Prediction of metachronous multiple primary cancers following the curative resection of gastric cancer

Chan Kim, Hong Jae Chon, Beodeul Kang, Kiyeol Kim, Hei Cheul Jeung, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Due to improved survival rate, gastric cancer (GC) patients have an increased risk of developing multiple primary cancer (MPC). The purpose of this study is to evaluate the clinicopathological features of MPC and to generate useful tools for the prediction of metachronous MPC following gastrectomy.Methods: 3066 patients who underwent curative resection of GC were reviewed retrospectively, based on the clinical information and the medical record.Results: The 5-year incidence of MPC was 2.5%. Of these, 54.3% had a metachronous MPC, while 45.7% had a synchronous MPC. The most prevalent site of metachronous MPC was the colorectum (26.3%), followed by lung (23.7%) and liver (18.4%). Multivariate logistic regression analysis revealed that old age at the time of GC diagnosis (≥60 years), early stage of GC (stage I and II), and multiplicity of GC at the time of gastrectomy were independent predictive factors for metachronous MPC. GC patients with either metachronous or synchronous MPC showed poorer survival than patients without MPC. In addition, patients with a metachronous MPC showed late survival disadvantage, while patients with a synchronous MPC showed early survival disadvantage. Furthermore, we were able to develop and internally validate a nomogram to predict the metachronous MPC after curative gastrectomy (C-index = 0.72).Conclusion: Patients at high risk of developing metachronous MPC after curative resection of GC were identified. Individual risk of developing metachronous MPC could be predicted by a novel nomogram. Further external validation with independent patient cohorts is required to improve the accuracy of prediction.

Original languageEnglish
Article number394
JournalBMC cancer
Volume13
DOIs
Publication statusPublished - 2013 Aug 23

All Science Journal Classification (ASJC) codes

  • Genetics
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Prediction of metachronous multiple primary cancers following the curative resection of gastric cancer'. Together they form a unique fingerprint.

  • Cite this