Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis

Hyung Seok Lee, Hye Sun Lee, Hyo Eun Lee, Mi Kyung Bae, Kyung Young Chung, Ha Young Shin, Young Chul Choi, Seung Min Kim

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Abstract

Introduction: Predictive factors for myasthenic crisis after transsternal thymectomy have been reported, but little is known about myasthenic crisis after videoscopic thymectomy (MCAVT). Methods: We investigated 146 myasthenia gravis patients who underwent videoscopic thymectomy. Results: Patients with MCAVT had a lower forced vital capacity (FVC) (2.1 vs. 3.0 L, P<0.001) than those without. Low-frequency repetitive nerve stimulation showed decremental responses of the orbicularis oculi (47.1% vs. 18.1%, P=0.001) and nasalis muscles (54.1% vs. 21.4%, P<0.001), which were more pronounced in patients with MCAVT than those without. According to multivariate analysis, FVC (OR 0.144, 95% confidence interval [CI], 0.044-0.479, P=0.002) and decremental response of orbicularis oculi (odds ratio, 1.029; 95% CI, 1.001-1.058, P=0.044) were independently associated with MCAVT. Conclusions: FVC and decremental response of orbicularis oculi were associated with MCAVT.

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalMuscle and Nerve
Volume52
Issue number2
DOIs
Publication statusPublished - 2015 Aug 1

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Lee, H. S., Lee, H. S., Lee, H. E., Bae, M. K., Chung, K. Y., Shin, H. Y., Choi, Y. C., & Kim, S. M. (2015). Predictive factors for myasthenic crisis after videoscopic thymectomy in patients with myasthenia gravis. Muscle and Nerve, 52(2), 216-220. https://doi.org/10.1002/mus.24531