Abstract
Most guidelines suggest combination therapy including nucleoside and nucleotide analogues for the treatment of chronic hepatitis B (CHB) with multidrug resistance (MD-R). However, long-term combination treatment can evoke high costs and safety problems. Therefore, we investigated the efficacy of tenofovir disoproxil fumarate (TDF) mono-rescue therapy for viral suppression in patients with CHB exhibiting MD-R. We reviewed patients with CHB exhibiting antiviral drug resistance treated by TDF mono-rescue therapy from December 2012 to June 2014. The patients were categorized into three groups: lamivudine-resistance (LAM-R) group (n=290), and LAM-R+adefovir-resistance (ADV-R) group (n=43), and LAM-R+entecavir-resistance (ETV-R) group (n=113). We compared the virologic response rate according to the multiplicity of resistance and investigated the predictive factors of a virologic response. For a median of 15 months (range, 6-24 months) of TDF mono-rescue therapy, the cumulative virologic response rates were 82.8, 81.4, and 84.1% in the LAM-R, LAM-R+ADV-R, and LAM-R+ETV-R groups, respectively (P=0.239). Multivariate analysis revealed that multiplicity of resistance did not influence the achievement of a virologic response (P=0.218). However, the baseline HBV DNA level significantly influenced the achievement of a virologic response for the treatment of CHB with MD-R (P<0.001). TDF mono-rescue therapy is an appropriate treatment for CHB with MD-R, and the baseline HBV DNA level is a significant predictive factor for a virologic response. These factors should be considered before treating CHB with MD-R.
Original language | English |
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Pages (from-to) | 1027-1034 |
Number of pages | 8 |
Journal | Journal of Medical Virology |
Volume | 88 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2016 Jun 1 |
Bibliographical note
Publisher Copyright:© 2015 Wiley Periodicals, Inc.
All Science Journal Classification (ASJC) codes
- Virology
- Infectious Diseases