-year later (n=39). Results: Left atrial global strain was significantly correlated with the degree of LA fibrosis (r=-0.55, p<0.001), and its correlation was independent of age, underlying rhythm, presence of rheumatic heart disease and type of predominant MV disease (B=-1.37, 95% confidence interval -2.32 - -0.41, p=0.006). The degree of LA fibrosis was significantly correlated with early (r=-0.337, p=0.017) and 1-year (r=-0.477, p=0.002) percent LA volume reduction after MV surgery, but LA global strain was not significant. Conclusion: Left atrial strain as measured by speckle tracking echocardiography might be helpful for predicting the degree of LA fibrosis in patients with MV disease.

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