Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis

Seungup Kim, Ji Hoon Lee, doyoung kim, SangHoon Ahn, Kyu Sik Jung, Eun Hee Choi, Young Nyun Park, KwangHyub Han, Chae Yoon Chon, Junyong Park

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) can assess liver fibrosis noninvasively. This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis. Methods: Between March 2006 and April 2010, 128 CHB patients with who underwent LSM and liver biopsy (LB) before starting nucleot(s)ide analogues and showed histologically advanced fibrosis (≥F3) with a high viral loads [HBV DNA ≥2,000 IU/mL] were enrolled. All patients were followed regularly to detect LRE development, including hepatic decompensation (variceal bleeding, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome) and hepatocellular carcinoma (HCC). Results: The mean age of the patient (72 men, 56 women) was 52.2 years. During the median follow-up period [median 27.8 (12.6-61.6) months], LREs developed in 19 (14.8%) patients (five with hepatic decompensation, 13 with HCC, one with both). Together with age, multivariate analysis identified LSM as an independent predictor of LRE development [P<0.044; hazard ratio (HR), 1.038; 95% confidence interval (CI), 1.002-1.081]. When the study population was stratified into two groups using the optimal cutoff value (19 kPa), which maximized the sum of sensitivity (61.1%) and specificity (86.2%) from a time-dependent receiver operating characteristic curve, patients with LSM>19 kPa were at significantly greater risk than those with LSM≤19 kPa for LRE development (HR, 7.176; 95% CI, 2.257-22.812; P = 0.001). Conclusion: LSM can be a useful predictor of LRE development in CHB patients showing histologically advanced liver fibrosis.

Original languageEnglish
Article numbere36676
JournalPloS one
Volume7
Issue number5
DOIs
Publication statusPublished - 2012 May 4

Fingerprint

chronic hepatitis B
liver cirrhosis
Chronic Hepatitis B
Liver Cirrhosis
Liver
liver
prediction
Stiffness
hepatoma
Hepatocellular Carcinoma
Hepatorenal Syndrome
Elasticity Imaging Techniques
Hepatic Encephalopathy
encephalopathy
peritonitis
Biopsy
ascites
Peritonitis
Viral Load
Ascites

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{7c640edc962c4920a518b418dc2c7c15,
title = "Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis",
abstract = "Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan{\circledR}) can assess liver fibrosis noninvasively. This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis. Methods: Between March 2006 and April 2010, 128 CHB patients with who underwent LSM and liver biopsy (LB) before starting nucleot(s)ide analogues and showed histologically advanced fibrosis (≥F3) with a high viral loads [HBV DNA ≥2,000 IU/mL] were enrolled. All patients were followed regularly to detect LRE development, including hepatic decompensation (variceal bleeding, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome) and hepatocellular carcinoma (HCC). Results: The mean age of the patient (72 men, 56 women) was 52.2 years. During the median follow-up period [median 27.8 (12.6-61.6) months], LREs developed in 19 (14.8{\%}) patients (five with hepatic decompensation, 13 with HCC, one with both). Together with age, multivariate analysis identified LSM as an independent predictor of LRE development [P<0.044; hazard ratio (HR), 1.038; 95{\%} confidence interval (CI), 1.002-1.081]. When the study population was stratified into two groups using the optimal cutoff value (19 kPa), which maximized the sum of sensitivity (61.1{\%}) and specificity (86.2{\%}) from a time-dependent receiver operating characteristic curve, patients with LSM>19 kPa were at significantly greater risk than those with LSM≤19 kPa for LRE development (HR, 7.176; 95{\%} CI, 2.257-22.812; P = 0.001). Conclusion: LSM can be a useful predictor of LRE development in CHB patients showing histologically advanced liver fibrosis.",
author = "Seungup Kim and Lee, {Ji Hoon} and doyoung kim and SangHoon Ahn and Jung, {Kyu Sik} and Choi, {Eun Hee} and Park, {Young Nyun} and KwangHyub Han and Chon, {Chae Yoon} and Junyong Park",
year = "2012",
month = "5",
day = "4",
doi = "10.1371/journal.pone.0036676",
language = "English",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis. / Kim, Seungup; Lee, Ji Hoon; kim, doyoung; Ahn, SangHoon; Jung, Kyu Sik; Choi, Eun Hee; Park, Young Nyun; Han, KwangHyub; Chon, Chae Yoon; Park, Junyong.

In: PloS one, Vol. 7, No. 5, e36676, 04.05.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis

AU - Kim, Seungup

AU - Lee, Ji Hoon

AU - kim, doyoung

AU - Ahn, SangHoon

AU - Jung, Kyu Sik

AU - Choi, Eun Hee

AU - Park, Young Nyun

AU - Han, KwangHyub

AU - Chon, Chae Yoon

AU - Park, Junyong

PY - 2012/5/4

Y1 - 2012/5/4

N2 - Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) can assess liver fibrosis noninvasively. This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis. Methods: Between March 2006 and April 2010, 128 CHB patients with who underwent LSM and liver biopsy (LB) before starting nucleot(s)ide analogues and showed histologically advanced fibrosis (≥F3) with a high viral loads [HBV DNA ≥2,000 IU/mL] were enrolled. All patients were followed regularly to detect LRE development, including hepatic decompensation (variceal bleeding, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome) and hepatocellular carcinoma (HCC). Results: The mean age of the patient (72 men, 56 women) was 52.2 years. During the median follow-up period [median 27.8 (12.6-61.6) months], LREs developed in 19 (14.8%) patients (five with hepatic decompensation, 13 with HCC, one with both). Together with age, multivariate analysis identified LSM as an independent predictor of LRE development [P<0.044; hazard ratio (HR), 1.038; 95% confidence interval (CI), 1.002-1.081]. When the study population was stratified into two groups using the optimal cutoff value (19 kPa), which maximized the sum of sensitivity (61.1%) and specificity (86.2%) from a time-dependent receiver operating characteristic curve, patients with LSM>19 kPa were at significantly greater risk than those with LSM≤19 kPa for LRE development (HR, 7.176; 95% CI, 2.257-22.812; P = 0.001). Conclusion: LSM can be a useful predictor of LRE development in CHB patients showing histologically advanced liver fibrosis.

AB - Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) can assess liver fibrosis noninvasively. This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis. Methods: Between March 2006 and April 2010, 128 CHB patients with who underwent LSM and liver biopsy (LB) before starting nucleot(s)ide analogues and showed histologically advanced fibrosis (≥F3) with a high viral loads [HBV DNA ≥2,000 IU/mL] were enrolled. All patients were followed regularly to detect LRE development, including hepatic decompensation (variceal bleeding, ascites, hepatic encephalopathy, spontaneous bacterial peritonitis, hepatorenal syndrome) and hepatocellular carcinoma (HCC). Results: The mean age of the patient (72 men, 56 women) was 52.2 years. During the median follow-up period [median 27.8 (12.6-61.6) months], LREs developed in 19 (14.8%) patients (five with hepatic decompensation, 13 with HCC, one with both). Together with age, multivariate analysis identified LSM as an independent predictor of LRE development [P<0.044; hazard ratio (HR), 1.038; 95% confidence interval (CI), 1.002-1.081]. When the study population was stratified into two groups using the optimal cutoff value (19 kPa), which maximized the sum of sensitivity (61.1%) and specificity (86.2%) from a time-dependent receiver operating characteristic curve, patients with LSM>19 kPa were at significantly greater risk than those with LSM≤19 kPa for LRE development (HR, 7.176; 95% CI, 2.257-22.812; P = 0.001). Conclusion: LSM can be a useful predictor of LRE development in CHB patients showing histologically advanced liver fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=84860523129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860523129&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0036676

DO - 10.1371/journal.pone.0036676

M3 - Article

C2 - 22574212

AN - SCOPUS:84860523129

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e36676

ER -