Prediction of Transmural Extent of Infarction with Contrast Echocardiographically Derived Index of Myocardial Blood Flow and Myocardial Blood Volume Fraction: Comparison with Contrast-enhanced Magnetic Resonance Imaging

Eui Young Choi, Hye Sun Seo, Sungha Park, Hyun Joo Kim, Jeong Ah Ahn, Young Guk Ko, Byoung Wook Choi, Seok Min Kang, Donghoon Choi, Jong Won Ha, Se Joong Rim, Yangsoo Jang, Namsik Chung

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Abstract

Background: We sought to determine the accuracy of myocardial contrast echocardiography (MCE)-derived index of myocardial blood flow and myocardial blood volume fraction (MBVF) in predicting transmural extent of infarction and wall-motion recovery. Methods: Low and high mechanical index MCE and contrast-enhanced magnetic resonance imaging were performed 5 to 7 days after successful percutaneous revascularization in 30 patients with acute myocardial infarction and regional wall-motion change was assessed 3 months later. The index of myocardial blood flow was calculated as A × β (dB/s) using the equation y = A (1 - e-βt), which fits the replenishment curve of low mechanical index MCE. The MBVF (mL/100 g myocardium) was calculated as 100 × 10relative contrast intensity [CI]/10, using the relative CI by subtracting the cavity CI from the adjacent transmural CI using high mechanical index MCE. The contrast-enhanced magnetic resonance imaging-derived transmural extent of delayed hyperenhancement (DE) in 16 segments were measured and compared with corresponding MCE data. Results: Among 480 segments, 382 measurable segments were subdivided into 5 groups as follows: no DE, 1% to 25% DE, 26% to 50% DE, 51% to 75% DE, and 76% to 100% DE. An increment of the extent of DE was significantly related to a decrement of A × β (P < .001) and MBVF (P < .001). The optimal cut-off MBVF for predicting greater than 50% DE was 1.92 mL (sensitivity 82%, specificity 73%, P < .01), and persistently dysfunctional motion was 1.81 mL (sensitivity 74%, specificity 75%, P < .01). Conclusion: The MCE-derived A × β and MBVF can be effective predictors of transmural extent of infarction and wall-motion recovery in the reperfused acute myocardial infarction.

Original languageEnglish
Pages (from-to)1211-1219
Number of pages9
JournalJournal of the American Society of Echocardiography
Volume19
Issue number10
DOIs
Publication statusPublished - 2006 Oct 1

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Blood Volume
Infarction
Echocardiography
Magnetic Resonance Imaging
Myocardial Infarction
Sensitivity and Specificity
Myocardium

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{9b520c50dea944f2b7d3242081308ff3,
title = "Prediction of Transmural Extent of Infarction with Contrast Echocardiographically Derived Index of Myocardial Blood Flow and Myocardial Blood Volume Fraction: Comparison with Contrast-enhanced Magnetic Resonance Imaging",
abstract = "Background: We sought to determine the accuracy of myocardial contrast echocardiography (MCE)-derived index of myocardial blood flow and myocardial blood volume fraction (MBVF) in predicting transmural extent of infarction and wall-motion recovery. Methods: Low and high mechanical index MCE and contrast-enhanced magnetic resonance imaging were performed 5 to 7 days after successful percutaneous revascularization in 30 patients with acute myocardial infarction and regional wall-motion change was assessed 3 months later. The index of myocardial blood flow was calculated as A × β (dB/s) using the equation y = A (1 - e-βt), which fits the replenishment curve of low mechanical index MCE. The MBVF (mL/100 g myocardium) was calculated as 100 × 10relative contrast intensity [CI]/10, using the relative CI by subtracting the cavity CI from the adjacent transmural CI using high mechanical index MCE. The contrast-enhanced magnetic resonance imaging-derived transmural extent of delayed hyperenhancement (DE) in 16 segments were measured and compared with corresponding MCE data. Results: Among 480 segments, 382 measurable segments were subdivided into 5 groups as follows: no DE, 1{\%} to 25{\%} DE, 26{\%} to 50{\%} DE, 51{\%} to 75{\%} DE, and 76{\%} to 100{\%} DE. An increment of the extent of DE was significantly related to a decrement of A × β (P < .001) and MBVF (P < .001). The optimal cut-off MBVF for predicting greater than 50{\%} DE was 1.92 mL (sensitivity 82{\%}, specificity 73{\%}, P < .01), and persistently dysfunctional motion was 1.81 mL (sensitivity 74{\%}, specificity 75{\%}, P < .01). Conclusion: The MCE-derived A × β and MBVF can be effective predictors of transmural extent of infarction and wall-motion recovery in the reperfused acute myocardial infarction.",
author = "Choi, {Eui Young} and Seo, {Hye Sun} and Sungha Park and Kim, {Hyun Joo} and Ahn, {Jeong Ah} and Ko, {Young Guk} and Choi, {Byoung Wook} and Kang, {Seok Min} and Donghoon Choi and Ha, {Jong Won} and Rim, {Se Joong} and Yangsoo Jang and Namsik Chung",
year = "2006",
month = "10",
day = "1",
doi = "10.1016/j.echo.2006.04.027",
language = "English",
volume = "19",
pages = "1211--1219",
journal = "Journal of the American Society of Echocardiography",
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Prediction of Transmural Extent of Infarction with Contrast Echocardiographically Derived Index of Myocardial Blood Flow and Myocardial Blood Volume Fraction : Comparison with Contrast-enhanced Magnetic Resonance Imaging. / Choi, Eui Young; Seo, Hye Sun; Park, Sungha; Kim, Hyun Joo; Ahn, Jeong Ah; Ko, Young Guk; Choi, Byoung Wook; Kang, Seok Min; Choi, Donghoon; Ha, Jong Won; Rim, Se Joong; Jang, Yangsoo; Chung, Namsik.

In: Journal of the American Society of Echocardiography, Vol. 19, No. 10, 01.10.2006, p. 1211-1219.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prediction of Transmural Extent of Infarction with Contrast Echocardiographically Derived Index of Myocardial Blood Flow and Myocardial Blood Volume Fraction

T2 - Comparison with Contrast-enhanced Magnetic Resonance Imaging

AU - Choi, Eui Young

AU - Seo, Hye Sun

AU - Park, Sungha

AU - Kim, Hyun Joo

AU - Ahn, Jeong Ah

AU - Ko, Young Guk

AU - Choi, Byoung Wook

AU - Kang, Seok Min

AU - Choi, Donghoon

AU - Ha, Jong Won

AU - Rim, Se Joong

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Background: We sought to determine the accuracy of myocardial contrast echocardiography (MCE)-derived index of myocardial blood flow and myocardial blood volume fraction (MBVF) in predicting transmural extent of infarction and wall-motion recovery. Methods: Low and high mechanical index MCE and contrast-enhanced magnetic resonance imaging were performed 5 to 7 days after successful percutaneous revascularization in 30 patients with acute myocardial infarction and regional wall-motion change was assessed 3 months later. The index of myocardial blood flow was calculated as A × β (dB/s) using the equation y = A (1 - e-βt), which fits the replenishment curve of low mechanical index MCE. The MBVF (mL/100 g myocardium) was calculated as 100 × 10relative contrast intensity [CI]/10, using the relative CI by subtracting the cavity CI from the adjacent transmural CI using high mechanical index MCE. The contrast-enhanced magnetic resonance imaging-derived transmural extent of delayed hyperenhancement (DE) in 16 segments were measured and compared with corresponding MCE data. Results: Among 480 segments, 382 measurable segments were subdivided into 5 groups as follows: no DE, 1% to 25% DE, 26% to 50% DE, 51% to 75% DE, and 76% to 100% DE. An increment of the extent of DE was significantly related to a decrement of A × β (P < .001) and MBVF (P < .001). The optimal cut-off MBVF for predicting greater than 50% DE was 1.92 mL (sensitivity 82%, specificity 73%, P < .01), and persistently dysfunctional motion was 1.81 mL (sensitivity 74%, specificity 75%, P < .01). Conclusion: The MCE-derived A × β and MBVF can be effective predictors of transmural extent of infarction and wall-motion recovery in the reperfused acute myocardial infarction.

AB - Background: We sought to determine the accuracy of myocardial contrast echocardiography (MCE)-derived index of myocardial blood flow and myocardial blood volume fraction (MBVF) in predicting transmural extent of infarction and wall-motion recovery. Methods: Low and high mechanical index MCE and contrast-enhanced magnetic resonance imaging were performed 5 to 7 days after successful percutaneous revascularization in 30 patients with acute myocardial infarction and regional wall-motion change was assessed 3 months later. The index of myocardial blood flow was calculated as A × β (dB/s) using the equation y = A (1 - e-βt), which fits the replenishment curve of low mechanical index MCE. The MBVF (mL/100 g myocardium) was calculated as 100 × 10relative contrast intensity [CI]/10, using the relative CI by subtracting the cavity CI from the adjacent transmural CI using high mechanical index MCE. The contrast-enhanced magnetic resonance imaging-derived transmural extent of delayed hyperenhancement (DE) in 16 segments were measured and compared with corresponding MCE data. Results: Among 480 segments, 382 measurable segments were subdivided into 5 groups as follows: no DE, 1% to 25% DE, 26% to 50% DE, 51% to 75% DE, and 76% to 100% DE. An increment of the extent of DE was significantly related to a decrement of A × β (P < .001) and MBVF (P < .001). The optimal cut-off MBVF for predicting greater than 50% DE was 1.92 mL (sensitivity 82%, specificity 73%, P < .01), and persistently dysfunctional motion was 1.81 mL (sensitivity 74%, specificity 75%, P < .01). Conclusion: The MCE-derived A × β and MBVF can be effective predictors of transmural extent of infarction and wall-motion recovery in the reperfused acute myocardial infarction.

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U2 - 10.1016/j.echo.2006.04.027

DO - 10.1016/j.echo.2006.04.027

M3 - Article

C2 - 17000359

AN - SCOPUS:33748806811

VL - 19

SP - 1211

EP - 1219

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 10

ER -