Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis

Hyung Seok Lee, Hye Sun Lee, Hyo Eun Lee, Mi Kyung Bae, Kyung Young Chung, Ha Young Shin, Youngchul Choi, Seung Min Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Predictive factors for myasthenic crisis after transsternal thymectomy have been reported, but little is known about myasthenic crisis after videoscopic thymectomy (MCAVT). Methods: We investigated 146 myasthenia gravis patients who underwent videoscopic thymectomy. Results: Patients with MCAVT had a lower forced vital capacity (FVC) (2.1 vs. 3.0 L, P<0.001) than those without. Low-frequency repetitive nerve stimulation showed decremental responses of the orbicularis oculi (47.1% vs. 18.1%, P=0.001) and nasalis muscles (54.1% vs. 21.4%, P<0.001), which were more pronounced in patients with MCAVT than those without. According to multivariate analysis, FVC (OR 0.144, 95% confidence interval [CI], 0.044-0.479, P=0.002) and decremental response of orbicularis oculi (odds ratio, 1.029; 95% CI, 1.001-1.058, P=0.044) were independently associated with MCAVT. Conclusions: FVC and decremental response of orbicularis oculi were associated with MCAVT.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalMuscle and Nerve
Volume52
Issue number2
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Thymectomy
Myasthenia Gravis
Muscle Weakness
Vital Capacity
Confidence Intervals
Multivariate Analysis
Odds Ratio
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Lee, H. S., Lee, H. S., Lee, H. E., Bae, M. K., Chung, K. Y., Shin, H. Y., ... Kim, S. M. (2015). Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis. Muscle and Nerve, 52(2), 216-220. https://doi.org/10.1002/mus.24531
Lee, Hyung Seok ; Lee, Hye Sun ; Lee, Hyo Eun ; Bae, Mi Kyung ; Chung, Kyung Young ; Shin, Ha Young ; Choi, Youngchul ; Kim, Seung Min. / Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis. In: Muscle and Nerve. 2015 ; Vol. 52, No. 2. pp. 216-220.
@article{dd8995b1824d42429c95cf143e95105d,
title = "Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis",
abstract = "Introduction: Predictive factors for myasthenic crisis after transsternal thymectomy have been reported, but little is known about myasthenic crisis after videoscopic thymectomy (MCAVT). Methods: We investigated 146 myasthenia gravis patients who underwent videoscopic thymectomy. Results: Patients with MCAVT had a lower forced vital capacity (FVC) (2.1 vs. 3.0 L, P<0.001) than those without. Low-frequency repetitive nerve stimulation showed decremental responses of the orbicularis oculi (47.1{\%} vs. 18.1{\%}, P=0.001) and nasalis muscles (54.1{\%} vs. 21.4{\%}, P<0.001), which were more pronounced in patients with MCAVT than those without. According to multivariate analysis, FVC (OR 0.144, 95{\%} confidence interval [CI], 0.044-0.479, P=0.002) and decremental response of orbicularis oculi (odds ratio, 1.029; 95{\%} CI, 1.001-1.058, P=0.044) were independently associated with MCAVT. Conclusions: FVC and decremental response of orbicularis oculi were associated with MCAVT.",
author = "Lee, {Hyung Seok} and Lee, {Hye Sun} and Lee, {Hyo Eun} and Bae, {Mi Kyung} and Chung, {Kyung Young} and Shin, {Ha Young} and Youngchul Choi and Kim, {Seung Min}",
year = "2015",
month = "1",
day = "1",
doi = "10.1002/mus.24531",
language = "English",
volume = "52",
pages = "216--220",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis. / Lee, Hyung Seok; Lee, Hye Sun; Lee, Hyo Eun; Bae, Mi Kyung; Chung, Kyung Young; Shin, Ha Young; Choi, Youngchul; Kim, Seung Min.

In: Muscle and Nerve, Vol. 52, No. 2, 01.01.2015, p. 216-220.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis

AU - Lee, Hyung Seok

AU - Lee, Hye Sun

AU - Lee, Hyo Eun

AU - Bae, Mi Kyung

AU - Chung, Kyung Young

AU - Shin, Ha Young

AU - Choi, Youngchul

AU - Kim, Seung Min

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Introduction: Predictive factors for myasthenic crisis after transsternal thymectomy have been reported, but little is known about myasthenic crisis after videoscopic thymectomy (MCAVT). Methods: We investigated 146 myasthenia gravis patients who underwent videoscopic thymectomy. Results: Patients with MCAVT had a lower forced vital capacity (FVC) (2.1 vs. 3.0 L, P<0.001) than those without. Low-frequency repetitive nerve stimulation showed decremental responses of the orbicularis oculi (47.1% vs. 18.1%, P=0.001) and nasalis muscles (54.1% vs. 21.4%, P<0.001), which were more pronounced in patients with MCAVT than those without. According to multivariate analysis, FVC (OR 0.144, 95% confidence interval [CI], 0.044-0.479, P=0.002) and decremental response of orbicularis oculi (odds ratio, 1.029; 95% CI, 1.001-1.058, P=0.044) were independently associated with MCAVT. Conclusions: FVC and decremental response of orbicularis oculi were associated with MCAVT.

AB - Introduction: Predictive factors for myasthenic crisis after transsternal thymectomy have been reported, but little is known about myasthenic crisis after videoscopic thymectomy (MCAVT). Methods: We investigated 146 myasthenia gravis patients who underwent videoscopic thymectomy. Results: Patients with MCAVT had a lower forced vital capacity (FVC) (2.1 vs. 3.0 L, P<0.001) than those without. Low-frequency repetitive nerve stimulation showed decremental responses of the orbicularis oculi (47.1% vs. 18.1%, P=0.001) and nasalis muscles (54.1% vs. 21.4%, P<0.001), which were more pronounced in patients with MCAVT than those without. According to multivariate analysis, FVC (OR 0.144, 95% confidence interval [CI], 0.044-0.479, P=0.002) and decremental response of orbicularis oculi (odds ratio, 1.029; 95% CI, 1.001-1.058, P=0.044) were independently associated with MCAVT. Conclusions: FVC and decremental response of orbicularis oculi were associated with MCAVT.

UR - http://www.scopus.com/inward/record.url?scp=84937526330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937526330&partnerID=8YFLogxK

U2 - 10.1002/mus.24531

DO - 10.1002/mus.24531

M3 - Article

C2 - 25470186

AN - SCOPUS:84937526330

VL - 52

SP - 216

EP - 220

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 2

ER -