Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan®) before curative resection of hepatocellular carcinoma: A pilot study

Seung Up Kim, Sang Hoon Ahn, Jun Yong Park, Do Young Kim, Chae Yoon Chon, Jin Sub Choi, Kyung Sik Kim, Kwang Hyub Han

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Abstract

Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) reflects the degree of hepatic fibrosis. This prospective study investigated how well LSM predicts the development of hepatic insufficiency after curative liver resection surgery for hepatocellular carcinoma. Methods: The study enrolled 72 consecutive patients who underwent a preoperative LSM to assess the degree of liver fibrosis followed by curative liver resection surgery for hepatocellular carcinoma between July 2006 and December 2007. The primary end point was the development of hepatic insufficiency. Results: The mean age of the patients was 54.9 years. Twenty patients (27.7%) had chronic hepatitis and 52 (72.3%) had cirrhosis (44 and 8 patients showed Child-Pugh class A and B, respectively). The mean LSM was 17.1 kPa. Twelve patients (16.6%) had segmentectomy only, 16 patients (22.2%) had bisegmentectomy, and 44 patients (61.2%) had lobectomy. Nine patients (12.5%) had stage I tumor, 56 (77.7%) had stage II, and 7 (9.8%) had stage III. Univariate and subsequent multivariate analyses revealed that preoperative LSM was the only independent risk factor for predicting the development of postoperative hepatic insufficiency (cutoff, 25.6 kPa; P = 0.001; relative risk, 19.14; 95% confidence interval, 2.71-135.36). Conclusions: LSM is potentially useful to predict the development of postoperative hepatic insufficiency in patients with hepatocellular carcinoma undergoing curative liver resection surgery.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalHepatology International
Volume2
Issue number4
DOIs
Publication statusPublished - 2008 Sep 8

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Hepatic Insufficiency
Hepatocellular Carcinoma
Liver
Fibrosis
Elasticity Imaging Techniques
Segmental Mastectomy
Chronic Hepatitis
Liver Cirrhosis
Multivariate Analysis
Prospective Studies
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

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title = "Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan{\circledR}) before curative resection of hepatocellular carcinoma: A pilot study",
abstract = "Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan{\circledR}) reflects the degree of hepatic fibrosis. This prospective study investigated how well LSM predicts the development of hepatic insufficiency after curative liver resection surgery for hepatocellular carcinoma. Methods: The study enrolled 72 consecutive patients who underwent a preoperative LSM to assess the degree of liver fibrosis followed by curative liver resection surgery for hepatocellular carcinoma between July 2006 and December 2007. The primary end point was the development of hepatic insufficiency. Results: The mean age of the patients was 54.9 years. Twenty patients (27.7{\%}) had chronic hepatitis and 52 (72.3{\%}) had cirrhosis (44 and 8 patients showed Child-Pugh class A and B, respectively). The mean LSM was 17.1 kPa. Twelve patients (16.6{\%}) had segmentectomy only, 16 patients (22.2{\%}) had bisegmentectomy, and 44 patients (61.2{\%}) had lobectomy. Nine patients (12.5{\%}) had stage I tumor, 56 (77.7{\%}) had stage II, and 7 (9.8{\%}) had stage III. Univariate and subsequent multivariate analyses revealed that preoperative LSM was the only independent risk factor for predicting the development of postoperative hepatic insufficiency (cutoff, 25.6 kPa; P = 0.001; relative risk, 19.14; 95{\%} confidence interval, 2.71-135.36). Conclusions: LSM is potentially useful to predict the development of postoperative hepatic insufficiency in patients with hepatocellular carcinoma undergoing curative liver resection surgery.",
author = "Kim, {Seung Up} and Ahn, {Sang Hoon} and Park, {Jun Yong} and Kim, {Do Young} and Chon, {Chae Yoon} and Choi, {Jin Sub} and Kim, {Kyung Sik} and Han, {Kwang Hyub}",
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T1 - Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan®) before curative resection of hepatocellular carcinoma

T2 - A pilot study

AU - Kim, Seung Up

AU - Ahn, Sang Hoon

AU - Park, Jun Yong

AU - Kim, Do Young

AU - Chon, Chae Yoon

AU - Choi, Jin Sub

AU - Kim, Kyung Sik

AU - Han, Kwang Hyub

PY - 2008/9/8

Y1 - 2008/9/8

N2 - Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) reflects the degree of hepatic fibrosis. This prospective study investigated how well LSM predicts the development of hepatic insufficiency after curative liver resection surgery for hepatocellular carcinoma. Methods: The study enrolled 72 consecutive patients who underwent a preoperative LSM to assess the degree of liver fibrosis followed by curative liver resection surgery for hepatocellular carcinoma between July 2006 and December 2007. The primary end point was the development of hepatic insufficiency. Results: The mean age of the patients was 54.9 years. Twenty patients (27.7%) had chronic hepatitis and 52 (72.3%) had cirrhosis (44 and 8 patients showed Child-Pugh class A and B, respectively). The mean LSM was 17.1 kPa. Twelve patients (16.6%) had segmentectomy only, 16 patients (22.2%) had bisegmentectomy, and 44 patients (61.2%) had lobectomy. Nine patients (12.5%) had stage I tumor, 56 (77.7%) had stage II, and 7 (9.8%) had stage III. Univariate and subsequent multivariate analyses revealed that preoperative LSM was the only independent risk factor for predicting the development of postoperative hepatic insufficiency (cutoff, 25.6 kPa; P = 0.001; relative risk, 19.14; 95% confidence interval, 2.71-135.36). Conclusions: LSM is potentially useful to predict the development of postoperative hepatic insufficiency in patients with hepatocellular carcinoma undergoing curative liver resection surgery.

AB - Background: Liver stiffness measurement (LSM) using transient elastography (FibroScan®) reflects the degree of hepatic fibrosis. This prospective study investigated how well LSM predicts the development of hepatic insufficiency after curative liver resection surgery for hepatocellular carcinoma. Methods: The study enrolled 72 consecutive patients who underwent a preoperative LSM to assess the degree of liver fibrosis followed by curative liver resection surgery for hepatocellular carcinoma between July 2006 and December 2007. The primary end point was the development of hepatic insufficiency. Results: The mean age of the patients was 54.9 years. Twenty patients (27.7%) had chronic hepatitis and 52 (72.3%) had cirrhosis (44 and 8 patients showed Child-Pugh class A and B, respectively). The mean LSM was 17.1 kPa. Twelve patients (16.6%) had segmentectomy only, 16 patients (22.2%) had bisegmentectomy, and 44 patients (61.2%) had lobectomy. Nine patients (12.5%) had stage I tumor, 56 (77.7%) had stage II, and 7 (9.8%) had stage III. Univariate and subsequent multivariate analyses revealed that preoperative LSM was the only independent risk factor for predicting the development of postoperative hepatic insufficiency (cutoff, 25.6 kPa; P = 0.001; relative risk, 19.14; 95% confidence interval, 2.71-135.36). Conclusions: LSM is potentially useful to predict the development of postoperative hepatic insufficiency in patients with hepatocellular carcinoma undergoing curative liver resection surgery.

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JF - Hepatology International

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