Prediction of recurrence of early gastric cancer after curative resection

Ji Fu Lai, Sungsoo Kim, Kiyeol Kim, Chen Li, Sung Jin Oh, WooJin Hyung, SunYoung Rha, Hyuncheol Chung, Seung Ho Choi, Lin Bo Wang, Sung Hoon Noh

Research output: Contribution to journalArticle

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Abstract

Background: Recurrence of early gastric cancer (EGC) after curative resection is rare, and the types of EGC that may recur have not been well studied. We attempted to create a system for predicting recurrence of EGC after R0 resection. Methods: From January 1987 to April 2005, 2,923 patients with EGC who underwent curative resection were retrospectively studied. Of them, 79 patients (2.7%) experienced recurrence. Logistic regression was performed to identify independent risk factors for overall recurrence and early recurrence (recurred within 24 months after resection) of EGC. A nomogram was developed on the basis of a Cox regression. Results: Median time to recurrence was 20.5 months, and early recurrence accounted for 60.7% of instances. Presence of lymph node metastasis and elevated gross type were independent risk factors for overall recurrence; patients with both identified risk factors had a higher recurrence rate than average level (17.5% vs. 2.7%, P < 0.001). Meanwhile, male gender, elevated gross type, and presence of lymph node metastasis were significantly associated with early recurrence, and in patients with all of the aforementioned identified risk factors, the early recurrence rate was higher (12.2% vs. 1.6%, P < 0.001). A nomogram for predicting the disease-free survival after operation was constructed. Its c-index was 0.79 and it appeared to be accurate. Conclusions: Recurrence of EGC after curative resection can be predicted by using common clinical characteristics. Patients at high risk of overall and early recurrence could be identified; individual disease-free survival was predictable by the internally validated nomogram.

Original languageEnglish
Pages (from-to)1896-1902
Number of pages7
JournalAnnals of Surgical Oncology
Volume16
Issue number7
DOIs
Publication statusPublished - 2009 Jul 1

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Stomach Neoplasms
Recurrence
Nomograms
Disease-Free Survival
Lymph Nodes
Neoplasm Metastasis
Logistic Models

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Lai, Ji Fu ; Kim, Sungsoo ; Kim, Kiyeol ; Li, Chen ; Oh, Sung Jin ; Hyung, WooJin ; Rha, SunYoung ; Chung, Hyuncheol ; Choi, Seung Ho ; Wang, Lin Bo ; Noh, Sung Hoon. / Prediction of recurrence of early gastric cancer after curative resection. In: Annals of Surgical Oncology. 2009 ; Vol. 16, No. 7. pp. 1896-1902.
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abstract = "Background: Recurrence of early gastric cancer (EGC) after curative resection is rare, and the types of EGC that may recur have not been well studied. We attempted to create a system for predicting recurrence of EGC after R0 resection. Methods: From January 1987 to April 2005, 2,923 patients with EGC who underwent curative resection were retrospectively studied. Of them, 79 patients (2.7{\%}) experienced recurrence. Logistic regression was performed to identify independent risk factors for overall recurrence and early recurrence (recurred within 24 months after resection) of EGC. A nomogram was developed on the basis of a Cox regression. Results: Median time to recurrence was 20.5 months, and early recurrence accounted for 60.7{\%} of instances. Presence of lymph node metastasis and elevated gross type were independent risk factors for overall recurrence; patients with both identified risk factors had a higher recurrence rate than average level (17.5{\%} vs. 2.7{\%}, P < 0.001). Meanwhile, male gender, elevated gross type, and presence of lymph node metastasis were significantly associated with early recurrence, and in patients with all of the aforementioned identified risk factors, the early recurrence rate was higher (12.2{\%} vs. 1.6{\%}, P < 0.001). A nomogram for predicting the disease-free survival after operation was constructed. Its c-index was 0.79 and it appeared to be accurate. Conclusions: Recurrence of EGC after curative resection can be predicted by using common clinical characteristics. Patients at high risk of overall and early recurrence could be identified; individual disease-free survival was predictable by the internally validated nomogram.",
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Prediction of recurrence of early gastric cancer after curative resection. / Lai, Ji Fu; Kim, Sungsoo; Kim, Kiyeol; Li, Chen; Oh, Sung Jin; Hyung, WooJin; Rha, SunYoung; Chung, Hyuncheol; Choi, Seung Ho; Wang, Lin Bo; Noh, Sung Hoon.

In: Annals of Surgical Oncology, Vol. 16, No. 7, 01.07.2009, p. 1896-1902.

Research output: Contribution to journalArticle

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T1 - Prediction of recurrence of early gastric cancer after curative resection

AU - Lai, Ji Fu

AU - Kim, Sungsoo

AU - Kim, Kiyeol

AU - Li, Chen

AU - Oh, Sung Jin

AU - Hyung, WooJin

AU - Rha, SunYoung

AU - Chung, Hyuncheol

AU - Choi, Seung Ho

AU - Wang, Lin Bo

AU - Noh, Sung Hoon

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N2 - Background: Recurrence of early gastric cancer (EGC) after curative resection is rare, and the types of EGC that may recur have not been well studied. We attempted to create a system for predicting recurrence of EGC after R0 resection. Methods: From January 1987 to April 2005, 2,923 patients with EGC who underwent curative resection were retrospectively studied. Of them, 79 patients (2.7%) experienced recurrence. Logistic regression was performed to identify independent risk factors for overall recurrence and early recurrence (recurred within 24 months after resection) of EGC. A nomogram was developed on the basis of a Cox regression. Results: Median time to recurrence was 20.5 months, and early recurrence accounted for 60.7% of instances. Presence of lymph node metastasis and elevated gross type were independent risk factors for overall recurrence; patients with both identified risk factors had a higher recurrence rate than average level (17.5% vs. 2.7%, P < 0.001). Meanwhile, male gender, elevated gross type, and presence of lymph node metastasis were significantly associated with early recurrence, and in patients with all of the aforementioned identified risk factors, the early recurrence rate was higher (12.2% vs. 1.6%, P < 0.001). A nomogram for predicting the disease-free survival after operation was constructed. Its c-index was 0.79 and it appeared to be accurate. Conclusions: Recurrence of EGC after curative resection can be predicted by using common clinical characteristics. Patients at high risk of overall and early recurrence could be identified; individual disease-free survival was predictable by the internally validated nomogram.

AB - Background: Recurrence of early gastric cancer (EGC) after curative resection is rare, and the types of EGC that may recur have not been well studied. We attempted to create a system for predicting recurrence of EGC after R0 resection. Methods: From January 1987 to April 2005, 2,923 patients with EGC who underwent curative resection were retrospectively studied. Of them, 79 patients (2.7%) experienced recurrence. Logistic regression was performed to identify independent risk factors for overall recurrence and early recurrence (recurred within 24 months after resection) of EGC. A nomogram was developed on the basis of a Cox regression. Results: Median time to recurrence was 20.5 months, and early recurrence accounted for 60.7% of instances. Presence of lymph node metastasis and elevated gross type were independent risk factors for overall recurrence; patients with both identified risk factors had a higher recurrence rate than average level (17.5% vs. 2.7%, P < 0.001). Meanwhile, male gender, elevated gross type, and presence of lymph node metastasis were significantly associated with early recurrence, and in patients with all of the aforementioned identified risk factors, the early recurrence rate was higher (12.2% vs. 1.6%, P < 0.001). A nomogram for predicting the disease-free survival after operation was constructed. Its c-index was 0.79 and it appeared to be accurate. Conclusions: Recurrence of EGC after curative resection can be predicted by using common clinical characteristics. Patients at high risk of overall and early recurrence could be identified; individual disease-free survival was predictable by the internally validated nomogram.

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U2 - 10.1245/s10434-009-0473-x

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