Prediction of microvascular invasion before curative resection of hepatocellular carcinoma

Kyung Kim Beom, Hyub Han Kwang, Nyun Park Young, Suk Park Mi, Sik Kim Kyung, Sub Choi Jin, Soo Moon Byung, Yoon Chon Chae, Myoung Moon Young, Hoon Ahn Sang

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background: The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated preoperative predictors of microvascular invasion. Methods: We reviewed 190 consecutive HCC patients given curative resection from 1999 to 2006. All were treatment-naive and monitored every 3 months after resection. Tumor recurrence, survivals, and clinicopathological factors associated with microvascular invasion were analyzed. Results: The 5-year disease-free survival (DFS) rate was 39.4%(median follow-up duration: 35 months). On resection pathology, 38.9% (74/190 patients) had microvascular invasion undetected preoperatively, using liver spiral computed tomography (CT) or angiography. Independent predictors of microvascular invasion were tumor size (P = 0.043), number (P = 0.011), and Edmondson grade (P = 0.001). Patients with Edmondson grade 1 and size <5 cm had no microvascular invasion, while those with grade ≥2 had higher incidences (7/18 patients, 38.8%) even in small tumor (<2 cm). When tumors recurred, presence of microvascular invasion independently increased incidences of multiple tumors, portal vein invasion, and diffuse-infiltrative patterns significantly. Conclusions: Preoperative predictors of microvascular invasion are tumor size, number, and Edmondson grade, which may be useful for making clinical decisions in both non-surgical and surgical candidates.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalJournal of surgical oncology
Volume97
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

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Hepatocellular Carcinoma
Neoplasms
Neoplasm Staging
Spiral Computed Tomography
Incidence
Portal Vein
Disease-Free Survival
Survival Rate
Pathology
Recurrence
Survival
Liver
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Beom, Kyung Kim ; Kwang, Hyub Han ; Young, Nyun Park ; Mi, Suk Park ; Kyung, Sik Kim ; Jin, Sub Choi ; Byung, Soo Moon ; Chae, Yoon Chon ; Young, Myoung Moon ; Sang, Hoon Ahn. / Prediction of microvascular invasion before curative resection of hepatocellular carcinoma. In: Journal of surgical oncology. 2008 ; Vol. 97, No. 3. pp. 246-252.
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abstract = "Background: The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated preoperative predictors of microvascular invasion. Methods: We reviewed 190 consecutive HCC patients given curative resection from 1999 to 2006. All were treatment-naive and monitored every 3 months after resection. Tumor recurrence, survivals, and clinicopathological factors associated with microvascular invasion were analyzed. Results: The 5-year disease-free survival (DFS) rate was 39.4{\%}(median follow-up duration: 35 months). On resection pathology, 38.9{\%} (74/190 patients) had microvascular invasion undetected preoperatively, using liver spiral computed tomography (CT) or angiography. Independent predictors of microvascular invasion were tumor size (P = 0.043), number (P = 0.011), and Edmondson grade (P = 0.001). Patients with Edmondson grade 1 and size <5 cm had no microvascular invasion, while those with grade ≥2 had higher incidences (7/18 patients, 38.8{\%}) even in small tumor (<2 cm). When tumors recurred, presence of microvascular invasion independently increased incidences of multiple tumors, portal vein invasion, and diffuse-infiltrative patterns significantly. Conclusions: Preoperative predictors of microvascular invasion are tumor size, number, and Edmondson grade, which may be useful for making clinical decisions in both non-surgical and surgical candidates.",
author = "Beom, {Kyung Kim} and Kwang, {Hyub Han} and Young, {Nyun Park} and Mi, {Suk Park} and Kyung, {Sik Kim} and Jin, {Sub Choi} and Byung, {Soo Moon} and Chae, {Yoon Chon} and Young, {Myoung Moon} and Sang, {Hoon Ahn}",
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Beom, KK, Kwang, HH, Young, NP, Mi, SP, Kyung, SK, Jin, SC, Byung, SM, Chae, YC, Young, MM & Sang, HA 2008, 'Prediction of microvascular invasion before curative resection of hepatocellular carcinoma', Journal of surgical oncology, vol. 97, no. 3, pp. 246-252. https://doi.org/10.1002/jso.20953

Prediction of microvascular invasion before curative resection of hepatocellular carcinoma. / Beom, Kyung Kim; Kwang, Hyub Han; Young, Nyun Park; Mi, Suk Park; Kyung, Sik Kim; Jin, Sub Choi; Byung, Soo Moon; Chae, Yoon Chon; Young, Myoung Moon; Sang, Hoon Ahn.

In: Journal of surgical oncology, Vol. 97, No. 3, 01.03.2008, p. 246-252.

Research output: Contribution to journalArticle

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T1 - Prediction of microvascular invasion before curative resection of hepatocellular carcinoma

AU - Beom, Kyung Kim

AU - Kwang, Hyub Han

AU - Young, Nyun Park

AU - Mi, Suk Park

AU - Kyung, Sik Kim

AU - Jin, Sub Choi

AU - Byung, Soo Moon

AU - Chae, Yoon Chon

AU - Young, Myoung Moon

AU - Sang, Hoon Ahn

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Background: The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated preoperative predictors of microvascular invasion. Methods: We reviewed 190 consecutive HCC patients given curative resection from 1999 to 2006. All were treatment-naive and monitored every 3 months after resection. Tumor recurrence, survivals, and clinicopathological factors associated with microvascular invasion were analyzed. Results: The 5-year disease-free survival (DFS) rate was 39.4%(median follow-up duration: 35 months). On resection pathology, 38.9% (74/190 patients) had microvascular invasion undetected preoperatively, using liver spiral computed tomography (CT) or angiography. Independent predictors of microvascular invasion were tumor size (P = 0.043), number (P = 0.011), and Edmondson grade (P = 0.001). Patients with Edmondson grade 1 and size <5 cm had no microvascular invasion, while those with grade ≥2 had higher incidences (7/18 patients, 38.8%) even in small tumor (<2 cm). When tumors recurred, presence of microvascular invasion independently increased incidences of multiple tumors, portal vein invasion, and diffuse-infiltrative patterns significantly. Conclusions: Preoperative predictors of microvascular invasion are tumor size, number, and Edmondson grade, which may be useful for making clinical decisions in both non-surgical and surgical candidates.

AB - Background: The accurate staging of hepatocellular carcinoma (HCC) is important in establishing treatment strategies and prognosis. Among tumor factors, microvascular invasion, one of TNM staging components and prognostic factors, is underestimated preoperatively, due to inaccuracy of imaging modalities. We investigated preoperative predictors of microvascular invasion. Methods: We reviewed 190 consecutive HCC patients given curative resection from 1999 to 2006. All were treatment-naive and monitored every 3 months after resection. Tumor recurrence, survivals, and clinicopathological factors associated with microvascular invasion were analyzed. Results: The 5-year disease-free survival (DFS) rate was 39.4%(median follow-up duration: 35 months). On resection pathology, 38.9% (74/190 patients) had microvascular invasion undetected preoperatively, using liver spiral computed tomography (CT) or angiography. Independent predictors of microvascular invasion were tumor size (P = 0.043), number (P = 0.011), and Edmondson grade (P = 0.001). Patients with Edmondson grade 1 and size <5 cm had no microvascular invasion, while those with grade ≥2 had higher incidences (7/18 patients, 38.8%) even in small tumor (<2 cm). When tumors recurred, presence of microvascular invasion independently increased incidences of multiple tumors, portal vein invasion, and diffuse-infiltrative patterns significantly. Conclusions: Preoperative predictors of microvascular invasion are tumor size, number, and Edmondson grade, which may be useful for making clinical decisions in both non-surgical and surgical candidates.

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