Prediction of postinfectious bronchiolitis obliterans prognosis in children

Jae Hwa Jung, Ga Eun Kim, In Kyung Min, Haerin Jang, Soo Yeon Kim, Min Jung Kim, Yoon Hee Kim, Hyun Joo Shin, Haesung Yoon, Myung Hyun Sohn, Mi Jung Lee, Kyung Won Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Introduction: The prognosis of postinfectious bronchiolitis obliterans (PIBO) has many implications, ranging between reduced quality of life and life-threatening complications. We evaluated the prognostic factors for PIBO using the baseline clinical characteristics of patients and built a prediction model for determining the prognoses of PIBO patients using the identified parameters. Methods: We included 47 PIBO patients who underwent spirometry and impulse oscillometry and followed them up for at least 1 year. A patient's prognosis was classified as poor if the patient experienced at least one of the following: persistent respiratory symptoms for more than 1 year, two or more instances of hospitalizations due to respiratory symptoms, or more than one intensive care unit admission. Results: The prognoses of 32/47 (68.1%) patients was good, while that of 15/47 (31.9%) was poor. Spirometry results showed significantly lower forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), forced expiratory flow at 25%–75% of FVC, and post-bronchodilator (BD) FEV1 values in the poor prognosis group; chest computed tomography (CT) demonstrated more inflammatory bronchiolitis findings. We created a nomogram for predicting prognoses using post-BD FEV1 and inflammatory bronchiolitis on chest CT. The area under the curve for the nomogram was 84.6% (95% confidence interval: 72.8%–96.4%). Conclusions: PIBO patients with lower pulmonary function values and more findings of inflammatory bronchiolitis on initial examination have poor prognoses. The nomogram for predicting PIBO prognosis is easy to use and can be applied at the time of diagnosis.

Original languageEnglish
Pages (from-to)1069-1076
Number of pages8
JournalPediatric Pulmonology
Issue number5
Publication statusPublished - 2021 May

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation Grant funded by the Korean Government (NRF‐2019R1F1A1058910).

Publisher Copyright:
© 2020 Wiley Periodicals LLC

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


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